Results 41 to 50 of about 615,496 (172)
Mass spectrometry quantification of clusterin in the human brain
Molecular Neurodegeneration, 2012 Background The multifunctional glycoprotein clusterin has been associated with late-onset Alzheimer’s disease (AD). Further investigation to define the role of clusterin in AD phenotypes would be aided by the development of techniques to quantify level ...
Chen Junjun +2 more
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Novel biochemistry: post-translational protein splicing and other lessons from the school of antigen processing [PDF]
Journal of Molecular Medicine, 2005 In the past 15 years, the molecular identification of antigens that can mediate the killing of tumor cells by T cells has been vigorously pursued. Molecular identification of tumor-associated antigens not only provided the means to activate or monitor anti-tumor immunity, but also gave insights into new and unexpected biochemical processes that are ...
Hanada, Ken-Ichi, Yang, James C.
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Modifications and Trafficking of APP in the Pathogenesis of Alzheimer’s Disease
Frontiers in Molecular Neuroscience, 2017 Alzheimer’s disease (AD), the most common neurodegenerative disorder, is the leading cause of dementia. Neuritic plaque, one of the major characteristics of AD neuropathology, mainly consists of amyloid β (Aβ) protein.
Xin Wang +12 more
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Research progress of Nedd4L in cardiovascular diseases
Cell Death Discovery, 2022 Post-translational modifications (PTMs) are a covalent processing process of proteins after translation. Proteins are capable of playing their roles only after being modified, so as to maintain the normal physiological function of cells.
Mohan Li +8 more
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Dynamic network analysis improves protein 3D structural classification [PDF]
arXiv, 2021 Protein structural classification (PSC) is a supervised problem of assigning proteins into pre-defined structural (e.g., CATH or SCOPe) classes based on the proteins' sequence or 3D structural features. We recently proposed PSC approaches that model protein 3D structures as protein structure networks (PSNs) and analyze PSN-based protein features, which
arxiv
Artificial intelligence-aided protein engineering: from topological data analysis to deep protein language models [PDF]
arXiv, 2023 Protein engineering is an emerging field in biotechnology that has the potential to revolutionize various areas, such as antibody design, drug discovery, food security, ecology, and more. However, the mutational space involved is too vast to be handled through experimental means alone.
arxiv
Comprehensive analysis of human protein N-termini enables assessment of various protein forms
Scientific Reports, 2017 Various forms of protein (proteoforms) are generated by genetic variations, alternative splicing, alternative translation initiation, co- or post-translational modification and proteolysis.
Jeonghun Yeom +4 more
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Axioms, 2022 Post-translational glycosylation and glycation are common types of protein post-translational modifications (PTMs) in which glycan binds to protein enzymatically or nonenzymatically, respectively.
Alhasan Alkuhlani +4 more
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Journal of Biological Chemistry, 1993 SpYPT5p is a member of the rab/YPT small GTP-binding protein family, which is believed to be involved in the regulation of intracellular trafficking. The protein sequence terminates with a CXC motif, and in our previous report (Newman, C. M. H., Giannakouros, T., Hancock, J. F., Fawell, E. H., Armstrong, J., and Magee, A. I. (1992) J. Biol. Chem.
Anthony I. Magee +4 more
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PLoS ONE, 2009 BackgroundHfq is a bacterial protein involved in several aspects of nucleic acid transactions, but one of its best-characterized functions is to affect the post-transcriptional regulation of mRNA by virtue of its interactions with stress-related small ...
Elia Diestra +3 more
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