Results 41 to 50 of about 750,523 (310)
Cell Communication and Signaling, 2021 Controlling the activation of the NLRP3 inflammasome by post-translational modifications (PTMs) of critical protein subunits has emerged as a key determinant in inflammatory processes as well as in pathophysiology. In this review, we put into context the
Zhu Liang +3 more
doaj +1 more source
A mixed clustering coefficient centrality for identifying essential proteins [PDF]
, 2020 Essential protein plays a crucial role in the process of cell life. The identification of essential proteins can not only promote the development of drug target technology, but also contribute to the mechanism of biological evolution. There are plenty of scholars who pay attention to discovering essential proteins according to the topological structure
arxiv +1 more source
FMDV replicons encoding green fluorescent protein are replication competent [PDF]
, 2014 The study of replication of viruses that require high bio-secure facilities can be accomplished with less stringent containment using non-infectious 'replicon' systems. The FMDV replicon system (pT7rep) reported by Mclnerney et al. (2000) was modified by
Angus I. Lamond +28 more
core +4 more sources
Biogenesis of mitochondrial ubiquinol [PDF]
, 1982 The precursor proteins to the subunits of ubiquinol:cytochrome c reductase (cytochrome bc1 complex) of Neurospora crassa were synthesized in a reticulocyte lysate.
Neupert, Walter +3 more
core +1 more source
Predicting mutational effects on protein-protein binding via a side-chain diffusion probabilistic model [PDF]
arXiv, 2023 Many crucial biological processes rely on networks of protein-protein interactions. Predicting the effect of amino acid mutations on protein-protein binding is vital in protein engineering and therapeutic discovery. However, the scarcity of annotated experimental data on binding energy poses a significant challenge for developing computational ...
arxiv
Cloning, preparation and preliminary crystallographic studies of penicillin V acylase autoproteolytic processing mutants [PDF]
, 2005 The crystallization of three catalytically inactive mutants of penicillin Vacylase (PVA) from Bacillus sphaericus in precursor and processed forms is reported.
Brannigan, J A +6 more
core +2 more sources
Mass spectrometry quantification of clusterin in the human brain
Molecular Neurodegeneration, 2012 Background The multifunctional glycoprotein clusterin has been associated with late-onset Alzheimer’s disease (AD). Further investigation to define the role of clusterin in AD phenotypes would be aided by the development of techniques to quantify level ...
Chen Junjun +2 more
doaj +1 more source
Research progress of Nedd4L in cardiovascular diseases
Cell Death Discovery, 2022 Post-translational modifications (PTMs) are a covalent processing process of proteins after translation. Proteins are capable of playing their roles only after being modified, so as to maintain the normal physiological function of cells.
Mohan Li +8 more
doaj +1 more source
To translate, or not to translate: viral and host mRNA regulation by interferon-stimulated genes. [PDF]
, 2015 Type I interferon (IFN) is one of the first lines of cellular defense against viral pathogens. As a result of IFN signaling, a wide array of IFN-stimulated gene (ISG) products is upregulated to target different stages of the viral life cycle.
Li, Melody MH +2 more
core +1 more source
eLife, 2023 Dystroglycan (DG) requires extensive post-translational processing and O-glycosylation to function as a receptor for extracellular matrix (ECM) proteins containing laminin-G (LG) domains.
Hidehiko Okuma +11 more
doaj +1 more source