Results 41 to 50 of about 16,522,946 (324)

Proteinase 3 (PR3)-Antineutrophil Cytoplasmic Antibody in a Patient with Minimal Change Disease: An Unusual Finding [PDF]

Revista Portuguesa de Nefrologia e Hipertensão, 2022
Antineutrophil cytoplasmic antibodies (ANCA) are useful as markers for systemic vasculitis. PR3-ANCA antibodies have been also identified in association with chronic inflammatory and infectious conditions, other autoimmune diseases, malignancy, and ...
Joana Freitas, Inês Sala, João Oliveira, Andreia Campos, Sofia Santos, Josefina Santos, António Cabrita   +6 more
doaj   +1 more source

Proteinase 3 is an IL-32 binding protein [PDF]

Proceedings of the National Academy of Sciences, 2006
IL-32, a recently discovered proinflammatory cytokine with four isoforms, induces IL-1β, TNF-α, IL-6, and chemokines. Here, we used ligand (IL-32α) affinity chromatography in an attempt to isolate an IL-32α soluble receptor or binding protein. Recombinant IL-32α was covalently immobilized on agarose, and preparations of concentrated crude human urinary
Aharon Rabinkov, Daniela Novick, Tania Azam, Charles A. Dinarello, Menachem Rubinstein, Soohyun Kim   +5 more
openaire   +3 more sources

The Functional Role of Membrane Bound Proteinase 3 [PDF]

Biophysical Journal, 2010
Proteinase3 (Pr3) is a serine protease of the neutrophils involved in inflammation processes. Its membrane expression is a risk factor for chronic inflammatory diseases such as vasculitis or emphysema. A recent study demonstrated that Pr3 is co-localized with scramblase at the membrane and might thus be related to the externalization of phosphoserine ...
Nathalie Reuter, Torben Broemstrup
openaire   +2 more sources

Histone modification signature at myeloperoxidase and proteinase 3 in patients with anti-neutrophil cytoplasmic autoantibody-associated vasculitis

Clinical Epigenetics, 2016
Anti-neutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis (AAV) is a systemic autoimmune disease characterized by destructive vascular inflammation.
Jiajin Yang, Heng Ge, Caroline Poulton, S. Hogan, Yichun Hu, B. Jones, Candace D. Henderson, E. McInnis, W. Pendergraft, J. Jennette, R. Falk, D. Ciavatta   +11 more
semanticscholar   +1 more source

Optimizing conditions for enzymatic extraction of sunflower oil

Grasas y Aceites, 1992
Sunflower seed oil was extracted with an enzymatic processes using different hydrolytic enzymes: cellulase, hemicellulase, animal proteinase, acid proteinase, pectinase and pectinex, as compared to enzyme - free aqueous extraction.
F. H. Badr, M. Z. Sitohy
doaj   +1 more source

Proteinase 3. A distinct human polymorphonuclear leukocyte proteinase that produces emphysema in hamsters. [PDF]

Journal of Clinical Investigation, 1988
Studies were designed to explore the possibility that human polymorphonuclear leukocyte granule constituents in addition to elastase (HLE) had the potential to cause emphysema. A two-step purification of three serine proteinases was developed. Granule extract proteins were initially separated by dye-ligand affinity chromatography. Fractions eluted were
John R. Hoidal, R C Kao, Keith M. Skubitz, Nancy G. Wehner, Beulah H. Gray   +4 more
openaire   +3 more sources

Relationship between serologic profile (ANCA type) and clinical features of renal involvement in ANCA-associated vasculitides [PDF]

Терапевтический архив, 2018
Objective. To compare the frequency, clinical features and outcomes of renal involvement in ANCA-associated vasculitides (AAV) in patients with antibodies against proteinase-3 (pr3-ANCA) and myeloperoxidase (MPO-ANCA). Materials and methods.
N M Bulanov, E A Makarov, E M Shchegoleva, A S Zykova, E S Vinogradova, P I Novikov, L V Lysenko(Kozlovskaya), S V Moiseev   +7 more
doaj   +1 more source

Targeted Library of Phosphonic-Type Inhibitors of Human Neutrophil Elastase

Molecules
Despite many years of research, human neutrophil elastase (HNE) still remains an area of interest for many researchers. This multifunctional representative of neutrophil serine proteases is one of the most destructive enzymes found in the human body ...
Karolina Torzyk-Jurowska, Jaroslaw Ciekot, Lukasz Winiarski   +2 more
doaj   +1 more source

Extended Cleavage Specificity of Human Neutrophil Elastase, Human Proteinase 3, and Their Distant Ortholog Clawed Frog PR3—Three Elastases With Similar Primary but Different Extended Specificities and Stability

Frontiers in Immunology, 2018
Serine proteases are major granule constituents of several of the human hematopoietic cell lineages. Four proteolytically active such proteases have been identified in human neutrophils: cathepsin G (hCG), N-elastase (hNE), proteinase 3 (hPR-3), and ...
Zhirong Fu, Michael Thorpe, Srinivas Akula, Gurdeep Chahal, Lars T. Hellman   +4 more
doaj   +1 more source

Proteinase 3-ANCA Vasculitis versus Myeloperoxidase-ANCA Vasculitis.

Journal of the American Society of Nephrology, 2015
In patients with GN or vasculitis, ANCAs are directed against proteinase 3 (PR3) or myeloperoxidase (MPO). The differences between PR3-ANCA-associated vasculitis (AAV) and MPO-AAV described in the past have been supplemented during the last decade.
M. Hilhorst, P. van Paassen, J. C. Tervaert   +2 more
semanticscholar   +1 more source