Results 41 to 50 of about 409,825 (329)

Proteinase 3-antineutrophil cytoplasmic antibody-positive necrotizing crescentic glomerulonephritis complicated by infectious endocarditis: a case report

Journal of Medical Case Reports, 2019
Background Proteinase 3-antineutrophil cytoplasmic antibody has been reported to be positive in 5–10% of cases of renal injury complicated by infective endocarditis; however, histological findings have rarely been reported for these cases.
Katsunori Yanai, Yoshio Kaku, Keiji Hirai, Shohei Kaneko, Saori Minato, Yuko Mutsuyoshi, Hiroki Ishii, Taisuke Kitano, Mitsutoshi Shindo, Haruhisa Miyazawa, Kiyonori Ito, Yuichiro Ueda, Masahiro Hiruta, Susumu Ookawara, Yoshihiko Ueda, Yoshiyuki Morishita   +15 more
doaj   +1 more source

Pyoverdine and proteases affect the response of pseudomonas aeruginosa to gallium in human serum [PDF]

, 2015
Gallium is an iron mimetic which has recently been repurposed as an antibacterial agent due to its capability to disrupt bacterial iron metabolism. In this study, the antibacterial activity of gallium nitrate [Ga(NO3)3] was investigated in complement ...
Bonchi, Carlo, Frangipani, Emanuela, Imperi, Francesco, Visca, Paolo   +3 more
core   +1 more source

Relationship between serologic profile (ANCA type) and clinical features of renal involvement in ANCA-associated vasculitides [PDF]

Терапевтический архив, 2018
Objective. To compare the frequency, clinical features and outcomes of renal involvement in ANCA-associated vasculitides (AAV) in patients with antibodies against proteinase-3 (pr3-ANCA) and myeloperoxidase (MPO-ANCA). Materials and methods.
N M Bulanov, E A Makarov, E M Shchegoleva, A S Zykova, E S Vinogradova, P I Novikov, L V Lysenko(Kozlovskaya), S V Moiseev   +7 more
doaj   +1 more source

Increased Membrane Expression of Proteinase 3 during Neutrophil Adhesion in the Presence of Anti–Proteinase 3 Antibodies [PDF]

Journal of the American Society of Nephrology, 2007
We investigated membrane proteinase 3 (mPR3) expression during TNF-alpha-induced adhesion of neutrophils in the presence of anti-PR3 antibodies, a situation occurring during anti-neutrophil cytoplasmic autoantibodies (ANCA)-associated vasculitis. Three increasing levels of mPR3 expression were observed on the mPR3(+) neutrophil subset after stepwise ...
Soumeya, Brachemi, Agnès, Mambole, Fadi, Fakhouri, Luc, Mouthon, Loïc, Guillevin, Philippe, Lesavre, Lise, Halbwachs-Mecarelli   +6 more
openaire   +2 more sources

Targeted Library of Phosphonic-Type Inhibitors of Human Neutrophil Elastase

Molecules
Despite many years of research, human neutrophil elastase (HNE) still remains an area of interest for many researchers. This multifunctional representative of neutrophil serine proteases is one of the most destructive enzymes found in the human body ...
Karolina Torzyk-Jurowska, Jaroslaw Ciekot, Lukasz Winiarski   +2 more
doaj   +1 more source

Adhesive and degradative properties of human placental cytotrophoblast cells in vitro. [PDF]

, 1989
Human fetal development depends on the embryo rapidly gaining access to the maternal circulation. The trophoblast cells that form the fetal portion of the human placenta have solved this problem by transiently exhibiting certain tumor-like properties ...
Cui, TY, Damsky, CH, Fisher, SJ, Grahl, K, Hartman, L, Tarpey, J, Zhang, GY, Zhang, L   +7 more
core   +3 more sources

The Proteolytic Activity of Neutrophil-Derived Serine Proteases Bound to the Cell Surface Arming Lung Epithelial Cells for Viral Defense

Molecules
The collaboration between cellular proteases and host cells is pivotal in mounting an effective innate immune defense. Of particular interest is the synergistic interaction between cathepsin G (CatG) and neutrophil elastase (NE), which are proteases ...
Akmaral Assylbekova, Maiya Allayarova, Moldir Konysbekova, Amanbek Bekturgan, Aiya Makhanova, Samantha Brown, Norbert Grzegorzek, Hubert Kalbacher, Ruslan Kalendar, Timo Burster   +9 more
doaj   +1 more source

S100A12 Serum Levels and PMN Counts Are Elevated in Childhood Systemic Vasculitides Especially Involving Proteinase 3 Specific Anti-neutrophil Cytoplasmic Antibodies

Frontiers in Pediatrics, 2018
Objectives: Chronic primary systemic vasculitidies (CPV) are a collection of rare diseases involving inflammation in blood vessels, often in multiple organs. CPV can affect adults and children and may be life- or organ-threatening.
Kelly L. Brown, Kelly L. Brown, Joanna M. Lubieniecka, Giulia Armaroli, Katharina Kessel, Kristen M. Gibson, Kristen M. Gibson, Jinko Graham, Dongmeng Liu, Robert E. W. Hancock, Robert E. W. Hancock, Colin J. Ross, Colin J. Ross, Susanne M. Benseler, Raashid A. Luqmani, David A. Cabral, David A. Cabral, Dirk Foell, Christoph Kessel   +18 more
doaj   +1 more source

Comparative aspects of murine proteinase 3

Rheumatology International, 2010
The neutrophilic granule protein proteinase 3 (PR3) is the preferred target antigen of anti-neutrophil cytoplasmic antibodies (ANCA) found in the serum of patients with Wegener's granulomatosis, a systemic small-vessel vasculitis. Due to the lack of data concerning the murine homologue of human PR3, we assessed the neutrophil marker polypeptide PR3 in ...
Relle, Manfred, Thomaidis, Thomas, Galle, Peter R., Schwarting, Andreas   +3 more
openaire   +3 more sources

Manduca sexta Hemolymph Proteinase 21 Activates Prophenoloxidase-activating Proteinase 3 in an Insect Innate Immune Response Proteinase Cascade [PDF]

Journal of Biological Chemistry, 2007
Melanization, an insect immune response, requires a set of hemolymph proteins including pathogen recognition proteins that initiate the response, a cascade of mostly unknown serine proteinases, and phenoloxidase. Until now, only initial and final proteinases in the pathways have been conclusively identified.
Maureen J, Gorman, Yang, Wang, Haobo, Jiang, Michael R, Kanost   +3 more
openaire   +2 more sources