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Chondroitin Sulfate as a Potential Modulator of the Stem Cell Niche in Cornea
Chondroitin sulfate (CS) is an important component of the extracellular matrix in multiple biological tissues. In cornea, the CS glycosaminoglycan (GAG) exists in hybrid form, whereby some of the repeating disaccharides are dermatan sulfate (DS).
Sean Ashworth+15 more
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Chondroitin sulfate (CS), dermatan sulfate (DS) and heparan sulfate (HS) are covalently attached to specific core proteins to form proteoglycans in their biosynthetic pathways.
Shuji Mizumoto, Shuhei Yamada
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ObjectiveInjections of proteoglycan aggrecan (PGA) have been reported to induce axial spondyloarthritis (ax-SpA) in BALB/c mice. It is considered to be a model for radiographic ax-SpA.
Qing Han+21 more
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The Effect of Intense Exercise on Equine Serum Proteoglycan-4/Lubricin
Objective: Local biological and biomechanical-stimuli modulate proteoglycan-4 secretion within synovial joints. For the horse, changes to proteoglycan-4 concentration and function are notable in acute joint injury and osteoarthritis. Proteoglycan-4 (also
Austyn Matheson+5 more
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Extracellular and cell surface chondroitin sulfates (CSs) regulate cancer cell properties, including proliferation and invasion. Thus, it is necessary to understand the mechanisms underlying their roles in cancer.
Satomi Nadanaka+2 more
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The attachment of a variety of Lactobacilli to the mucosal surfaces is accomplished through the interaction of OppA, a superficial bacterial protein also involved in oligopeptide internalization, and the glycosaminoglycan moiety of the proteoglycans that
Carla Martín+9 more
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Small leucine-rich proteoglycans (SLRPs) regulate different processes and undergo significant alterations in various diseases. Colon carcinomas (CCs) are heterogeneous pathologies with important clinical and molecular differences depending on their ...
Maria Pilar Solis-Hernandez+9 more
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Angiotensin II Induces Aortic Rupture and Dissection in Osteoprotegerin‐Deficient Mice
Background The biological mechanism of action for osteoprotegerin, a soluble decoy receptor for the receptor activator of nuclear factor‐kappa B ligand in the vascular structure, has not been elucidated.
Toshihiro Tsuruda+12 more
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Immunolocalization of decorin, a small leucin-rich proteoglycan, in the normal and injured horse tendon [PDF]
The aim of this study was to evaluate the intensity of decorin in normal and the injured equine cadaver limbs. The study was carried out using superficial digital flexor tendon (SDFT) samples harvested from equine cadaver limbs. Randomly assigned left or
Othman J. Ali
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Activin A-Mediated Regulation of XT-I in Human Skin Fibroblasts
Fibrosis is a fundamental feature of systemic sclerosis (SSc) and is characterized by excessive accumulation of extracellular matrix components like proteoglycans (PG) or collagens in skin and internal organs.
Thanh-Diep Ly+7 more
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