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Glycosaminoglycans and Proteoglycans [PDF]
Pharmaceuticals, 2018 In this editorial to MDPI Pharmaceuticals special issue “Glycosaminoglycans and Proteoglycans” we describe in outline the common structural features of glycosaminoglycans and the characteristics of proteoglycans, including the intracellular proteoglycan, serglycin, cell-surface proteoglycans, like syndecans and glypicans, and the extracellular matrix ...
Vitor Pomin, Barbara Mulloy
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Proteoglycans and Osteolysis [PDF]
, 2011 Osteolysis is a complex mechanism resulting from an exacerbated activity of osteoclasts associated or not with a dysregulation of osteoblast metabolism leading to bone loss. This bone defect is not compensated by bone apposition or by apposition of bone matrix with poor mechanical quality.
Marc Baud'huin +13 more
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SVU-International Journal of Veterinary Sciences, 2022 Osteoarthritis (OA) is a degenerative disorder involving the joint, including cartilage and synovial fluids. Recent studies have sought to find curative therapeutics to decrease the adverse effects of OA and relieve associated pain.
Asmaa Z. Shabaan +11 more
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Frontiers in Oncology, 2014 Heparan sulfates (HS) are key components of mammalian cells surface and extracellular matrix. Structure and composition of HS, generated by HS biosynthetic system through non-template driven process, are significantly altered in cancer tissues.
Anastasia V Suhovskih +8 more
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Seminars in Cell & Developmental Biology, 2001 The predominant proteoglycan present in cartilage is the large chondroitin sulfate proteoglycan 'aggrecan'. Following its secretion, aggrecan self-assembles into a supramolecular structure with as many as 50 monomers bound to a filament of hyaluronan.
Warren Knudson, Cheryl B. Knudson
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Cardiovascular Diabetology, 2005 The vascular endothelial basement membrane and extra cellular matrix is a compilation of different macromolecules organized by physical entanglements, opposing ionic charges, chemical covalent bonding, and cross-linking into a biomechanically active ...
Tyagi Suresh C +2 more
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Frontiers in Endocrinology, 2022 PurposeCervical disc herniation (CDH) is one of the most common spinal diseases in modern society; intervertebral disc degeneration (IVDD) has long been considered as its primary cause.
Zhiqi Wang +9 more
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Interplay between Cell-Surface Receptors and Extracellular Matrix in Skin
Biomolecules, 2020 Skin consists of the epidermis and dermis, which are connected by a specialized basement membrane—the epidermal basement membrane. Both the epidermal basement membrane and the underlying interstitial extracellular matrix (ECM) created by dermal ...
Svenja Kleiser, Alexander Nyström
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Biglycan as a potential regulator of tumorgenicity and immunogenicity in K-RAS-transformed cells
OncoImmunology, 2022 The extracellular matrix component biglycan (BGN) plays an essential role in various physiological and pathophysiological processes. A deficient BGN expression associated with reduced immunogenicity was found in HER-2/neu-overexpressing cells.
Karthikeyan Subbarayan +7 more
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Proteoglycan form and function: A comprehensive nomenclature of proteoglycans
Matrix Biology, 2015 We provide a comprehensive classification of the proteoglycan gene families and respective protein cores. This updated nomenclature is based on three criteria: Cellular and subcellular location, overall gene/protein homology, and the utilization of specific protein modules within their respective protein cores.
Iozzo, Renato V., Schäfer, Liliana
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