Results 21 to 30 of about 110,290 (187)

Chemotherapy-Induced Degradation of Glycosylated Components of the Brain Extracellular Matrix Promotes Glioblastoma Relapse Development in an Animal Model

open access: yesFrontiers in Oncology, 2021
Adjuvant chemotherapy with temozolomide (TMZ) is an intrinsic part of glioblastoma multiforme (GBM) therapy targeted to eliminate residual GBM cells.
Alexandra Y. Tsidulko   +11 more
doaj   +1 more source

Heparan sulfate proteoglycan as a cell-surface endocytosis receptor.

open access: yesMatrix Biology, 2014
How various macromolecules are exchanged between cells and how they gain entry into recipient cells are fundamental questions in cell biology with important implications e.g.
H. Christianson, M. Belting
semanticscholar   +1 more source

Extracellular Matrix of Echinoderms

open access: yesMarine Drugs, 2023
This review considers available data on the composition of the extracellular matrix (ECM) in echinoderms. The connective tissue in these animals has a rather complex organization.
Igor Yu. Dolmatov   +1 more
doaj   +1 more source

PTPσ Is a Receptor for Chondroitin Sulfate Proteoglycan, an Inhibitor of Neural Regeneration

open access: yesScience, 2009
Toward Neuronal Regeneration Neurons in the central nervous system that are severed or crushed do not regenerate well. Part of the problem derives from the glial scars left behind after such damage.
Yingjie Shen   +8 more
semanticscholar   +1 more source

Endocan: A novel circulating proteoglycan

open access: yesIndian Journal of Pharmacology, 2014
Endocan is a novel endothelium derived soluble dermatan sulfate proteoglycan. It has the property of binding to a wide range of bioactive molecules associated with cellular signaling and adhesion and thus regulating proliferation, differentiation ...
A. Kali, K. Shetty
semanticscholar   +1 more source

The central role of vascular extracellular matrix and basement membrane remodeling in metabolic syndrome and type 2 diabetes: the matrix preloaded

open access: yesCardiovascular Diabetology, 2005
The vascular endothelial basement membrane and extra cellular matrix is a compilation of different macromolecules organized by physical entanglements, opposing ionic charges, chemical covalent bonding, and cross-linking into a biomechanically active ...
Tyagi Suresh C   +2 more
doaj   +1 more source

Efficient Construction of Atomic-Resolution Models of Non-Sulfated Chondroitin Glycosaminoglycan Using Molecular Dynamics Data

open access: yesBiomolecules, 2020
Glycosaminoglycans (GAGs) are linear, structurally diverse, conformationally complex carbohydrate polymers that may contain up to 200 monosaccharides.
Elizabeth K. Whitmore   +3 more
doaj   +1 more source

Proteoglycan 4 Expression Protects Against the Development of Osteoarthritis

open access: yesScience Translational Medicine, 2013
Proteoglycan 4 protects from age-related and posttraumatic osteoarthritis development. Rubbing Arthritis the Wrong Way There are two main forms of joint inflammation (arthritis). Patients with rheumatoid arthritis develop joint inflammation because of an
M. Z. Ruan   +9 more
semanticscholar   +1 more source

Undervalued ubiquitous proteins

open access: yes4 open, 2019
The role of ubiquitous proteins (UPs) and their corresponding enzymes have been underestimated in carcinogenesis as the focus of much research revolved around measuring mutations and/or other genetic epiphenomena as surrogate markers of cancer and cancer
Brücher Björn L.D.M., Jamall Ijaz S.
doaj   +1 more source

Inflammation and Syndecan-4 Shedding from Cardiac Cells in Ischemic and Non-Ischemic Heart Disease

open access: yesBiomedicines, 2023
Circulating biomarkers reflecting cardiac inflammation are needed to improve the diagnostics and guide the treatment of heart failure patients. The cardiac production and shedding of the transmembrane proteoglycan syndecan-4 is upregulated by innate ...
Mari E. Strand   +10 more
doaj   +1 more source

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