Results 51 to 60 of about 110,290 (187)

Structure-Activity Relationships of Bioengineered Heparin/Heparan Sulfates Produced in Different Bioreactors

Molecules, 2017
Heparin and heparan sulfate are structurally-related carbohydrates with therapeutic applications in anticoagulation, drug delivery, and regenerative medicine.
Ha Na Kim, John M. Whitelock, Megan S. Lord   +2 more
doaj   +1 more source

Mast Cell Proteoglycans [PDF]

Journal of Histochemistry & Cytochemistry, 2012
Mast cells are versatile effector cells of the immune system, contributing to both innate and adaptive immunity toward pathogens but also having profound detrimental activities in the context of inflammatory disease. A hallmark morphological feature of mast cells is their large content of cytoplasmic secretory granules, filled with numerous secretory ...
Elin, Rönnberg, Fabio R, Melo, Gunnar, Pejler   +2 more
openaire   +2 more sources

Structural Variation of Chondroitin Sulfate Chains Contributes to the Molecular Heterogeneity of Perineuronal Nets

Frontiers in Integrative Neuroscience, 2018
Aggrecan, a chondroitin sulfate (CS) proteoglycan, forms lattice-like extracellular matrix structures called perineuronal nets (PNNs). Neocortical PNNs primarily ensheath parvalbumin-expressing inhibitory neurons (parvalbumin, PV cells) late in brain ...
Shinji Miyata, Satomi Nadanaka, Michihiro Igarashi, Hiroshi Kitagawa   +3 more
doaj   +1 more source

Expression of transcription factors KLF2 and KLF4 is induced by the mammalian Golgi stress response

Cell Structure and Function
The Golgi stress response is a homeostatic mechanism that augments Golgi function when Golgi function becomes insufficient (Golgi stress). Glycosylation of the core proteins of proteoglycans is one of the important functions of the Golgi.
Kanae Sasaki, Reishi Tanaka, Iona Miyake, Miyu Sakamoto, Ryuya Tanaka, Azusa Tanaka, Misaki Terami, Ryota Komori, Mai Taniguchi, Sadao Wakabayashi, Hajime Tajima Sakurai, Hiderou Yoshida   +11 more
doaj   +1 more source

Quantitative magnetic resonance imaging of articular cartilage in osteoarthritis [PDF]

European Cells & Materials, 2007
Magnetic resonance imaging of articular cartilage has recently been recognized as a tool for the characterization of cartilage morphology, biochemistry and function.
G Blumenkrantz, S Majumdar
doaj  

Biology and Biomechanics of the Heart Valve Extracellular Matrix

Journal of Cardiovascular Development and Disease, 2020
Heart valves are dynamic structures that, in the average human, open and close over 100,000 times per day, and 3 × 109 times per lifetime to maintain unidirectional blood flow.
Karthik M. Kodigepalli, Kaitlyn Thatcher, Toni West, Daniel P. Howsmon, Frederick J. Schoen, Michael S. Sacks, Christopher K. Breuer, Joy Lincoln   +7 more
doaj   +1 more source

Serum decorin and biglycan levels as predictive biomarkers for lung fibrosis severity and mortality risk in COVID-19 patients

Frontiers in Medicine
IntroductionIndividuals experiencing severe symptoms of COVID-19 are at the greatest risk of developing post-COVID lung fibrosis, which significantly impacts long-term health outcomes.
Shaaf Ahmad, Kaleem Maqsood, Farwa Liaqat, Nabila Roohi   +3 more
doaj   +1 more source

Proteoglycans and Osteolysis [PDF]

, 2011
Osteolysis is a complex mechanism resulting from an exacerbated activity of osteoclasts associated or not with a dysregulation of osteoblast metabolism leading to bone loss. This bone defect is not compensated by bone apposition or by apposition of bone matrix with poor mechanical quality.
Baud'Huin, Marc, Charrier, Céline, Bougras, Gwenola, Brion, Régis, Lezot, Frédéric, Padrines, Marc, Heymann, Dominique   +6 more
openaire   +4 more sources

Increased expression of the NG2 chondroitin-sulfate proteoglycan after brain injury

Journal of Neuroscience, 1994
Injury to the adult mammalian CNS results in reactive changes among the glial cells surrounding the site of damage. Recently, an unusual class of glial cells has been identified within the intact adult rat cerebellum on the basis of the expression of the
J. Levine
semanticscholar   +1 more source

Molecular cloning of syndecan, an integral membrane proteoglycan

Journal of Cell Biology, 1989
We describe cDNA clones for a cell surface proteoglycan that bears both heparan sulfate and chondroitin sulfate and that links the cytoskeleton to the interstitial matrix.
Scott Saunders, M. Jalkanen, S. O'Farrell, Merton Berntield   +3 more
semanticscholar   +1 more source