Protein Homeostasis in Amyotrophic Lateral Sclerosis: Therapeutic Opportunities? [PDF]
Frontiers in Molecular Neuroscience, 2017 Protein homeostasis (proteostasis), the correct balance between production and degradation of proteins, is essential for the health and survival of cells.
Pamela J. Shaw +3 more
doaj +4 more sources
The proteostasis network and its decline in ageing
Nature reviews. Molecular cell biology, 2019 Ageing is a major risk factor for the development of many diseases, prominently including neurodegenerative disorders such as Alzheimer disease and Parkinson disease.
Hartl, F., Hipp, M., Kasturi, P.
core +2 more sources
Phenylhydrazone-based endoplasmic reticulum proteostasis regulator compounds with enhanced biological activity [PDF]
eLifePharmacological enhancement of endoplasmic reticulum (ER) proteostasis is an attractive strategy to mitigate pathology linked to etiologically diverse protein misfolding diseases.
Gabriel M Kline +10 more
doaj +2 more sources
Targeting proteostasis for cancer therapy: current advances, challenges, and future perspectives [PDF]
Molecular CancerThe proteostasis network plays a pivotal role in enabling tumor cells to maintain protein homeostasis, mitigate proteotoxic stress, and promote tumor progression and resistance to therapeutic interventions.
Chenliang Zhang +4 more
doaj +2 more sources
Modulation of the proteostasis network promotes tumor resistance to oncogenic KRAS inhibitors
Science, 2023 Despite substantial advances in targeting mutant KRAS, tumor resistance to KRAS inhibitors (KRASi) remains a major barrier to progress. Here, we report proteostasis reprogramming as a key convergence point of multiple KRASi-resistance mechanisms ...
Xiangdong Lv +38 more
semanticscholar +1 more source
The Proteostasis Network: A Global Therapeutic Target for Neuroprotection after Spinal Cord Injury
Cells, 2022 Proteostasis (protein homeostasis) is critical for cellular as well as organismal survival. It is strictly regulated by multiple conserved pathways including the ubiquitin-proteasome system, autophagy, the heat shock response, the integrated stress ...
Scott R. Whittemore +4 more
doaj +1 more source
dCubilin- or dAMN-mediated protein reabsorption in Drosophila nephrocytes modulates longevity
Disease Models & Mechanisms, 2021 Aging is a multifaceted process regulated by multiple cellular pathways, including the proteostasis network. Pharmacological or genetic enhancement of the intracellular proteostasis network extends lifespan and prevents age-related diseases. However, how
Xiaoming Feng +8 more
doaj +1 more source
Protein homeostasis in aging and cancer
Frontiers in Cell and Developmental Biology, 2023 Aging is a major risk factor for cancer development. As dysfunction in protein homeostasis, or proteostasis, is a universal hallmark of both the aging process and cancer, a comprehensive understanding of the proteostasis system and its roles in aging and
Xiao-Qiong Chen +5 more
doaj +1 more source
Cells, 2023 Sarcopenia is a debilitating skeletal muscle disease that accelerates in the last decades of life and is characterized by marked deficits in muscle strength, mass, quality, and metabolic health.
H. Paez, Christopher R Pitzer, S. Alway
semanticscholar +1 more source
Proteostasis and neurodegeneration: a closer look at autophagy in Alzheimer's disease
Frontiers in Aging Neuroscience, 2023 Alzheimer's disease (AD) is characterized by the accumulation of misfolded amyloid-beta and tau proteins. Autophagy acts as a proteostasis process to remove protein clumps, although it progressively weakens with aging and AD, thus facilitating the ...
Haleh Barmaki +2 more
semanticscholar +1 more source