Results 91 to 100 of about 56,365 (241)
Thermodynamic bounds on the ultra- and infra-affinity of Hsp70 for its
substrates [PDF]
, 2017 The 70 kDa Heat Shock Proteins Hsp70 have several essential functions in
living systems, such as protecting cells against protein aggregation, assisting
protein folding, remodeling protein complexes and driving the translocation
into organelles.Hartich, David, Nguyen, Basile, Rios, Paolo De Los, Seifert, Udo +3 morecore +2 more sourcesDevelopment and Structural Characterization of UTE‐156, a Covalent Inhibitor of the VCP/p97 AAA+ ATPase
Advanced Science, EarlyView.The AAA+ ATPase Valosin‐containing protein (VCP/p97) regulates protein homeostasis by unfolding ubiquitinated substrates. Here, we describe UTE‐156, a novel irreversible covalent inhibitor that modifies Cys522 in the D2 ATPase motor domain. Although its pharmacochemical limitations preclude immediate therapeutic use, UTE‐156 serves as a valuable ...Daniela Tamayo‐Jaramillo, Subramanya Hegde, Xuan Jia, Kimberly Coffman, Hariprasad Vankayalapati, David Bearss, Kevin B. Jones, Alex W. Stark, Peter S. Shen +8 morewiley +1 more sourceThe Nuclear Lamina: Protein Accumulation and Disease
Biomedicines, 2020 Cellular health is reliant on proteostasis—the maintenance of protein levels regulated through multiple pathways modulating protein synthesis, degradation and clearance. Loss of proteostasis results in serious disease and is associated with aging.Carla Almendáriz-Palacios, Zoe E. Gillespie, Matthew Janzen, Valeria Martinez, Joanna M. Bridger, Troy A. A. Harkness, Darrell D. Mousseau, Christopher H. Eskiw +7 moredoaj +1 more sourceT Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities
Advanced Science, EarlyView.T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun +7 morewiley +1 more sourceImpairment of lipid homeostasis causes lysosomal accumulation of endogenous protein aggregates through ESCRT disruption
eLifeProtein aggregation increases during aging and is a pathological hallmark of many age-related diseases. Protein homeostasis (proteostasis) depends on a core network of factors directly influencing protein production, folding, trafficking, and degradation.John Yong, Jacqueline E Villalta, Ngoc Vu, Matthew A Kukurugya, Niclas Olsson, Magdalena Preciado López, Julia R Lazzari-Dean, Kayley Hake, Fiona E McAllister, Bryson D Bennett, Calvin H Jan +10 moredoaj +1 more sourceNext-generation proteasome inhibitor oprozomib synergizes with modulators of the unfolded protein response to suppress hepatocellular carcinoma [PDF]
, 2016 Hepatocellular carcinoma (HCC) responds poorly to conventional systemic therapies. The first-in-class proteasome inhibitor bortezomib has been approved in clinical use for hematologic malignancies and has shown modest activity in solid tumors, including ...Bogaerts, Eliene, Coucke, Céline, Devisscher, Lindsey, Geerts, Anja, Laukens, Debby, Libbrecht, Louis, Paridaens, Annelies, Raevens, Sarah, Van Steenkiste, Christophe, Van Vlierberghe, Hans, Vandewynckel, Yves-Paul, Vandierendonck, Aster, Verhelst, Xavier +12 morecore +2 more sourcesThe Age‐Dependent Resident Myonuclear Multi‐Omic Response to an Acute Skeletal Muscle Hypertrophic Stimulus in Mice
Advanced Science, EarlyView.Resident myonuclei are the molecular “control centers” for large multinuclear muscle fibers. It is presumed that, with aging, these control centers become compromised and contribute to delayed or blunted muscle adaptive potential. This study is a detailed roadmap that exposes how young versus aged myonuclei respond to a hypertrophic loading stimulus ...Pieter J. Koopmans, Ronald G. Jones III, Ana Regina Cabrera, Francielly Morena, Nicholas P. Greene, John J. McCarthy, Ahmed Ismaeel, Yuan Wen, Kevin A. Murach +8 morewiley +1 more sourceThe disruption of proteostasis in neurodegenerative diseases [PDF]
, 2015 Cells count on surveillance systems to monitor and protect the cellular proteome which, besides being highly heterogeneous, is constantly being challenged by intrinsic and environmental factors. 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Ting L, et al., Neef DW, Jaeger AM, Gomez-Pastor R, et al., Nishitoh H, Matsuzawa A, Tobiume K, et al., Nixon RA, Nollen EAA, Garcia SM, van Haaften G, et al., Novoa I, Zeng H, Harding HP, et al., Okada T, Yoshida H, Akazawa R, et al., Oliveberg M, Wolynes PG, Olzscha H, Schermann SM, Woerner AC, et al., Onuchic JN, Wolynes PG, Oosten-Hawle P van, Morimoto RI, Oyadomari S, Yun C, Fisher EA, et al., Parsell DA, Kowal AS, Singer MA, et al., Parsell DA, Lindquist S, Paulson HL, Perez MK, Trottier Y, et al., Powers ET, Balch WE, Powers ET, Morimoto RI, Dillin A, et al., Powers MV, Workman P, Pradel E, Zhang Y, Pujol N, et al., Prahlad V, Cornelius T, Morimoto RI, Prahlad V, Morimoto RI, Pratt WB, Gestwicki JE, Osawa Y, et al., Raineri E, Ribeca P, Serrano L, et al., Rampelt H, Kirstein-Miles J, Nillegoda NB, et al., Reidy M, Miot M, Masison DC, Reissmann S, Parnot C, Booth CR, et al., Riedel M, Goldbaum O, Schwarz L, et al., Rousseau F, Serrano L, Schymkowitz JWH, Runkel ED, Liu S, 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Xie J, Tang L, Lu L, et al., Xu D, Zalmas LP, La Thangue NB, Xu Y, Cai M, Yang Y, et al., Xu Z, Horwich AL, Sigler PB, Yamamoto K, Sato T, Matsui T, et al., Ye J, Rawson RB, Komuro R, et al., Yoshida H, Matsui T, Yamamoto A, et al., Yoshida H, Oku M, Suzuki M, et al., Yoshida H, Uemura A, Mori K, Young JC, Barral JM, Ulrich Hartl F, Yu A, Shibata Y, Shah B, et al., Zhang Y, Lu H, Bargmann CI, Zhao Q, Wang J, Levichkin IV, et al., Zietkiewicz S, Lewandowska A, Stocki P, et al., Zolkiewski M, Zou J, Guo Y, Guettouche T, et al. +251 morecore +2 more sourcesSystematic Engineering of Proteases in Saccharopolyspora Spinosa Reveals Synergistic Enhancement of Spinosad Biosynthesis via Substrate Flux Optimization
Advanced Science, EarlyView.ARTP mutagenesis yielded Saccharopolyspora spinosa mutant D184 with improved extracellular nitrogen utilization. An integrated workflow of protease genetic manipulation, multi‐omics, and rational synergy design pinpointed a pepP‐clpP‐htpX synergistic triangular combination.Duo Jin, Wangqiong Chen, Danlu Yang, Qing Liu, Baolong Bai, Zirui Dai, Xirong Liu, Zirong Zhu, Jie Rang, Liqiu Xia +9 morewiley +1 more source
