Results 141 to 150 of about 62,588 (334)

Next-generation proteasome inhibitor oprozomib synergizes with modulators of the unfolded protein response to suppress hepatocellular carcinoma [PDF]

, 2016
Hepatocellular carcinoma (HCC) responds poorly to conventional systemic therapies. The first-in-class proteasome inhibitor bortezomib has been approved in clinical use for hematologic malignancies and has shown modest activity in solid tumors, including ...
Bogaerts, Eliene, Coucke, Céline, Devisscher, Lindsey, Geerts, Anja, Laukens, Debby, Libbrecht, Louis, Paridaens, Annelies, Raevens, Sarah, Van Steenkiste, Christophe, Van Vlierberghe, Hans, Vandewynckel, Yves-Paul, Vandierendonck, Aster, Verhelst, Xavier   +12 more
core   +2 more sources

Spatially Resolved Multiomics Reveals Metabolic Remodeling and Autophagy Activation in Adamantinomatous Craniopharyngiomas

Advanced Science, EarlyView.
Multiomics integration analysis reveals the “cystic fluid–tumor cell” metabolic coupling that mediates active choline/ethanolamine uptake of tumor cells from cystic fluid and PC/PE synthesis pathways reprogramming that mediating autophagy pathway activation within ACP. ABSTRACT Adamantinomatous craniopharyngioma (ACP), a benign yet highly recurrent and
Dongting Chen, Yahui Gao, Yulin Wang, Ting Lei, Zheng Qu, Yuhan An, Jiaxu Fu, Xin Li, Fangjun Liu, Yan Li   +9 more
wiley   +1 more source

Ageing exacerbates ribosome pausing to disrupt cotranslational proteostasis

Nature, 2022
K. Stein, Fábian Morales-Polanco, Joris van der Lienden, T. K. Rainbolt, J. Frydman   +4 more
semanticscholar   +1 more source

Probing the Proteostasis Network

Chemistry & Biology, 2010
PTI has built itself up as an entity that can test the concept of proteostasis modulators. The company is using its capabilities in transcriptional, proteomic, and functional profiling to probe the proteostasis network in human diseases. “The goal of all of this work is to increase the health span, the number of years we are healthy,” says Kelly.To ...
openaire   +2 more sources

Thermally Gated Dual‐Cascade Nanozyme for Enhanced Mild‐Temperature Photothermal Therapy

Advanced Science, EarlyView.
A thermo‐responsive cascade nanozyme (Ru‐GOx‐PNN) synergistically enhances mild photothermal therapy by dual suppression of HSP70 through ROS‐induced lipid peroxidation and ATP depletion. This intelligent system effectively overcomes thermotolerance and amplifies apoptosis, offering a safe and precise strategy for tumor treatment.
Shuyu Wang, Shenghui Wang, Mengyuan Cao, Lulu Wang, Wei Jiang, Xiyun Yan, Ying Liu, Bing Jiang   +7 more
wiley   +1 more source

Thermodynamic bounds on the ultra- and infra-affinity of Hsp70 for its substrates [PDF]

, 2017
The 70 kDa Heat Shock Proteins Hsp70 have several essential functions in living systems, such as protecting cells against protein aggregation, assisting protein folding, remodeling protein complexes and driving the translocation into organelles.
Hartich, David, Nguyen, Basile, Rios, Paolo De Los, Seifert, Udo   +3 more
core   +2 more sources

Redox regulation of proteostasis

Journal of Biological Chemistry
Oxidants produced through endogenous metabolism or encountered in the environment react directly with reactive sites in biological macromolecules. Many proteins, in particular, are susceptible to oxidative damage, which can lead to their altered structure and function.
Long Duy Duong, James D. West, Kevin A. Morano   +2 more
openaire   +2 more sources

Chaperone‐Mediated Autophagic Degradation of USP9X in Macrophages Exacerbates Postmyocardial Infarction Inflammation and Cardiac Dysfunction

Advanced Science, EarlyView.
This study demonstrates that inflammatory stimuli induce the acetylation‐triggered, chaperone‐mediated autophagic degradation of ubiquitin‐specific peptidase 9 X‐linked (USP9X) in macrophages. USP9X acts as a macrophage “inflammation switch” after myocardial infarction (MI). USP9X loss destabilizes tumor necrosis factor receptor‐associated factor (TRAF)
Biqing Wang, Xiangheng Cai, Mengqi Li, Xue Liu, Junhui Xue, Ye Liu, Ding Ai, Xinyang Hu   +7 more
wiley   +1 more source

Remodeling the endoplasmic reticulum proteostasis network restores proteostasis of pathogenic GABAA receptors

PLOS ONE, 2018
Biogenesis of membrane proteins is controlled by the protein homeostasis (proteostasis) network. We have been focusing on protein quality control of γ-aminobutyric acid type A (GABAA) receptors, the major inhibitory neurotransmitter-gated ion channels in mammalian central nervous system.
Yan-Lin Fu, Dong-Yun Han, Ya-Juan Wang, Xiao-Jing Di, Hai-Bo Yu, Ting-Wei Mu   +5 more
openaire   +5 more sources

Ubiquitin sets the timer: impacts on aging and longevity [PDF]

, 2014
Protein homeostasis is essential for cellular function, organismal growth and viability. Damaged and aggregated proteins are turned over by two major proteolytic routes of the cellular quality-control pathways: the ubiquitin-proteasome system and ...
A Ben-Zvi, AC Carrano, AM Pickering, BH Rhie, CJ Kenyon, D Komander, D Vilchez, EB Taylor, F Madeo, H Digaleh, HJ Huang, HY Liu, JF Dice, JM Heo, K Kuhlbrodt, KP Choe, LR Lapierre, M Gaczynska, N Safren, NF Villeneuve, O Matilainen, PJ Lim, Q Chen, S Henis-Korenblit, SF Leiser, Thorsten Hoppe, U Kruegel, V Andersson, VA Vernace, Y Han, Éva Kevei   +30 more
core   +1 more source