Results 11 to 20 of about 62,588 (334)

Proteostasis signatures in human diseases.

PLoS Computational Biology
The protein homeostasis (proteostasis) network maintains the proteome in a functional state. Although this network has been comprehensively mapped, its perturbations in disease remain incompletely characterised.
Christine M Lim, Michele Vendruscolo
doaj   +3 more sources

TFEB regulates lysosomal proteostasis [PDF]

Human Molecular Genetics, 2013
Loss-of-function diseases are often caused by destabilizing mutations that lead to protein misfolding and degradation. Modulating the innate protein homeostasis (proteostasis) capacity may lead to rescue of native folding of the mutated variants, thereby
Abrahamov, Alberto di Ronza, Altarescu, Ashley Ake, Balch, Balch, Beutler, Brown, Cho, Christophe, Desnick, Dionisi-Vici, Fan Wang, Ferrao-Gonzales, Fu, Futerman, Gennarino, Gieselmann, Ginzburg, Grabowski, Grabowski, Grace, Hruska, Huang, Karageorgos, Kim, Kiselyov, Koprivica, Krivit, Krivit, Krivit, Laura Segatori, Lieberman, Lopes, Lu, Lu, Lubke, Ma, Maley, Marco Sardiello, Marzia Savini, Medina, Meikle, Michelakakis, Mu, Mu, Neufeld, Nigg, Ong, Palmieri, Parr, Powers, Reczek, Rohrbach, Ron, Roversi, Sands, Sardiello, Sardiello, Sawkar, Sawkar, Schmitz, Schueler, Seregin, Settembre, Shapiro, Steingrimsson, Subramanian, Tropak, Tsuji, Tsuji, Tsunemi, Vandesompele, Wang, Wang, Wang, Wei, Welch, Wensi Song, Yu, Zhao   +80 more
core   +5 more sources

Proteostasis During Cerebral Ischemia [PDF]

Frontiers in Neuroscience, 2019
Cerebral ischemia is a complex pathology involving a cascade of cellular mechanisms, which deregulate proteostasis and lead to neuronal death. Proteostasis refers to the equilibrium between protein synthesis, folding, transport, and protein degradation ...
Audrey M. Thiebaut, Elodie Hedou, Stefan J. Marciniak, Stefan J. Marciniak, Denis Vivien, Denis Vivien, Benoit D. Roussel   +6 more
doaj   +3 more sources

Multi-platform proteomic analysis of Alzheimer’s disease cerebrospinal fluid and plasma reveals network biomarkers associated with proteostasis and the matrisome

bioRxiv, 2022
Robust and accessible biomarkers that can capture the heterogeneity of Alzheimer’s disease and its diverse pathological processes are urgently needed. Here, we undertook an investigation of Alzheimer’s disease cerebrospinal fluid (CSF) and plasma from ...
E. Dammer, Lingyan Ping, D. Duong, Erica Modeste, N. Seyfried, J. Lah, A. Levey, Erik C.B. Johnson   +7 more
semanticscholar   +1 more source

Dynamic intracellular exchange of nanomaterials’ protein corona perturbs proteostasis and remodels cell metabolism

Proceedings of the National Academy of Sciences of the United States of America, 2022
Significance This study analyzed the dynamic protein corona on the surface of nanoparticles as they traversed from blood to cell lysosomes and escaped from lysosomes to cytoplasm in the target cells.
Rong Cai, Jiayu Ren, Mengyu Guo, T. Wei, Ying Liu, Chunyu Xie, P. Zhang, Zhiling Guo, Andrew J Chetwynd, P. Ke, I. Lynch, Chunying Chen   +11 more
semanticscholar   +1 more source

Regulation of the proteostasis network by the neuronal system

Frontiers in Molecular Biosciences, 2023
The protein homeostasis (proteostasis) network is a nexus of molecular mechanisms that act in concert to maintain the integrity of the proteome and ensure proper cellular and organismal functionality.
Huadong Zhu, Ehud Cohen
doaj   +1 more source

Cell surface protein aggregation triggers endocytosis to maintain plasma membrane proteostasis

Nature Communications, 2023
How cells respond to denaturation of extracellular protein domains remained largely unknown. Here, authors describe an aggregation-dependent endocytosis pathway, facilitating uptake and degradation of antibody- and stress-induced protein aggregates.
David Paul, Omer Stern, Y. Vallis, Jatinder Dhillon, A. Buchanan, H. McMahon   +5 more
semanticscholar   +1 more source

Proteostasis impairment in ALS [PDF]

Brain Research, 2016
In physiological conditions the maintenance of the cellular proteome is a prerequisite for optimal cell functioning and cell survival. Additionally, cells need to constantly sense and adapt to their changing environment and associated stressors.
Céline, Ruegsegger, Smita, Saxena
openaire   +2 more sources

Immunoproteasome-specific subunit PSMB9 induction is required to regulate cellular proteostasis upon mitochondrial dysfunction

Nature Communications, 2023
Perturbed cellular protein homeostasis (proteostasis) and mitochondrial dysfunction play an important role in neurodegenerative diseases, however, the interplay between these two phenomena remains unclear.
Minji Kim, R. Serwa, Lukasz Samluk, I. Suppanz, A. Kodroń, T. Stępkowski, Praveenraj Elancheliyan, Biniyam Tsegaye, S. Oeljeklaus, Michał Wasilewski, B. Warscheid, A. Chacińska   +11 more
semanticscholar   +1 more source

Proteostasis failure exacerbates neuronal circuit dysfunction and sleep impairments in Alzheimer’s disease

Molecular Neurodegeneration, 2023
Failed proteostasis is a well-documented feature of Alzheimer’s disease, particularly, reduced protein degradation and clearance. However, the contribution of failed proteostasis to neuronal circuit dysfunction is an emerging concept in neurodegenerative
C. D. Morrone, Radha Raghuraman, S. A. Hussaini, W. H. Yu   +3 more
semanticscholar   +1 more source