Results 61 to 70 of about 62,588 (334)
TP53 R249S mutation in hepatic organoids captures the predisposing cancer risk
Hepatology, EarlyView., 2022 The systematic approach in elucidating the gain‐of‐function (GOF) roles of TP53 mutations in early liver carcinogenesis. Unique downstream targets of TP53 L3 mutations were identified from chormatin immunoprecipitation sequencing in HCC cell lines, followed by a series of validation assays to substantiate the exclusive transcriptional regulations ...
Yin Kau Lam +10 more
wiley +1 more source
Cell aging preserves cellular immortality in the presence of lethal levels of damage. [PDF]
, 2019 Cellular aging, a progressive functional decline driven by damage accumulation, often culminates in the mortality of a cell lineage. Certain lineages, however, are able to sustain long-lasting immortality, as prominently exemplified by stem cells.
Chao, Lin +4 more
core +3 more sources
Quality Control of Mitochondrial Proteostasis [PDF]
Cold Spring Harbor Perspectives in Biology, 2011 A decline in mitochondrial activity has been associated with aging and is a hallmark of many neurological diseases. Surveillance mechanisms acting at the molecular, organellar, and cellular level monitor mitochondrial integrity and ensure the maintenance of mitochondrial proteostasis. Here we will review the central role of mitochondrial chaperones and
Baker, M., Tatsuta, T., Langer, T.
openaire +3 more sources
Neural Plasticity, 2018 Proteostasis involves processes that are fundamental for neural viability. Thus, protein misfolding and the formation of toxic aggregates at neural level, secondary to dysregulation of the conservative mechanisms of proteostasis, are associated with ...
Pablo Olivero +8 more
doaj +1 more source
Unravelling druggable signalling networks that control F508del-CFTR proteostasis
eLife, 2015 Cystic fibrosis (CF) is caused by mutations in CF transmembrane conductance regulator (CFTR). The most frequent mutation (F508del-CFTR) results in altered proteostasis, that is, in the misfolding and intracellular degradation of the protein.
Ramanath Narayana Hegde +15 more
doaj +1 more source
Fluorodeoxyuridine improves Caenorhabditis elegans proteostasis independent of reproduction onset. [PDF]
PLoS ONE, 2014 Protein homeostasis (proteostasis) networks are dynamic throughout the lifespan of an organism. During Caenorhabditis elegans adulthood, the maintenance of metastable proteins and the activation of stress responses are inversely associated with germline ...
Naama Feldman +2 more
doaj +1 more source
Proteasome Inhibitors: Harnessing Proteostasis to Combat Disease [PDF]
, 2020 The proteasome is the central component of the main cellular protein degradation pathway. During the past four decades, the critical function of the proteasome in numerous physiological processes has been revealed, and proteasome activity has been linked
Li, Jing, Sherman, David J.
core
Four-dimensional nuclear speckle phase separation dynamics regulate proteostasis
Science Advances, 2022 A cell-autonomous 12-hour clock coordinates nuclear speckle LLPS with proteostasis control.
William A Dion +10 more
semanticscholar +1 more source
Prion, 2008 Infectious amyloid forms of the release factor, Sup35, comprise the yeast prion [PSI+]. This protein-based unit of inheritance is an evolutionary capacitor able to release cryptic genetic variation during environmental stress and generate potentially beneficial phenotypes.
Elizabeth A, Sweeny, James, Shorter
openaire +2 more sources
The Autophagy-Lysosomal Pathways and Their Emerging Roles in Modulating Proteostasis in Tumors
Cells, 2018 In normal physiological condition, the maintenance of cellular proteostasis is a prerequisite for cell growth, functioning, adapting to changing micro-environments, and responding to extracellular stress.
Zhen Dong, Hongjuan Cui
doaj +1 more source