Results 91 to 100 of about 105,223 (244)

Hepatitis B Virus RNA Predicts Hepatocellular Carcinoma Despite Viral Suppression

Alimentary Pharmacology &Therapeutics, EarlyView.
Serum HBV RNA levels at viral suppression predict HCC development in nucleos(t)ide analogue‐treated patients with chronic hepatitis B, outperforming Hepatitis B core‐related antigen alone. ABSTRACT Background Despite achieving undetectable hepatitis B virus (HBV) DNA levels with nucleos(t)ide analogue (NA) therapy, patients with chronic hepatitis B ...
Takashi Kumada, Hidenori Toyoda, Satoshi Yasuda, Yuichi Koshiyama, Takanori Ito, Tomoyuki Akita, Junko Tanaka   +6 more
wiley   +1 more source

Post‐Banding Ulcer Bleeding After Endoscopic Ligation: Incidence, Risk Factors and Outcomes in Patients With Cirrhosis

Alimentary Pharmacology &Therapeutics, EarlyView.
A PBUB is a rare but often fatal complication of endoscopic variceal band ligation. The relevant risk factors contributing to PBUB are unknown and consequently there are no effective preemptive strategies. This study highlights kidney disease as a predictor of PBUB together with the well‐established higher risk for urgent band ligation.
Maria de Brito Nunes, Matthias Knecht, Jonas Schropp, Reiner Wiest, Jaume Bosch, Annalisa Berzigotti   +5 more
wiley   +1 more source

Novel drugs approved by the EMA, the FDA and the MHRA in 2025: A year in review

British Journal of Pharmacology, EarlyView.
Abstract In the 2025 novel drug mini‐review, one can take a full measure of the ingenuity that underlies current drug design and development, despite the year's smaller harvest (46 novel drugs) compared to 2024 (53) and 2023 (70). 54% of the novel drugs are first‐in‐class (FIC).
Andreas Papapetropoulos, Stavros Topouzis, Steve P. H. Alexander, Miriam M. Cortese‐Krott, Zsuzsanna Helyes, Kirill Martemyanov, Claudio Mauro, Nithyanandan Nagercoil, Reynold A. Panettieri Jr, Hemal H. Patel, Rainer Schulz, Barbara Stefanska, Gary J. Stephens, Nathalie Vergnolle, Xin Wang, Stephen Ward, Péter Ferdinandy   +16 more
wiley   +1 more source

The role of genetic hemostasis gene variants in the development of venous thrombosis in patients with atherosclerosis after COVID-19 infection

Инфекция и иммунитет
Introduction. The new coronavirus infection (COVID-19) is one of the most important problems in modern medicine. One of the etiopathogenetic COVID-19 arms is presented by a disorder in the hemostasis system, which can be associated with emerging ...
O. A Perevezentsev, I. S. Mamedov, D. V. Burtsev   +2 more
doaj   +1 more source

Neonates born at term with periventricular haemorrhagic infarction: Risk factors and clinical presentation

Developmental Medicine &Child Neurology, EarlyView.
This case series describes infants born near term with periventricular hemorrhagic infarction (PVHI), highlighting seizures as a common early symptom. Neonatal complications during delivery and pro‐thrombotic genetic mutations were slightly more common. MRI‐classified involvement was predominantly in the caudate vein territory.
Aleksandra Zaykova, Jeroen Dudink, Floris Groenendaal, Maarten H. Lequin, Manon J.N.L. Benders, Maria Luisa Tataranno, Elise Roze   +6 more
wiley   +1 more source

Determination of Prothrombin

Experimental Biology and Medicine, 1939
The author1 developed a quantitative method for the determination of prothrombin based on the principle that the clotting time of blood or plasma is a quantitative measure of the prothrombin concentration provided an excess of thrombin and a constant concentration of calcium are present. For convenience and accuracy, the blood is oxa-lated and the test
openaire   +1 more source

Healthcare Resource Utilisation and Cost of Obesity and Related Complications in the United States: A Systematic Literature Review

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aim Obesity is an increasingly prevalent, chronic, heterogeneous disease, associated with a variety of obesity‐related complications (ORCs). This systematic literature review assessed US healthcare resource utilisation (HCRU) and costs (direct and indirect) for people living with obesity (PwO) or overweight and ORCs.
Jaime P. Almandoz, Jamy D. Ard, Chellse Gazda, Shenelle Edwards‐Hampton   +3 more
wiley   +1 more source

Role of prothrombin complex concentrate in the severe trauma patient

Frontiers in Medicine, 2022
Juan José Egea-Guerrero, Juan José Egea-Guerrero, Manuel Quintana-Diaz   +2 more
doaj   +1 more source

Inherited thrombophilia in a Han Chinese family caused by prothrombin Ile441Met mutation

Research and Practice in Thrombosis and Haemostasis
Background: Inherited thrombophilia (IT) is a genetically determined predisposition to thromboembolic events. Beyond the well-known G20210A mutation, there has been limited research on other prothrombin mutations in the Chinese population.
Si-Yuan Wen, Fei-Fei Chen, Ji-De Chen, Pan Tao, Chi Meng, Jing Huang, Xin Kang, Wei Chen, Chang-Qing Zhou   +8 more
doaj   +1 more source

Successful use of haemoperfusion therapy in an adult horse with hepatic encephalopathy and cholangiohepatitis

Equine Veterinary Education, EarlyView.
Summary A 4‐year‐old, 520 kg, American Quarter Horse broodmare, approximately 90 days in foal, was presented to Texas A&M University Teaching Hospital for suspected liver disease. Based on clinicopathological values and hepatic abnormalities noted ultrasonographically, the mare was presumptively diagnosed with cholangiohepatitis.
A. C. Trimble, S. H. White‐Springer, S. Alpini, E. Rumfola, A. N. DiSilvestro, Y. Ueda, K. Hobbs   +6 more
wiley   +1 more source