Results 101 to 110 of about 219,018 (388)

Neck‐vein thrombosis during spaceflight

British Journal of Clinical Pharmacology, EarlyView.
Spaceflight imposes unique environmental challenges, including weightlessness, increased radiation exposure and confinement, which can lead to unexpected health effects. One such example is neck‐vein thrombosis, a condition rarely seen on Earth without predisposing factors such as venous catheters or infections.
Ulrich Limper, Jens Jordan
wiley   +1 more source

Coagulation state monitoring of burn patients in Duhok governorate, Iraq

Indian Journal of Burns
Background and Objective: Patients with severe burns have coagulation abnormalities that are similar to those seen in sepsis or acute trauma patients. Patients with severe burns who experience coagulopathy exhibit abnormalities in procoagulants as well ...
Beri Adil Tawfeq, Bizav Naji Rasheed
doaj   +1 more source

Prothrombin complex concentrate in the reduction of blood loss during orthotopic liver transplantation: PROTON-trial

BMC Surgery, 2013
BackgroundIn patients with cirrhosis, the synthesis of coagulation factors can fall short, reflected by a prolonged prothrombin time. Although anticoagulants factors are decreased as well, blood loss during orthotopic liver transplantation can still be ...
Freeha Arshad, B. Ickx, Rachel T van Beem, W. Polak, F. Grüne, F. Nevens, M. Ilmakunnas, A. Koivusalo, H. Isoniemi, P. Strengers, H. Groen, H. Hendriks, T. Lisman, J. Pirenne, R. Porte   +14 more
semanticscholar   +1 more source

Inhibitors in Patients with Congenital Bleeding Disorders Other Than Hemophilia [PDF]

, 2017
The most worrying complication of replacement therapy for severe hemophilia A and B is currently the occurrence of inhibitory alloantibodies against infused factor VIII and factor IX, respectively.
Franchini, Massimo, Liumbruno, Giancarlo Maria, Marano, Giuseppe, Mengoli, Carlo, Piccinini, Vanessa, Pupella, Simonetta, Vaglio, Stefania   +6 more
core   +1 more source

Comparison of in‐Hospital Complication Rates After Transcatheter Aortic Valve Replacement in Patients With Bicuspid Versus Tricuspid Aortic Valves: A Retrospective Cohort Study

Catheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT Background Transcatheter aortic valve replacement (TAVR) has become a popular alternative to surgical aortic valve replacement (SAVR) for patients with valvular heart disease (VHD), particularly for those with aortic anomalies. Aims The study aimed to compare the risks of post‐TAVR complications between patients with bicuspid and tricuspid ...
Tingxi Zhu, Jiawei Luo, Xuan Huang, Lulu Liu, Kehan Li, Wei He, Xiaobo Zhou, Yingqiang Guo, Xiaoyan Yang   +8 more
wiley   +1 more source

Left Ventricular Apical Thrombus in Apical Hypertrophic Cardiomyopathy Without Aneurysm or Arrhythmia: A Case Report

Catheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT Apical hypertrophic cardiomyopathy (ApHCM) is a rare variant of hypertrophic cardiomyopathy, typically associated with a benign course. However, complications such as ventricular arrhythmias, apical aneurysms, and thrombus formation may occur. Left ventricular (LV) thrombus is an unusual finding in ApHCM, especially in patients with preserved ...
Ibrahim Antoun, Jeffrey Khoo, Sanjay S. Bhandari   +2 more
wiley   +1 more source

Histone H4 Promotes Prothrombin Autoactivation*

Journal of Biological Chemistry, 2013
Background: The molecular origin of the prothrombotic properties of histones is unknown. Results: Histone H4 interacts with prothrombin and promotes autoactivation. Conclusion: The prothrombotic properties of histone H4 are due to direct interaction with
Sergio Barranco-Medina, N. Pozzi, Austin D. Vogt, E. Di Cera   +3 more
semanticscholar   +1 more source

Quantitative Model‐Informed Dose Selection for a Milvexian Phase III Study in Patients With Atrial Fibrillation

Clinical Pharmacology &Therapeutics, EarlyView.
Milvexian, an activated factor XI inhibitor, is being evaluated in the LIBREXIA phase III program for the prevention of thrombotic events, including in patients with atrial fibrillation (LIBREXIA AF). To guide the selection of a phase III dose regimen for LIBREXIA AF, two main approaches were used: (1) population pharmacokinetics and exposure–response ...
Wangda Zhou, Emily Bozenhardt, Gregory E. Alexander, Matthew L. Zierhut, Samira Merali, Antoinette Ajavon‐Hartmann, Peter Zannikos, Hyunmoon Back, EunYoung Suh, Navin Goyal, Mahesh N. Samtani, Alexei N. Plotnikov, Chandni Valiathan   +12 more
wiley   +1 more source

Staphylococcal Superantigen-like Protein 10 (SSL10) Inhibits Blood Coagulation by Binding to Prothrombin and Factor Xa via Their γ-Carboxyglutamic Acid (Gla) Domain*

Journal of Biological Chemistry, 2013
Background: Staphylococcal superantigen-like proteins (SSLs) share structural similarity with superantigens but no superantigenic activity. Their functions remained unclear. Results: SSL10 binds to prothrombin and factor Xa via the γ-carboxyglutamic acid
S. Itoh, Ryosuke Yokoyama, G. Kamoshida, T. Fujiwara, H. Okada, T. Takii, T. Tsuji, S. Fujii, H. Hashizume, K. Onozaki   +9 more
semanticscholar   +1 more source

Quantitative Systems Toxicology Predicts Ivacaftor‐Induced Oxidative Stress Contributes to CFTR Modulator Hepatotoxicity

Clinical Pharmacology &Therapeutics, EarlyView.
Cystic fibrosis (CF) is a chronic hereditary disease that affects tens of thousands of people worldwide. The introduction of CFTR modulator therapies such as elexacaftor/tezacaftor/ivacaftor (ETI) has significantly improved the quality of life of people with CF.
Alan Shi, Cole Cornwell, Kyunghee Yang, Paul M. Beringer   +3 more
wiley   +1 more source