Results 41 to 50 of about 219,018 (388)

Canine reference intervals for coagulation markers using the STA Satellite and the STA-R Evolution analyzers [PDF]

, 2010
The aim of the current study was to determine canine reference intervals for prothrombin time (PT), activated partial thromboplastin time (APTT), fibrinogen, and antithrombin (AT) according to international recommendations. The STA Satellite coefficients
Braun, Jean-Pierre, Geffré, Anne, Grollier, Sophie, Hanot, Camille, Trumel, Catherine, Vergez, François   +5 more
core   +1 more source

Association of Factor V Leiden and Prothrombin G20210A Polymorphisms in Women with Recurrent Pregnancy Loss in Isfahan Province, Iran

International Journal of Preventive Medicine, 2018
Background: Maternal thrombophilia has been identified as a risk factor for recurrent pregnancy loss (RPL). The aim of this study was to investigate the association between prothrombin G20210A and factor V Leiden (FVL) polymorphisms in women with RPL and
Mohammad Taghi Kardi, Elham Yousefian, Azra Allahveisi, Sanaz Alaee   +3 more
doaj   +1 more source

Prothrombin Complex Concentrates for Perioperative Vitamin K Antagonist and Non–vitamin K Anticoagulant Reversal

Anesthesiology, 2018
Vitamin K antagonist therapy is associated with an increased bleeding risk, and clinicians often reverse anticoagulation in patients who require emergency surgical procedures.
J. Levy, J. Douketis, T. Steiner, J. Goldstein, T. Milling   +4 more
semanticscholar   +1 more source

Current perspective of venous thrombosis in the upper\ud extremity [PDF]

, 2008
Venous thrombosis of the upper extremity is a rare disease. Therefore, not as much is known about risk factors, treatment and the risk of recurrence as for venous thrombosis of the leg.
Doggen, C.J.M., Flinterman, L.E., Meer, F.J.M. van der, Rosendaal, F.R.   +3 more
core   +3 more sources

Structure of prothrombin in the closed form reveals new details on the mechanism of activation

Scientific Reports, 2018
The clotting factor prothrombin exists in equilibrium between closed and open conformations, but the physiological role of these forms remains unclear.
Mathivanan Chinnaraj, Zhiwei Chen, L. Pelc, Z. Grese, D. Bystranowska, E. Di Cera, N. Pozzi   +6 more
semanticscholar   +1 more source

Synthesis of Phospholipid-Protein Conjugates as New Antigens for Autoimmune Antibodies

Molecules, 2015
Copper(I)-catalyzed azide-alkyne cycloaddition, or CuAAC click chemistry, is an efficient method for bioconjugation aiming at chemical and biological applications.
Arindam Maity, Claudia Macaubas, Elizabeth Mellins, Kira Astakhova   +3 more
doaj   +1 more source

Cryo‐EM structures of coagulation factors

Research and Practice in Thrombosis and Haemostasis, 2022
A State of the Art lecture titled “Cryo‐EM structures of coagulation factors” was presented at the ISTH Congress in 2022. Cryogenic electron microscopy (cryo‐EM) is a revolutionary technique capable of solving the structure of high molecular weight ...
Enrico Di Cera, Bassem M. Mohammed, Leslie A. Pelc, Bosko M. Stojanovski   +3 more
doaj   +1 more source

Multivariate Analysis of Protein–Nanoparticle Binding Data Reveals a Selective Effect of Nanoparticle Material on the Formation of Soft Corona

Nanomaterials, 2023
When nanoparticles are introduced into the bloodstream, plasma proteins accumulate at their surface, forming a protein corona. This corona affects the properties of intravenously administered nanomedicines.
Susannah Emily Cornwell, Sarah Ogechukwu Okocha, Enrico Ferrari   +2 more
doaj   +1 more source

Decreased prothrombin conversion and reduced thrombin inactivation explain rebalanced thrombin generation in liver cirrhosis

PLoS ONE, 2017
Impaired coagulation factor synthesis in cirrhosis causes a reduction of most pro- and anticoagulant factors. Cirrhosis patients show no clear bleeding or thrombotic phenotype, although they are at risk for both types of hemostatic event.
R. Kremers, Marie-Claire F. Kleinegris, M. Ninivaggi, B. de Laat, H. ten Cate, G. Koek, R. Wagenvoord, H. Hemker   +7 more
semanticscholar   +1 more source

Liver resection or combined chemoembolization and radiofrequency ablation improve survival in patients with hepatocellular carcinoma [PDF]

, 2007
Background/ Aims: To evaluate the long-term outcome of surgical and non-surgical local treatments of patients with hepatocellular carcinoma (HCC). Methods: We stratified a cohort of 278 HCC patients using six independent predictors of survival according ...
Angelika Schrader, Bloomston M, Bosch FX, Burkhard Göke, Castells A, Christian Graeb, Christoph Jüngst, Curley SA, Dieter Jüngst, Florian Löhe, Franco D, Goldberg SN, Gundula Straub, Horst-Günter Rau, Karl-Walter Jauch, Kotoh K, Livraghi T, Livraghi T, Livraghi T, Maximilian Reiser, Qian J, Ralf-Thorsten Hoffmann, Rolf Schauer, Rossi S, Rossi S, Ryder SD, Sasaki Y, Selin Dogan, Takenaka K, Thomas Helmberger, Tobias Jakobs, Tobias Waggershauser, Wolfgang H. Caselmann   +32 more
core   +1 more source