Genetic variants underlying precancerous conditions of hepatocellular carcinoma
International Journal of Cancer, EarlyView.Abstract Hepatocellular carcinoma (HCC) is the most common form of liver cancer, accounting for 80% of cases worldwide. While chronic hepatitis B and C infections remain primary risk factors, emerging evidence highlights the increasing contributions of metabolic dysfunction‐associated steatotic liver disease (MASLD) and alcohol‐associated liver disease
Jonathan Jaime G. Guerrero +7 more
wiley +1 more source
OBSERVATIONS ON THE PLASMA PROTHROMBIN AND THE EFFECTS OF VITAMIN K IN PATIENTS WITH LIVER OR BILIARY TRACT DISEASE 1 [PDF]
, 1940 Frederick J. Pohle, John K. Stewart
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Clinical review: Prothrombin complex concentrates - evaluation of safety and thrombogenicity
Critical Care, 2011 Prothrombin complex concentrates (PCCs) are used mainly for emergency reversal of vitamin K antagonist therapy. Historically, the major drawback with PCCs has been the risk of thrombotic complications.
B. Sørensen +4 more
semanticscholar +1 more source
Evaluation of coagulation disorders and iron deficiency in women with heavy menstrual bleeding
International Journal of Gynecology &Obstetrics, EarlyView.Abstract Objective To explore the incidence of congenital bleeding disorders (CBD), which may result in anemia, in a large cohort of women referred for heavy menstrual bleeding (HMB) in a specialized gynecologic unit. Methods Between January 2022 and January 2024, all women referred for HMB were screened.
Lucia Rugeri +8 more
wiley +1 more source
II. HEMORRHAGIC DISEASE. ANTITHROMBIN AND PROTHROMBIN FACTORS [PDF]
, 1913 G. H. Whipple
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Journal of Biophotonics, EarlyView.The broadband absorption coefficient spectrum of the rabbit lung was reconstructed from the absorption spectra of tissue components. The similar accumulation of melanin and lipofuscin was retrieved from the broadband baseline in the absorption coefficient spectrum, and the calculation of the absorption fold ratios for proteins, DNA and hemoglobin ...
Maria R. Pinheiro +2 more
wiley +1 more source
PROTHROMBIN DEFICIENCY AND THE BLEEDING TENDENCY IN LIVER INJURY (CHLOROFORM INTOXICATION) [PDF]
, 1937 H. P. Smith +2 more
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Effects of Hepatic or Renal Impairment on Pharmacokinetics of Fruquintinib
The Journal of Clinical Pharmacology, EarlyView.Abstract Fruquintinib (FRUZAQLATM) is a highly selective tyrosine kinase inhibitor of all three vascular endothelial growth factor receptors (‐1, ‐2, and ‐3). Two Phase 1, open‐label, single‐dose studies investigated the impact of hepatic or renal impairment on the pharmacokinetics and tolerability of fruquintinib.
Martha Gonzalez +8 more
wiley +1 more source
Pharmacokinetics and Safety of Fezolinetant in Women with Hepatic or Renal Impairment
The Journal of Clinical Pharmacology, EarlyView.Abstract The neurokinin 3 receptor antagonist fezolinetant is an approved treatment for vasomotor symptoms due to menopause. The impacts of hepatic and renal impairment on the pharmacokinetics and safety of a single oral dose of fezolinetant 30 mg were investigated in two independent studies.
Megumi Iwai +8 more
wiley +1 more source
A FACTOR IN SERUM WHICH ACCELERATES THE CONVERSION OF PROTHROMBIN TO THROMBIN: I. ITS DETERMINATION AND SOME PHYSIOLOGIC AND BIOCHEMICAL PROPERTIES [PDF]
, 1949 André de Vries +4 more
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