Results 71 to 80 of about 219,018 (388)

An Aptamer‐Based EXACT Anticoagulant as a Sustainable, Animal‐Free Alternative to Unfractionated Heparin

Advanced Science, EarlyView.
By simply conjugating thrombin's active‐site inhibitor, dabigatran, with an exosite inhibitor, aptamer HD1, the resulting EXosite‐ACTive site (EXACT) inhibitors show two orders of magnitude higher potency and selectivity via synergistic binding, while maintaining the aptamer's antidote‐reversible trait, yielding a potential substitute for the animal ...
Haixiang Yu, George Pitoc, Manqi Zhang, Jeffrey Clancy, James Frederiksen, Amy Yan, Samuel Francis, Rebecca Sullenger, Rachel Rempel, Susannah Gammell, Jillian Caiazzi, Bruce A. Sullenger   +11 more
wiley   +1 more source

Cell proliferation and oncogene expression after bile duct ligation in the rat: Evidence of a specific growth effect on bile duct cells [PDF]

, 1995
The proliferative response of the rat liver was measured after temporary or permanent total biliary obstruction (BDO) and in different regions after selective ligation of the lobar ducts draining the right 60% of the hepatic mass.
Azzarone, A, Bouzahzah, B, Carr, B, Francavilla, A, Panella, C, Polimeno, L, Starzl, TE, Subbotin, V, Zeng, QH   +8 more
core   +1 more source

Determination of Prothrombin

Experimental Biology and Medicine, 1939
The author1 developed a quantitative method for the determination of prothrombin based on the principle that the clotting time of blood or plasma is a quantitative measure of the prothrombin concentration provided an excess of thrombin and a constant concentration of calcium are present. For convenience and accuracy, the blood is oxa-lated and the test
openaire   +3 more sources

NQO1/p65/CXCL12 Axis‐Recruited Tregs Mediate Resistance to Anti‐PD‐1 Plus Lenvatinib Therapy in PIVKA‐II‐Positive Hepatocellular Carcinoma

Advanced Science, EarlyView.
High PIVKA‐II expression in HCC correlates with resistance to anti‐PD‐1 plus lenvatinib, driven by an immunosuppressive TME. NQO1/p65/CXCL12 axis recruits Tregs to promote resistance to anti‐PD‐1 plus lenvatinib in HCC with high PIVKA‐II expression.
Biao Gao, Yafei Wang, Zhuoya Sun, Haowen Tang, Yinbiao Cao, Hao Jiang, Wenwen Zhang, Yinzhe Xu, Bingyang Hu, Zhe Liu, Guankun Mao, Xuerui Li, Junfeng Li, Tao Wan, Bing Liu, Xiao Zhao, Shunchang Jiao, Chonghui Li, Shichun Lu   +18 more
wiley   +1 more source

Guidelines on fibrinogen assays [PDF]

, 2003
No abstract ...
Becker, Blanco, Blomback, Cambas, Chantarangkul, Chantarangkul, Chitolie, Chitolie, Clauss, Cremer, Cushman, De Cristofaro, De Maat, De Metz, Eliasson, Gaffney, Gordon D. O. Lowe, Hantgan, Haverkate, Hoffmann, Humphries, Ian J. Mackie, Jacobsson, Kitchen, Kluft, Lawrie, Lowe, Lowe, Ludlam, Machin, Mackie, Marder, MDA, MDA, Natelson, NCCLS, Nieuwenhuizen, Oosting, Palareti, Rampling, Ratnoff, Rosenson, Rossi, Samuel J. Machin, Steven Kitchen, Swain, Sweetnam, Sweetnam, Thompson, Van Der Bom, Vermylen, Whicher, World Health Organisation Report   +52 more
core   +1 more source

Ultrafine Molybdenum Wire Braided Neurointerventional Implants: Bridging Biodegradability and Neurovascular Safety for Stroke Treatment

Advanced Science, EarlyView.
Molybdenum (Mo), with its unique strength, uniform corrosion, and radiopacity, enables innovative biodegradable implants for transformative stroke therapy. Abstract Neurovascular implants for stroke intervention face a critical dilemma: permanent devices (e.g., nitinol stents, platinum coils) often trigger chronic inflammation and recurrence, whereas ...
Yunong Shen, Yiming Huang, Yang Zhang, Chunhao Yu, Hanqi Liu, Dong Bian, Di Wu, Wu Wang, Xunming Ji, Yufeng Zheng, Miaowen Jiang, Ming Li   +11 more
wiley   +1 more source

Des-γ-Carboxy Prothrombin (DCP) as a Potential Autologous Growth Factor for the Development of Hepatocellular Carcinoma

Cellular Physiology and Biochemistry, 2014
Des-γ-carboxy prothrombin (DCP) is a prothrombin precursor produced in hepatocellular carcinoma (HCC). Because of deficiency of vitamin K or γ-glutamyl carboxylase in HCC cells, the 10 glutamic acid (Glu) residues in prothrombin precursor did not ...
Yu-sheng Zhang, Jia-Hui Chu, S. Cui, Zhi-yu Song, Xian-Jun Qu   +4 more
semanticscholar   +1 more source

PURIFICATION AND CHARACTERIZATION OF A VARIANT OF HUMAN PROTHROMBIN: PROTHROMBIN SEGOVIA [PDF]

Thrombosis Research, 1997
A dysprothrombin designated prothrombin Segovia was isolated from the plasma of an individual with normal prothrombin antigen and prothrombin activity lesser than 25% of the control prothrombin activity. Activation by prothrombinase complex showed a lower amidolytic than clotting activity, which suggests a lesser generation of active intermediates than
Ramón Montes, José A. Páramo, Luis F Montaño, M. Collados, Javier Fernández, Eduardo Rocha, José R. Borbolla   +6 more
openaire   +3 more sources

Novel Bioresorbable Bone Wax for Potentiated Hemostasis and Osteogenesis

Advanced Science, EarlyView.
The synthesized bioresorbable bone wax material for hemostasis and osteogenesis. The preparation process of the novel resorbable bone wax and its mechanism of accelerating coagulation and promoting osteoregeneration through blood cell aggregation. Abstract Orthopedic surgery faces dual challenges of uncontrolled bleeding and poor bone regeneration at ...
Longbao, Yanbin, Pengyu Fu, Shaojun Li, Pengning She, Yang xiao, Jiaming Ye, Wanqi Li, Shaochuan Li, Wei Xue, Rui Guo   +10 more
wiley   +1 more source

Homozygous prothrombin gene mutation and ischemic cerebrovascular disease: A case report and review of literature

Journal of Applied Hematology, 2019
This report describes a 32-year-old Saudi nonsmoker man who presented to the emergency department with a history of left-sided hemiparesis and no risk factors for cerebral stroke being reported, except type II diabetes mellitus.
Mohammed AlSheef, Mohammed S Almohaya, Arshad M Mian, Saad Mohammed Aljuhayyim   +3 more
doaj   +1 more source