Results 1 to 10 of about 98,105 (127)

Prevalence of c-myc expression in breast lesions associated with microcalcifications detected by routine mammography [PDF]

São Paulo Medical Journal, 2009
CONTEXT AND OBJECTIVE: Genetic abnormalities in cell proliferation-regulating genes have been described in premalignant lesions. The aims here were to evaluate c-myc protein expression in non-palpable breast lesions associated with microcalcifications ...
Renato Coimbra Mazzini, Simone Elias, Afonso Celso Pinto Nazário, Cláudio Kemp, Ângela Flávia Logullo   +4 more
doaj   +3 more sources

CEMIP promotes gefitinib resistance in lung cancer with EGFR-mutation possibly through forming a stable complex CEMIP/c-MYC [PDF]

BBA Advances
While gefitinib greatly improves the prognosis of lung cancer patients with epidermal growth factor receptor (EGFR) mutation, its inevitable resistance severely diminishes therapeutic efficacy.
Li Li, Jiaxiu Xie, Jinxing Liang, Hua Su, Xiaoju Shen, Xiaoxiang Mo, Xinli Lin, Weidan Tan, Kun Wu, Fucui Zhu, Li Wang, Ying Liu   +11 more
doaj   +2 more sources

Hinge like domain motion facilitates human RBMS1 protein binding to proto-oncogene c-myc promoter [PDF]

Nucleic Acids Research, 2021
Abstract DNA binding proteins recognize DNA specifically or non-specifically using direct and indirect readout mechanisms like sliding, hopping, and diffusion. However, a common difficulty in explicitly elucidating any particular mechanism of site-specific DNA-protein recognition is the lack of knowledge regarding target sequences and ...
Priyanka Aggarwal, Neel Sarovar Bhavesh
openaire   +2 more sources

Polydatin Inhibits Cell Viability, Migration, and Invasion Through Suppressing the c-Myc Expression in Human Cervical Cancer

Frontiers in Cell and Developmental Biology, 2021
Polydatin, an active ingredient from the roots of Polygonum cuspidatum, is considered to have protective effects on the cardiovascular system and liver.
Longchang Bai, Longchang Bai, Longchang Bai, Yingkang Ma, Yingkang Ma, Yingkang Ma, Xue Wang, Qiongni Feng, Qiongni Feng, Zhining Zhang, Zhining Zhang, Zhining Zhang, Sijie Wang, Sijie Wang, Sijie Wang, Huijie Zhang, Huijie Zhang, Huijie Zhang, Xinyu Lu, Xinyu Lu, Xinyu Lu, Yonghui Xu, Erhu Zhao, Erhu Zhao, Erhu Zhao, Hongjuan Cui, Hongjuan Cui, Hongjuan Cui, Hongjuan Cui   +28 more
doaj   +1 more source

Transcriptional activation of c-myc proto-oncogene by WT1 protein [PDF]

Oncogene, 2004
The Wilms' tumor 1 gene (WT1) plays an essential role in urogenital development and malignancy. Through DNA binding, WT1 can either enhance or repress transcription depending on the context of the DNA-binding sites or the cell type in which it is expressed.
Youqi, Han, Serban, San-Marina, Jian, Liu, Mark D, Minden   +3 more
openaire   +2 more sources

The protein encoded by the human proto-oncogene c-myc. [PDF]

Proceedings of the National Academy of Sciences, 1984
The proto-oncogene c-myc may play a role in controlling the growth and division of normal cells, and abnormalities of the gene have been implicated in the genesis of a substantial variety of human tumors. To facilitate further study of these issues, we developed antisera that permit the identification and isolation of the protein encoded by the human ...
G, Ramsay, G I, Evan, J M, Bishop
openaire   +2 more sources

MYC regulates metabolism through vesicular transfer of glycolytic kinases

Open Biology, 2021
Amplification of the proto-oncogene MYCN is a key molecular aberration in high-risk neuroblastoma and predictive of poor outcome in this childhood malignancy. We investigated the role of MYCN in regulating the protein cargo of extracellular vesicles (EVs)
Alexia Tsakaneli, Victor Corasolla Carregari, Martina Morini, Alessandra Eva, Giuliana Cangemi, Olesya Chayka, Evgeny Makarov, Sandra Bibbò, Emily Capone, Gianluca Sala, Vincenzo De Laurenzi, Evon Poon, Louis Chesler, Luisa Pieroni, Martin R. Larsen, Giuseppe Palmisano, Arturo Sala   +16 more
doaj   +1 more source

c-Myc is essential to prevent endothelial pro-inflammatory senescent phenotype. [PDF]

PLoS ONE, 2013
The proto-oncogene c-Myc is vital for vascular development and promotes tumor angiogenesis, but the mechanisms by which it controls blood vessel growth remain unclear. In the present work we investigated the effects of c-Myc knockdown in endothelial cell
Victoria Florea, Nithya Bhagavatula, Gordana Simovic, Francisco Y Macedo, Ricardo A Fock, Claudia O Rodrigues   +5 more
doaj   +1 more source

High Intrinsic Oncogenic Potential in the Myc-Box-Deficient Hydra Myc3 Protein

Cells, 2023
The proto-oncogene myc has been intensively studied primarily in vertebrate cell culture systems. Myc transcription factors control fundamental cellular processes such as cell proliferation, cell cycle control and stem cell maintenance.
Marion Lechable, Xuechen Tang, Stefan Siebert, Angelika Feldbacher, Monica L. Fernández-Quintero, Kathrin Breuker, Celina E. Juliano, Klaus R. Liedl, Bert Hobmayer, Markus Hartl   +9 more
doaj   +1 more source

Antiproliferative protein Tob directly regulates c-myc proto-oncogene expression through cytoplasmic polyadenylation element-binding protein CPEB [PDF]

Oncogene, 2012
The regulation of mRNA deadenylation constitutes a pivotal mechanism of the post-transcriptional control of gene expression. Here we show that the antiproliferative protein Tob, a component of the Caf1-Ccr4 deadenylase complex, is involved in regulating the expression of the proto-oncogene c-myc.
K, Ogami, N, Hosoda, Y, Funakoshi, S, Hoshino   +3 more
openaire   +2 more sources