Results 31 to 40 of about 5,052 (178)
Progress in synthesizing protocells [PDF]
Experimental Biology and Medicine, 2018 The traditional route to investigating biology by perturbing living systems or by individually purifying and characterizing component parts is giving way to more complex endeavors where chemists and physicists attempt to build cells from scratch. Parallel efforts are underway that either exploits extant biological parts or prebiotically plausible ...
Toparlak, Omer Duhan, Mansy, Sheref S.
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A Synthetic Protocell‐Based Heparin Scavenger [PDF]
Small, 2022 AbstractHeparin is a commonly applied blood anticoagulant agent in clinical use. After treatment, excess heparin needs to be removed to circumvent side effects and recover the blood‐clotting cascade. Most existing heparin antidotes rely on direct heparin binding and complexation, yet selective compartmentalization and sequestration of heparin would be ...
Yang, Shuo +6 more
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Effect of migration in a diffusion model for template coexistence in protocells [PDF]
, 2014 The compartmentalization of distinct templates in protocells and the exchange of templates between them (migration) are key elements of a modern scenario for prebiotic evolution.
Fontanari, Jose F., Serva, Maurizio
core +2 more sources
, 2021 I provide two arguments against value-free naturalism. Both are based on considerations concerning biological teleology. Value-free naturalism is the thesis that both (1) everything is, at least in principle, under the purview of the sciences and (2) all
A Wouters +34 more
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Angewandte Chemie, EarlyView.This study explores the origins of life by linking prebiotic chemistry, the emergence of information‐carrying molecules such as RNA and proteins, and philosophical questions about consciousness. The study emphasizes the role of molecular evolution in the Central Dogma and provides insights into the chemical origins of biology and the basis of life's ...
Harald Schwalbe +5 more
wiley +2 more sources
Recent progress in primitive polyester synthesis and membraneless microdroplet assembly
Biophysics and Physicobiology, 2023 While it is often believed that the origins of life required participation of early biomolecules, it has been recently proposed that “non-biomolecules”, which would have been just as, if not more, abundant on early Earth, could have played a part.
Tony Z. Jia, Kuhan Chandru
doaj +1 more source
Advanced Materials Interfaces, 2023 Neuroblastoma cells can acquire resistance mechanisms that make them invulnerable to chemotherapeutic agents. The use of nanoparticles as drug carriers provides the possibility to deliver several drugs simultaneously to specific tumoral cell populations,
Jorge Parra‐Nieto +8 more
doaj +1 more source
A model of protocell based on the introduction of a semi-permeable membrane in a stochastic model of catalytic reaction networks [PDF]
, 2013 In this work we introduce some preliminary analyses on the role of a semi-permeable membrane in the dynamics of a stochastic model of catalytic reaction sets (CRSs) of molecules. The results of the simulations performed on ensembles of randomly generated
Damiani, Chiara +4 more
core +3 more sources
Protocells and RNA Self-Replication [PDF]
Cold Spring Harbor Perspectives in Biology, 2018 The general notion of an "RNA world" is that, in the early development of life on the Earth, genetic continuity was assured by the replication of RNA, and RNA molecules were the chief agents of catalytic function. Assuming that all of the components of RNA were available in some prebiotic locale, these components could have assembled into activated ...
Gerald F. Joyce, Jack W. Szostak
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SYNCHRONIZATION PHENOMENA IN PROTOCELL MODELS [PDF]
BIOMAT 2007, 2008 This work aims to consider simplified models of protocells in order to describe their general behaviors. The advantage of the modelling approach is that the early protocells of life-forms on Earth are not reproduced in the present time. However, the problem is considered as a right track to understand the origin of life as well as to work with more ...
FILISETTI, alessandro +4 more
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