Results 61 to 70 of about 5,052 (178)

Synthesis of a π‐Extended Phenazine Diimide Derivative and Characterization of Its Closed‐Shell Reduced States

Chemistry – A European Journal, EarlyView.
In this work, the synthesis and characterization of novel π‐extended phenazine diimides is reported. The derivatives undergo differential reduction to a dihydrophenazine or Meisenheimer form depending on the reaction conditions employed. The outcome of this work highlights the paramount importance of structural design in determining the nature of the ...
Francesco Rigodanza, Beatrice Bartolomei, Ilaria Crea, Paolo Costa, Nicola Demitri, Marcella Bonchio, Maurizio Prato, Jacopo Dosso   +7 more
wiley   +1 more source

Construction of membrane-bound artificial cells using microfluidics: a new frontier in bottom-up synthetic biology [PDF]

, 2016
The quest to construct artificial cells from the bottom-up using simple building blocks has received much attention over recent decades and is one of the grand challenges in synthetic biology.
Elani, Y
core   +2 more sources

Solvent‐Mediated Dewetting Principles for Cell‐Sized Liposome Formation

Small, EarlyView.
Dynamics of solvent‐mediated dewetting for giant unilamellar liposome formation. Solvent removal, through changing lipid packing and membrane tension, is shown to induce partial dewetting into equilibrium low and high budding angle morphologies. Complete dewetting requires mechanical force, quantified using optical tweezers.
Mostafa Bakouei, Tatiana Avsievich, Indraja Sundara Raju, David Stumpf, Ali Kalantarifard, Benny Ryplida, Caglar Elbuken   +6 more
wiley   +1 more source

Putative roles of terpenoids in primitive membranes

Frontiers in Ecology and Evolution, 2023
For the continuation and evolution of life, primitive membranes formed from prebiotically available components must have fulfilled certain essential requirements. Candidate amphiphiles, such as straight-chain fatty acids, that can self-assemble into cell-
Joshua P. King, Joshua P. King, Anna Wang, Anna Wang   +3 more
doaj   +1 more source

Protocell design through modular compartmentalization [PDF]

Journal of The Royal Society Interface, 2013
De novo synthetic biological design has the potential to significantly impact upon applications such as energy generation and nanofabrication. Current designs for constructing organisms from component parts are typically limited in scope, as they utilize a cut-and-paste ideology to create simple stepwise engineered protein-signalling pathways.
Miller, David, Booth, Paula J, Seddon, John M, Templer, Richard H, Law, Robert V, Woscholski, Rudiger, Ces, Oscar, Barter, Laura M C   +7 more
openaire   +3 more sources

Fast and Slow Signal Propagation in Abiotic Polypeptide Assemblies

ChemBioChem, Volume 27, Issue 6, 27 March 2026.
Proteinoid microspheres formed by thermal polymerization of amino acids exhibit spontaneous electrical potential fluctuations without genetic material, membranes, or ion channels. Multi‐electrode recordings and electron microscopy reveal composition‐dependent voltage oscillations, long‐term drifts, and correlated signals across electrodes.
Panagiotis Mougkogiannis, Andrew Adamatzky   +1 more
wiley   +1 more source

Protocells Either Synchronize or Starve. [PDF]

Entropy (Basel)
Two different processes take place in self-reproducing protocells, i.e., (i) cell reproduction by fission and (ii) duplication of the genetic material. One major problem is indeed that of assuring that the two processes take place at the same pace, i.e., that they synchronize, which is a necessary condition for sustainable growth.
Villani M, Serra R.
europepmc   +5 more sources

Biomimetic Construction of Abiotic Membranes Through Acylation of Cationic Diamino Acids

ChemBioChem, Volume 27, Issue 6, 27 March 2026.
Cells produce membrane‐forming phospholipids through complex enzymatic pathways. Here, we present the in situ synthesis of a novel class of abiotic phospholipid analogs (APAs) featuring a permanent choline‐mimetic cation on diamino acid backbones.
Federica A. Souto‐Trinei, Bruno Delgado Gonzalez, Roberto J. Brea   +2 more
wiley   +1 more source

Growth, Dissolution and Segregation of Genetically Encoded RNA Droplets by Ribozyme Catalysis

Angewandte Chemie, Volume 138, Issue 7, 9 February 2026.
Ribozymes enable sequence‐encoded turnover of RNA droplet material, resulting in transiently active droplets that selectively segregate based on their genotype. This establishes a direct link between genetic information and droplet behavior, marking a step toward programmable, evolvable RNA‐based compartments with life‐like properties.
Franziska Giessler, William Verstraeten, Tobias Abele, Stefan J. Maurer, Luca Monari, Kerstin Göpfrich   +5 more
wiley   +2 more sources

The reproduction process of Gram-positive protocells

Scientific Reports
Protocells are believed to have existed on early Earth prior to the emergence of prokaryotes. Due to their rudimentary nature, it is widely accepted that these protocells lacked intracellular mechanisms to regulate their reproduction, thereby relying ...
Dheeraj Kanaparthi, Marko Lampe, Jan-Hagen Krohn, Baoli Zhu, Falk Hildebrand, Thomas Boesen, Andreas Klingl, Prasad Phapale, Tillmann Lueders   +8 more
doaj   +1 more source