Results 61 to 70 of about 6,958 (184)

An emerging role of the cellular prion protein as a modulator of a morphogenetic program underlying epithelial-to-mesenchymal transition

Frontiers in Cell and Developmental Biology, 2014
Knowledge of phenotypic changes the cellular prion protein (PrPC) contributes to may provide novel avenues for understanding its function. Here we consider data from functional knockout/down studies and protein-protein interaction analyses from the ...
Mohadeseh eMehrabian, Sepehr eEhsani, Gerold eSchmitt-Ulms   +2 more
doaj   +1 more source

Advice on animal and public health risks of insects reared on former foodstuffs as raw material for animal feed

Food Risk Assess Europe, Volume 4, Issue 1, January 2026.
Abstract In the coming decades, there is expected to be a sharply increased demand for dietary proteins for humans and animals. As a result, there is an increasing focus on reared insects as a new source of protein. According to the Ministry of Agriculture, Nature and Food Quality (LNV), the use of food chain residual flows such as former foodstuffs as
L.F.F. Kox, D.T.H.M. Sijm
wiley   +1 more source

Neuron-Derived Exosome Proteins May Contribute to Progression From Repetitive Mild Traumatic Brain Injuries to Chronic Traumatic Encephalopathy

Frontiers in Neuroscience, 2019
The recent recognition that Alzheimer disease-like pathology may be found in chronic traumatic encephalopathy (CTE) even after acute mild traumatic brain injury (mTBI) has increased the urgency of elucidating mechanisms, identifying biomarkers predictive
Edward J. Goetzl, Aurélie Ledreux, Ann-Charlotte Granholm, Fanny M. Elahi, Laura Goetzl, Jade Hiramoto, Dimitrios Kapogiannis   +6 more
doaj   +1 more source

Characteristic distribution and molecular properties of normal cellular prion protein in human endocrine and exocrine tissues

Scientific Reports, 2022
Prion disease is an infectious and fatal neurodegenerative disease. Human prion disease autopsy studies have revealed abnormal prion protein (PrPSc) deposits in the central nervous system and systemic organs.
Sachiko Koyama, Hideko Noguchi, Kaoru Yagita, Hideomi Hamasaki, Masahiro Shijo, Motoi Yoshimura, Kohei Inoshita, Naokazu Sasagasako, Hiroyuki Honda   +8 more
doaj   +1 more source

The Cellular Prion Protein PrPc Is Expressed in Human Enterocytes in Cell-Cell Junctional Domains [PDF]

Journal of Biological Chemistry, 2004
The physiological function of PrPc, the cellular isoform of prion protein, still remains unclear, although it has been established, in vitro or by using nerve cells, that it can homodimerize, bind copper, or interact with other proteins. Expression of PrPc was demonstrated as necessary for prion infection propagation.
Etienne, Morel, Stephane, Fouquet, Danielle, Chateau, Lucile, Yvernault, Yveline, Frobert, Martine, Pincon-Raymond, Jean, Chambaz, Thierry, Pillot, Monique, Rousset   +8 more
openaire   +2 more sources

Prodromal Sleep Disturbances and Polysomnographic Findings in Patients With Creutzfeldt–Jakob Disease

Brain and Behavior, Volume 15, Issue 12, December 2025.
This study investigates the sleep‐related manifestations of Creutzfeldt–Jakob disease (CJD) by analyzing electroencephalography (EEG) and polysomnography (PSG) findings in a cohort of seven patients diagnosed between 2013 and 2023. Although only three patients initially reported sleep‐related complaints, comprehensive assessments revealed that all ...
Ezgi Demirel, Gul Yalcin‐Cakmakli, Ezgi Yetim, Serap Saygi, Fadime Irsel Tezer   +4 more
wiley   +1 more source

Pharmacological Agents Targeting the Cellular Prion Protein

Pathogens, 2018
Prion diseases are associated with the conversion of the cellular prion protein (PrPC), a glycoprotein expressed at the surface of a wide variety of cell types, into a misfolded conformer (the scrapie form of PrP, or PrPSc) that accumulates in brain ...
Maria Letizia Barreca, Nunzio Iraci, Silvia Biggi, Violetta Cecchetti, Emiliano Biasini   +4 more
doaj   +1 more source

Amyloid Beta in Alzheimer's Disease: Mechanisms, Biomarker Potential, and Therapeutic Targets

CNS Neuroscience &Therapeutics, Volume 31, Issue 12, December 2025.
The limited clinical efficacy of anti‐Aβ antibodies has challenged the Aβ hypothesis, compelling the integration of key mechanisms—including neuroinflammation, mitochondrial dysfunction, oxidative stress, and post‐translational modifications of Aβ—into a revised model of Alzheimer's disease.
Shamseddin Ahmadi, Shiler Khaledi, Kimia Ahmadi, Kambiz Hassanzadeh   +3 more
wiley   +1 more source

Characterization of cellular prion protein (PrPC) in Caenorhabditis elegans

, 2011
Cellular prion protein (PrPC) is a conserved glycoprotein predominantly expressed in neurons, glial and lymphatic cells. It is associated with the broad group of prion diseases in which PrPC becomes misfolded. However, the purpose of PrPC in living cells is still enigmatic.
openaire   +2 more sources

Impact of Hanks Kinase‐Dependent Phosphorylation of CodY on the Physiology and Virulence in Bacillus cereus

MicrobiologyOpen, Volume 14, Issue 6, December 2025.
CodY is a global regulator whose phosphorylation at serine 215 by PrkC/YbdM alters its DNA binding, thereby modulating gene expression and impacting motility, biofilm formation, cytotoxicity, and pathogenicity in Bacillus cereus, suggesting a conserved regulatory mechanism in Firmicutes ABSTRACT CodY acts as a key regulatory protein involved in ...
Mounia Kortebi, Céline Henry, Christophe Buisson, Christelle Lemy, Michel Gohar, Didier Lereclus, Ivan Mijakovic, Sandrine Poncet   +7 more
wiley   +1 more source