Results 71 to 80 of about 9,831 (166)

Less Invasive Sampling Methods for PRRSV Detection in Swine: Dry Blood Spots, Oral Swabs, and Tonsil Oral Scrubbing in Intentionally Exposed Gilts

Transboundary and Emerging Diseases, Volume 2026, Issue 1, 2026.
Serum collection from swine is invasive and labor‐intensive, which limits its practicality for disease surveillance and highlights the need for less invasive and cost‐effective alternatives. In this study, we evaluated the sensitivity of blood‐soaked filter papers (dry blood spots [DBS]), blood‐soaked swabs, oral swabs (OS), and tonsil oral scrubbing ...
Mariana Kikuti, Claudio Marcello Melini, Xiaomei Yue, Amanda Wzorek, Igor A. D. Paploski, Albert Rovira, Cesar A. Corzo, Nan-hua Chen   +7 more
wiley   +1 more source

Role of CD163 in PRRSV infection

Virology
Porcine reproductive and respiratory syndrome virus (PRRSV) is a highly infectious agent that poses a significant economic threat to the global swine industry. Efficient viral entry relies on interactions with cellular receptors, with CD163-a cysteine-rich scavenger receptor found on porcine alveolar macrophages (PAMs)-playing a critical role ...
Raymond R.R. Rowland, Alberto Brandariz-Nuñez   +1 more
openaire   +2 more sources

Phorbol Myristate Acetate Inhibits Senecavirus A Replication by Activating IKBKE–Mediated IFN Pathway and NF‐κB Signal

Transboundary and Emerging Diseases, Volume 2026, Issue 1, 2026.
Senecavirus A (SVA) is an emerging picornavirus causing vesicular disease indistinguishable from foot‐and‐mouth disease virus (FMDV). So far, there are no commercial vaccines and effective therapeutic drugs against SVA infection in China. Here, a library of 112 compounds were screened, and we found that phorbol myristate acetate plays an antagonistic ...
Junfang Yan, Yanni Gao, Chengyi Guo, Yubei Dong, Ping Jiang, Juan Bai, Linzhu Ren   +6 more
wiley   +1 more source

The Role of Short Journey Transportation in the Spreading of Swine Pathogens and Antimicrobial‐Resistant Bacteria

Transboundary and Emerging Diseases, Volume 2026, Issue 1, 2026.
The transport of live pigs poses a risk to on‐farm biosecurity. Trucks can carry pathogens with significant economic and health impacts, including antimicrobial‐resistant (AMR) bacteria. This study aimed to investigate the microbiological contamination of trucks before and after loading, focusing on AMR bacteria and other major pathogens transmissible ...
Marta Masserdotti, Nicoletta Formenti, Anna Donneschi, Flavia Guarneri, Federico Scali, Claudia Romeo, Enrico Giacomini, Cristina Bertasio, Maria Beatrice Boniotti, Giovanni Loris Alborali, Camilla Luzzago, Esha Saini   +11 more
wiley   +1 more source

Design of B‐Cell Multi‐Epitope Subunit Vaccines Against Glaesserella parasuis by Reverse Vaccinology: An In Silico and In Vivo Study

Transboundary and Emerging Diseases, Volume 2026, Issue 1, 2026.
Glässer’s disease caused by Glaesserella parasuis (GPS) is a severe disease that results in substantial economic losses to the swine industry worldwide. Here we describe a multiepitope vaccine cocktail (MEVC) that was designed using reverse vaccinology and immunoinformatics. The MEVC was comprised of three multiepitope subunits (MESs, designated as TB,
Yan Gong, Na Li, Ziheng Li, He Wang, Di Zhang, Hong Chu, Zhichao Lu, Aiqing Jia, Fengyang Li, Liancheng Lei, Zhong Peng   +10 more
wiley   +1 more source

Establishment of Systems to Enable Isolation of Porcine Monoclonal Antibodies Broadly Neutralizing the Porcine Reproductive and Respiratory Syndrome Virus

Frontiers in Immunology, 2019
The rapid evolution of porcine reproductive and respiratory syndrome viruses (PRRSV) poses a major challenge to effective disease control since available vaccines show variable efficacy against divergent strains.
David Goldeck, Dana M. Perry, Dana M. Perry, Jack W. P. Hayes, Jack W. P. Hayes, Luke P. M. Johnson, Luke P. M. Johnson, Jordan E. Young, Parimal Roychoudhury, Parimal Roychoudhury, Elle L. McLuskey, Elle L. McLuskey, Katy Moffat, Arjen Q. Bakker, Mark J. Kwakkenbos, Jean-Pierre Frossard, Raymond R. R. Rowland, Michael P. Murtaugh, Simon P. Graham, Simon P. Graham   +19 more
doaj   +1 more source

Molecular epidemiology of PRRSV: A phylogenetic perspective

Virus Research, 2010
Since its first discovery two decades ago, porcine reproductive and respiratory syndrome virus (PRRSV) has been the subject of intensive research due to its huge impact on the worldwide swine industry. Thanks to the phylogenetic analyses, much has been learned concerning the genetic diversity and evolution history of the virus.
Faaberg, KS, Hui, RKH, Leung, FCC, Stadejek, T, Murtaugh, MP, Wennblom, T, Lam, TTY, Hon, CC, Shi, M   +8 more
openaire   +4 more sources

Epidemiological surveillance and economic impact analysis of different porcine reproductive and respiratory syndrome virus infection statuses in 23 breeding pig farms in Hubei, China

Animal Diseases
Porcine reproductive and respiratory syndrome virus (PRRSV) has emerged as a significant threat to the pig farming industry worldwide, resulting in considerable economic losses. However, few reports detail its economic impact on the pig farming sector. A
Huifeng Zhao, Jingwei Zhou, Min Zhang, Xiutao Yang, Zhaofang Xi, Qingxia Gao, Rui Fang, Pengfei Zhao, Junlong Zhao   +8 more
doaj   +1 more source

Tilmicosin inhibits the infections of currently prevalent porcine reproductive and respiratory syndrome viruses via the downregulation of CD163 expression

Virulence
Porcine reproductive and respiratory syndrome virus (PRRSV) has a disastrous impact on the global swine industry. Even though PRRS commercial vaccines can provide homologous protection, broadly effective anti-PRRSV strategies are still in urgent need ...
Ming Qiu, Xinshuai Li, Shuai Li, Shubin Li, Ningjun Xie, Zhe Sun, Hong Lin, Jianzhong Zhu, Kegong Tian, Nanhua Chen   +9 more
doaj   +1 more source

A centralised immunogen approach to develop a more broadly protective modified live porcine reproductive and respiratory syndrome virus 1 vaccine candidate

npj Vaccines
More efficacious vaccines are required to improve control of porcine reproductive and respiratory syndrome viruses (PRRSV). One strategy that has shown promise is the use of centralized antigens, generated from consensus sequence data. Here, we evaluated
Rory C. F. de Brito, Yashar Sadigh, Joseph Bowman, Stephanie Clive, Ben Jackson, Miriam Pedrera, Fraser Crofts, Matthieu Bernard, Fabian Z. X. Lean, Alejandro Núñez, Julian Seago, Jean-Pierre Frossard, Simon P. Graham   +12 more
doaj   +1 more source