Results 91 to 100 of about 3,665 (185)

Constructing and interpreting a large-scale variant effect map for an ultrarare disease gene: Comprehensive prediction of the functional impact of PSAT1 genotypes.

, 2023
Reduced activity of the enzymes encoded by PHGDH, PSAT1, and PSPH causes a set of ultrarare, autosomal recessive diseases known as serine biosynthesis defects.
Richard N McLaughlin, Martin S Timour, Michael J Xie, Katherine Owens, Michelle Tang, Aimée M Dudley, Gareth A Cromie, J Nathan Kutz, Ayman W El-Hattab   +8 more
core   +1 more source

Serine auxotrophy is a targetable vulnerability driven by PSAT1 suppression in AML

Abstract Serine metabolism is of growing biologic and therapeutic interest in cancer. Upregulation of the serine synthesis pathway (SSP) can fuel tumor growth, and cancers with this phenotype are often sensitive to SSP inhibitors.
Ilias Sinanidis, Panagiotis Tsakiroglou, Benjamin Dubner, Rebecca Foertsch, Julia Gondek, InYoung Choi, Bogdan Paun, Liang Zhao, Gabriel Ghiaur, W. Brian Dalton   +9 more
openaire   +2 more sources

Abstract 2845: The role of PSAT1 in triple negative breast cancer metastasis

Cancer Research, 2019
Abstract Breast cancer is the number one diagnosed cancer type among women in the United States (NCI). This disease can be stratified into different molecular subtypes, including triple negative breast cancer (TNBC), each of which can have different therapeutic options, patient prognosis, and survival outcomes.
Stephanie Metcalf, Traci Kruer, Susan Dougherty, Rumeysa Biyik-Sit, Carolyn Klinge, Brian Clem   +5 more
openaire   +1 more source

Overexpression of phosphoserine aminotransferase PSAT1 stimulates cell growth and increases chemoresistance of colon cancer cells-4

, 2011
Copyright information:Taken from "Overexpression of phosphoserine aminotransferase PSAT1 stimulates cell growth and increases chemoresistance of colon cancer cells"http://www.molecular-cancer.com/content/7/1/14Molecular Cancer 2008;7():14-14.Published ...
Céline Gongora (86934), Emmanuel Conseiller (86931), Caroline Fraslon (86930), Vincent Denis (86928), Virginie Copois (86926), Nicole Bec (86678), Caroline Bascoul-Mollevi (86927), Franck Molina (86932), Bruno Robert (86929), Pierre Martineau (6238), Maguy Del Rio (86933), Christian Larroque (86679), Nadia Vié (86925)   +12 more
core   +1 more source

Supplementary Figure S6 from Serine Biosynthesis Is a Metabolic Vulnerability in IDH2-Driven Breast Cancer Progression

, 2021
Supplementary Figure S6. Decreased serine synthesis with CRISPR knockout of PHGDH and PSAT1 with IDH2 overexpression A - Western blot shows the CRISPR-Cas9 based knockout of PSAT1 and the partial and complete knockout of two PHGDH clones (different ...
Neta Erez (14944681), Eytan Ruppin (14941596), Georgina D. Barnabas (14944800), Lir Beck (14944809), Tamar Geiger (39413), Joo Sang Lee (14944803), Livnat Jerby-Arnon (14944812), Tamar Shami (14944806), Michal Harel (162894), Michael Selitrennik (14924883)   +9 more
core   +1 more source

PSAT1 enhances the efficacy of the prognosis estimation nomogram model in stage-based clear cell renal cell carcinoma

BMC Cancer
Background Clear cell renal cell carcinoma (ccRCC) is associated with a high prevalence of cancer-related deaths. The survival rates of patients are significantly lower in late-stage ccRCC than in early-stage ccRCC, due to the spread and metastasis of ...
Jun Wang, Xiaoming He, Yuanyuan Mi, Yong Q. Chen, Jie Li, Rong Wang   +5 more
doaj   +1 more source

PHGDH and PSAT1 protein expression in PBMC cells infected with HIV-1 and HIV-2 determined by Western blot.

, 2016
(A) PHGDH and (B) PSAT1 protein expression in PBMC cells infected with HIV-1 and HIV-2 determined by Western blot. Lane 1 is denoted as no virus infection control, Lane 2 is denoted as HIV-1 (MN) infected PBMC and Lane 3 is denoted as HIV-2 (ROD ...
Indira Hewlett (329203), Santanu Biswas (2181154), Viswanath Ragupathy (656191), Sherwin Lee (656192), Krishnakumar Devadas (196381), Owen Wood (196407), Mohan Haleyurgirisetty (2181152)   +6 more
core   +1 more source

Overexpression of PSAT1 regulated by G9A sustains cell proliferation in colorectal cancer [PDF]

Signal Transduction and Targeted Therapy, 2020
Huijuan Wang, Longzhen Cui, Dandan Li, Ming Fan, Zhangnan Liu, Chunqi Liu, Sijing Pan, Lei Zhang, Hailong Zhang, Yinglan Zhao   +9 more
openaire   +2 more sources

Overexpression of phosphoserine aminotransferase PSAT1 stimulates cell growth and increases chemoresistance of colon cancer cells-5

, 2011
Copyright information:Taken from "Overexpression of phosphoserine aminotransferase PSAT1 stimulates cell growth and increases chemoresistance of colon cancer cells"http://www.molecular-cancer.com/content/7/1/14Molecular Cancer 2008;7():14-14.Published ...
Céline Gongora (86934), Emmanuel Conseiller (86931), Caroline Fraslon (86930), Vincent Denis (86928), Virginie Copois (86926), Nicole Bec (86678), Caroline Bascoul-Mollevi (86927), Franck Molina (86932), Bruno Robert (86929), Pierre Martineau (6238), Maguy Del Rio (86933), Christian Larroque (86679), Nadia Vié (86925)   +12 more
core   +1 more source

PSAT1 gene variant causes mild serine deficiency: clinical and genetic analysis of ichthyosis combined with peripheral neuropathy [PDF]

Linchuang erke zazhi
Objective To investigate the clinical classification, genetic basis, and diagnostic and treatment strategies for serine deficiency caused by PSAT1 gene variants, in order to improve clinical recognition of this disorder.
HUANG Haisheng, ZHAO Anqi, ZENG Qin, WANG Yumeng, HE Wei, LI Ming
doaj   +1 more source