Results 71 to 80 of about 3,801 (180)

Phosphoserine Aminotransferase1 Is Part of the Phosphorylated Pathways for Serine Biosynthesis and Essential for Light and Sugar-Dependent Growth Promotion

Frontiers in Plant Science, 2018
The phosphorylated pathway of serine biosynthesis represents an important pathway in plants. The pathway consist of three reactions catalyzed by the phosphoglycerate dehydrogenase, the phosphoserine aminotransferase and the phosphoserine phosphatase, and
Sabine Wulfert, Stephan Krueger
doaj   +1 more source

Relationship Between Central Sensitization and Genetic Polymorphisms—A Case–Control Study in Fibromyalgia

European Journal of Pain, Volume 30, Issue 6, July 2026.
ABSTRACT Background Fibromyalgia is a syndrome characterised by widespread chronic pain, which is believed to be mediated by a state of central sensitisation (CS). Based on the hypothesis that CS itself could have genetic determinants, our aim was to further explore this pathway.
Nicolas Macian, Christian Dualé, Marine Delay, Vincent Leray, Bruno Pereira, Yoan Renaud, Yvonne Gloor, Jules Desmeules, Gisèle Pickering   +8 more
wiley   +1 more source

The unique catalytic properties of PSAT1 mediate metabolic adaptation to glutamine blockade

Nature Metabolism
Cultured cancer cells frequently rely on the consumption of glutamine and its subsequent hydrolysis by glutaminase (GLS). However, this metabolic addiction can be lost in the tumour microenvironment, rendering GLS inhibitors ineffective in the clinic. Here we show that glutamine-addicted breast cancer cells adapt to chronic glutamine starvation, or GLS
Yijian Qiu, Olivia T. Stamatatos, Qingting Hu, Jed Ruiter Swain, Suzanne Russo, Ava Sann, Ana S. H. Costa, Sara Violante, David L. Spector, Justin R. Cross, Michael J. Lukey   +10 more
openaire   +2 more sources

CRISPR‐Based Gene Dependency Screens Reveal Mechanism of BRAF Inhibitor Resistance in Anaplastic Thyroid Cancer

Molecular Carcinogenesis, Volume 65, Issue 7, Page 874-887, July 2026.
ABSTRACT Anaplastic thyroid cancer (ATC) is the most aggressive form of thyroid cancer. Despite recent advances in treating BRAFV600E‐driven ATC, therapy resistance remains a significant challenge, often resulting in disease progression and death.
Shawn Noronha, Yue Liu, Gaga Geneti, Haojian Li, Xiaolin Wu, David Sun, Vaibhavi Gujar, Takashi Furusawa, Alexei Lobanov, Maggie Cam, Lipika R. Pal, Nishanth U. Nair, Chi‐Ping Day, Eytan Ruppin, Chandrayee Ghosh, Jiangnan Hu, Bhavishya Ramamoorthy, Suresh Kumar, Thorkell Andresson, King Chan, Maura O'Neill, Raj Chari, Yves Pommier, Jaydira Del Rivero, Urbain Weyemi, Electron Kebebew, Myriem Boufraqech   +26 more
wiley   +1 more source

Abstract 2845: The role of PSAT1 in triple negative breast cancer metastasis

Cancer Research, 2019
Abstract Breast cancer is the number one diagnosed cancer type among women in the United States (NCI). This disease can be stratified into different molecular subtypes, including triple negative breast cancer (TNBC), each of which can have different therapeutic options, patient prognosis, and survival outcomes.
Stephanie Metcalf, Traci Kruer, Susan Dougherty, Rumeysa Biyik-Sit, Carolyn Klinge, Brian Clem   +5 more
openaire   +1 more source

Branched‐Chain Amino and Keto Acids Reduce Hepatocyte Lipid Droplet Size and Number via Distinct Proteomic Pathways

PROTEOMICS, Volume 26, Issue 7, Page 146-157, July 2026.
ABSTRACT Branched‐chain amino acids (BCAA) and their corresponding keto acids (BCKA) have been associated with changes in hepatic lipid metabolism and the resulting alterations in intracellular triglyceride concentrations. In this study, we utilized a previously established hepatocyte model to investigate the impact of BCAA and BCKA supplementation on ...
Jayasimha R. Daddam, Mounica Sura, Edward Kolodziej, Maria Gojcaj, Zheng Zhou   +4 more
wiley   +1 more source

Case Report of Dual Variants in SLC1A4 and APOE: A Possible Link Between Amino Acid and Lipid Metabolism

Clinical Case Reports, Volume 14, Issue 6, June 2026.
ABSTRACT Spastic tetraplegia, thin corpus callosum, and progressive microcephaly (SPATCCM) is a rare autosomal recessive neurodevelopmental disorder linked to biallelic variants in the SLC1A4 gene, which encodes the ASCT1 amino acid transporter critical for neutral amino acid uptake in neurons.
Mohammed Qaisiya, Kenana Altell, Wasef Alhroub, Mahmoud Ramlawe, Elisabetta Battocchio, Fabrizia Guarnieri, Mu'taz Altamimi   +6 more
wiley   +1 more source

Ferroptosis in breast cancer: From adipocyte–immune–iron regulation to therapeutic application

Clinical and Translational Medicine, Volume 16, Issue 6, June 2026.
Ferroptosis in breast cancer is regulated by an integrated adipocyte–immune–iron network rather than by tumour‐intrinsic pathways alone. Adipocyte‐derived lipid substrates and redox metabolites, immune‐cell‐mediated cytokine signalling and iron‐dependent oxidative stress collectively shape a dynamic ferroptosis ecosystem that can shift tumours towards ...
Juan Sun, Yang Qu, Ru Yao, Yidong Zhou
wiley   +1 more source

Plasmacytoid Dendritic Cells Exhibit High Transferrin Receptor Expression Without Iron Accumulation

European Journal of Immunology, Volume 56, Issue 6, June 2026.
• pDCs are defined by high surface TFRC expression and dynamic iron flux, distinguishing them from conventional dendritic cell subsets. • In the Iron proteome, pDC are enriched for mitochondrial heme and Fe–S proteins but have similar iron storage to cDC. • Iron chelation does not disrupt pDC type‐1 IFN production. ABSTRACT Plasmacytoid dendritic cells
Carrie Corkish, Simon O'Shaughnessy, Claire Lin, Sophia Wugk, Sarah Kenny, Linda Sinclair, Suzanne Cloonan, David Finlay   +7 more
wiley   +1 more source

Abstract 3563: Potential role for a phosphoserine aminotransferase 1 and pyruvate kinase M2 (PSAT1:PKM2) functional interaction in lung cancer cells

, 2017
Cellular production of serine provides precursors for numerous anabolic reactions, particularly for proteins and nucleic acid synthesis and for one carbon metabolism, and this pathway has been demonstrated to be elevated in many different cancer types ...
Traci Kruer, John O. Trent, James Bradley, Brian F. Clem, Michael Merchant, Rumeysa B. Sit   +5 more
core   +1 more source