Results 81 to 90 of about 3,665 (185)

The Role of One‐Carbon Metabolism in Cancer and Its Therapeutic Significance

MedComm – Oncology, Volume 5, Issue 1, March 2026.
One‐Carbon metabolism in T‐cell activation and tumor competition. T‐cell activation shifts metabolic pathways, promoting anabolic metabolism and bioenergetic capacity. One‐carbon metabolism plays a crucial role in histone and DNA methylation in activated T cells.
Yuting Jiang, Guoliang Zhou, Qian Zhang, Shengtao Zhou   +3 more
wiley   +1 more source

Inhibition of signaling protein ERN1 increases the sensitivity of serine synthesis gene expressions to glucose and glutamine deprivations in U87MG glioblastoma cells

Endocrine Regulations
Objective. Glucose and glutamine supply as well as serine synthesis and endoplasmic reticulum (ER) stress are important factors of glioblastoma growth. Previous studies showed that the knockdown of ERN1 (ER to nucleus signaling 1) suppressed glioblastoma
Minchenko Oleksandr H., Sliusar Myroslava Y., Khita Olena O., Minchenko Dmytro O., Viletska Yuliia M., Halkin Oleh V., Levadna Liudmyla O., Cherednychenko Anastasiia A., Khikhlo Yevgen P.   +8 more
doaj   +1 more source

Characterizing Stage‐Specific Cellular Dynamics and Microenvironmental Remodeling in Lung Adenocarcinoma by Single‐Cell RNA Sequencing

Advanced Science, Volume 13, Issue 9, 13 February 2026.
This study integrated early‐stage patient specimens with publicly available datasets encompassing non‐malignant lung tissues and advanced‐stage LUAD through single‐cell sequencing, revealing a dynamically remodeled tumor microenvironment characterized by a hypoxia‐adapted malignant subset (C5), immunosuppressive LGMN+ macrophages, STAT1‐driven ...
Bomiao Qing, Xiaolan Li, Xiang He, Junyi Wang, Yi Yang, Manling Jiang, Bingbing Yan, Lei Zhang, Anying Xiong, Qin Ran, Guoping Li   +10 more
wiley   +1 more source

Overexpression of phosphoserine aminotransferase PSAT1 stimulates cell growth and increases chemoresistance of colon cancer cells-6

, 2011
Copyright information:Taken from "Overexpression of phosphoserine aminotransferase PSAT1 stimulates cell growth and increases chemoresistance of colon cancer cells"http://www.molecular-cancer.com/content/7/1/14Molecular Cancer 2008;7():14-14.Published ...
Céline Gongora (86934), Emmanuel Conseiller (86931), Caroline Fraslon (86930), Vincent Denis (86928), Virginie Copois (86926), Nicole Bec (86678), Caroline Bascoul-Mollevi (86927), Franck Molina (86932), Bruno Robert (86929), Pierre Martineau (6238), Maguy Del Rio (86933), Christian Larroque (86679), Nadia Vié (86925)   +12 more
core   +1 more source

Additional file 1 of p63 orchestrates serine and one carbon metabolism enzymes expression in head and neck cancer

, 2023
Additional file 1: Fig S1. Serine and OCM enzymes are differentially expressed in single-cell RNAseq of HNSCC and leukoplakia samples. (a) Average expression of serine and one carbon metabolism enzymes in single-cell RNA sequencing of normal and HNSCC ...
Xue Yang (17369186), Carlo Ganini (17369183), Francesca Bernassola (17369195), Angela Cappello (17369174), Giulia Tosetti (17369177), Artem Smirnov (17369180), Eleonora Candi (17369198), Yufang Shi (17369189), Ying Wang (17369192), Gerry Melino (12209138)   +9 more
core   +1 more source

Overexpression of PSAT1 Gene is a Favorable Prognostic Marker in Lower-Grade Gliomas and Predicts a Favorable Outcome in Patients with IDH1 Mutations and Chromosome 1p19q Codeletion

, 2019
Patients with lower-grade gliomas (LGGs) have highly diverse clinical outcomes. Although histological features and molecular markers have been used to predict prognosis, the identification of new biomarkers for the accurate prediction of patient outcomes
Yung-Chieh Chan, Shang-Yu Huang, Shang-Pen Huang, Yuan-Feng Lin   +3 more
core   +1 more source

Supplementary Figure S7 from Serine Biosynthesis Is a Metabolic Vulnerability in IDH2-Driven Breast Cancer Progression

, 2021
Supplementary Figure S7. Metabolic effects of PHGDH and PSAT1 knockouts with mCherry (control) overexpression A-F - Isotopologue abundances of glutamate (A), alpha-ketoglutarate (B), citrate (C), fumarate (D) malate (E) and aspartate (F) from 13C5 ...
Neta Erez (14944681), Eytan Ruppin (14941596), Georgina D. Barnabas (14944800), Lir Beck (14944809), Tamar Geiger (39413), Joo Sang Lee (14944803), Livnat Jerby-Arnon (14944812), Tamar Shami (14944806), Michal Harel (162894), Michael Selitrennik (14924883)   +9 more
core   +1 more source

Overexpression of phosphoserine aminotransferase PSAT1 stimulates cell growth and increases chemoresistance of colon cancer cells-3

, 2011
Copyright information:Taken from "Overexpression of phosphoserine aminotransferase PSAT1 stimulates cell growth and increases chemoresistance of colon cancer cells"http://www.molecular-cancer.com/content/7/1/14Molecular Cancer 2008;7():14-14.Published ...
Céline Gongora (86934), Emmanuel Conseiller (86931), Caroline Fraslon (86930), Vincent Denis (86928), Virginie Copois (86926), Nicole Bec (86678), Caroline Bascoul-Mollevi (86927), Franck Molina (86932), Bruno Robert (86929), Pierre Martineau (6238), Maguy Del Rio (86933), Christian Larroque (86679), Nadia Vié (86925)   +12 more
core   +1 more source

Examination of the effects of microRNA-145-5p and phosphoserine aminotransferase 1 in colon cancer

, 2022
Previous studies manifested that microRNA-145-5p is pivotal in the development of various cancers. Nevertheless, the potential function of microRNA-145-5p in colorectal cancer remains unclear.
Ruliang Ding (12643447), Jinfan Shao (12643453), Liang Huang (114017), Wenfeng Yu (6520763), Xijuan Xu (12643456), Weiwen Hong (12643450)   +5 more
core   +1 more source

Additional file 2 of PSAT1 is regulated by ATF4 and enhances cell proliferation via the GSK3β/β-catenin/cyclin D1 signaling pathway in ER-negative breast cancer

, 2017
Effects of PSAT1 on the migration, invasion and apoptosis of ER-negative breast cancer cells. (A) Transwell assays were used to investigate changes in cell migration and invasion. **P 
Song Gao (131209), Zilong You (4670989), Anqi Ge (4670995), Shipeng Ning (4670992), Shouping Xu (3727744), Yashuang Zhao (391596), Da Pang (110728)   +6 more
core   +1 more source