Results 61 to 70 of about 3,887 (161)

Phosphoserine Aminotransferase1 Is Part of the Phosphorylated Pathways for Serine Biosynthesis and Essential for Light and Sugar-Dependent Growth Promotion

Frontiers in Plant Science, 2018
The phosphorylated pathway of serine biosynthesis represents an important pathway in plants. The pathway consist of three reactions catalyzed by the phosphoglycerate dehydrogenase, the phosphoserine aminotransferase and the phosphoserine phosphatase, and
Sabine Wulfert, Stephan Krueger
doaj   +1 more source

LncRNA MEG8 promotes NSCLC progression by modulating the miR-15a-5p-miR-15b-5p/PSAT1 axis

Cancer Cell International, 2021
Background Non-small cell lung cancer (NSCLC) is the most common tumor with severe morbidity and high mortality. Long non-coding RNAs (lncRNAs) as crucial regulators participate in multiple cancer progressions.
Kai Guo, Di Qi, Bo Huang
doaj   +1 more source

The unique catalytic properties of PSAT1 mediate metabolic adaptation to glutamine blockade

Nature Metabolism
Cultured cancer cells frequently rely on the consumption of glutamine and its subsequent hydrolysis by glutaminase (GLS). However, this metabolic addiction can be lost in the tumour microenvironment, rendering GLS inhibitors ineffective in the clinic. Here we show that glutamine-addicted breast cancer cells adapt to chronic glutamine starvation, or GLS
Yijian Qiu, Olivia T. Stamatatos, Qingting Hu, Jed Ruiter Swain, Suzanne Russo, Ava Sann, Ana S. H. Costa, Sara Violante, David L. Spector, Justin R. Cross, Michael J. Lukey   +10 more
openaire   +2 more sources

Changes in expression of serine biosynthesis and integrated stress response genes during myogenic differentiation of C2C12 cells

Biochemistry and Biophysics Reports, 2019
Skeletal muscle is a highly metabolic and dynamic tissue that is formed through the complex and well-organised process of myogenesis. Although there is a good understanding about the role of the Muscle Regulatory Factors during myogenesis, little is ...
Madelaine C. Brearley, Congcong Li, Zoe C.T.R. Daniel, Paul T. Loughna, Tim Parr, John M. Brameld   +5 more
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Abstract 2845: The role of PSAT1 in triple negative breast cancer metastasis

Cancer Research, 2019
Abstract Breast cancer is the number one diagnosed cancer type among women in the United States (NCI). This disease can be stratified into different molecular subtypes, including triple negative breast cancer (TNBC), each of which can have different therapeutic options, patient prognosis, and survival outcomes.
Stephanie Metcalf, Traci Kruer, Susan Dougherty, Rumeysa Biyik-Sit, Carolyn Klinge, Brian Clem   +5 more
openaire   +1 more source

Abstract 3563: Potential role for a phosphoserine aminotransferase 1 and pyruvate kinase M2 (PSAT1:PKM2) functional interaction in lung cancer cells

, 2017
Cellular production of serine provides precursors for numerous anabolic reactions, particularly for proteins and nucleic acid synthesis and for one carbon metabolism, and this pathway has been demonstrated to be elevated in many different cancer types ...
Traci Kruer, John O. Trent, James Bradley, Brian F. Clem, Michael Merchant, Rumeysa B. Sit   +5 more
core   +1 more source

Hydrocortisone interacts with endoplasmic reticulum stress in hypoxic regulation of phosphoserine aminotransferase 1 gene expression differently in normal human astrocytes and glioblastoma cells

Endocrine Regulations
Objective. Endoplasmic reticulum (ER) stress and hypoxia are key factors for the effective growth of malignant tumors, including glioblastoma. The phosphoserine aminotransferase 1 (PSAT1) is an ER stress-responsive enzyme responsible for serine synthesis
Minchenko Oleksandr H., Abramchuk Anastasiia I., Khikhlo Yevgen P., Sliusar Myroslava Y., Halkin Oleh V., Luzina Olha Y., Danilovsryi Serhiy V., Viletska Yuliia M., Minchenko Dmytro O.   +8 more
doaj   +1 more source

Overexpression of phosphoserine aminotransferase PSAT1 stimulates cell growth and increases chemoresistance of colon cancer cells-0

, 2011
Copyright information:Taken from "Overexpression of phosphoserine aminotransferase PSAT1 stimulates cell growth and increases chemoresistance of colon cancer cells"http://www.molecular-cancer.com/content/7/1/14Molecular Cancer 2008;7():14-14.Published ...
Céline Gongora (86934), Emmanuel Conseiller (86931), Caroline Fraslon (86930), Vincent Denis (86928), Virginie Copois (86926), Nicole Bec (86678), Caroline Bascoul-Mollevi (86927), Franck Molina (86932), Bruno Robert (86929), Pierre Martineau (6238), Maguy Del Rio (86933), Christian Larroque (86679), Nadia Vié (86925)   +12 more
core   +1 more source

Inhibition of signaling protein ERN1 increases the sensitivity of serine synthesis gene expressions to glucose and glutamine deprivations in U87MG glioblastoma cells

Endocrine Regulations
Objective. Glucose and glutamine supply as well as serine synthesis and endoplasmic reticulum (ER) stress are important factors of glioblastoma growth. Previous studies showed that the knockdown of ERN1 (ER to nucleus signaling 1) suppressed glioblastoma
Minchenko Oleksandr H., Sliusar Myroslava Y., Khita Olena O., Minchenko Dmytro O., Viletska Yuliia M., Halkin Oleh V., Levadna Liudmyla O., Cherednychenko Anastasiia A., Khikhlo Yevgen P.   +8 more
doaj   +1 more source

MicroRNA-340 Inhibits Esophageal Cancer Cell Growth and Invasion by Targeting Phosphoserine Aminotransferase 1

Cellular Physiology and Biochemistry, 2015
Background/Aims: Emerging evidence indicates that microRNA (miR)-340 is downregulated in various human cancers, suggesting that it acts as a tumor suppressor.
Shuo Yan, Haosheng Jiang, Shiming Fang, Fang Yin, Zhenlei Wang, Yiping Jia, Xianjun Sun, Shaoqiu Wu, Tinghui Jiang, Aiwu Mao   +9 more
doaj   +1 more source