Results 181 to 190 of about 5,276 (193)

ADH1C inhibits progression of colorectal cancer through the ADH1C/PHGDH /PSAT1/serine metabolic pathway

Acta Pharmacologica Sinica, 2022
Colorectal cancer (CRC) is the third most common cancer in men and the second most common cancer in women worldwide. CRC is the second leading cause of cancer-related deaths. Although some progress in the treatment of CRC has been achieved, the molecular mechanism of CRC is still unclear.
Sha, Li, Hong, Yang, Wan, Li, Jin-Yi, Liu, Li-Wen, Ren, Yi-Hui, Yang, Bin-Bin, Ge, Yi-Zhi, Zhang, Wei-Qi, Fu, Xiang-Jin, Zheng, Guan-Hua, Du, Jin-Hua, Wang   +11 more
openaire   +2 more sources

PSAT1 Suppression Drives a Targetable Serine Dependence in AML

Blood
From antifolates to asparaginase to IDH inhibitors, targeting cancer metabolism has proven useful in heme malignancies. In solid tumors, a therapy with recent momentum is depriving cancer of serine. In vivo, this is done with a serine- and glycine-free (-SG) diet, which is tolerated by mice and can slow tumor ...
Ilias Sinanidis, Panagiotis Tsakiroglou, Rebecca Foertsch, Julia Gondek, Benjamin Dubner, InYoung Choi, Bogdan Paun, Liang Zhao, Everett Stone, George Georgiou, Gabriel Ghiaur, William Brian Dalton   +11 more
openaire   +1 more source

PSAT1 impairs ferroptosis and reduces immunotherapy efficacy via GPX4 hydroxylation

Nature Chemical Biology
Tumor cells adapt to the inflammatory tumor microenvironment (TME) and develop resistance to immunotherapy, with ferroptosis being a major form of tumor cell death. However, the mechanisms by which tumor cells coordinate TME stimuli and their unique metabolic traits to evade ferroptosis and develop resistance to immunotherapy remain unclear.
Peixiang Zheng, Zhiqiang Hu, Yuli Shen, Lina Gu, Yuan Ouyang, Yuran Duan, Guimei Ji, Bofei Dong, Yanni Lin, Ting Wen, Qi Tian, Yueru Hou, Qimin Zhou, Xue Sun, Xiaohan Chen, Katherine L. Wang, Shudi Luo, Shiqi Wu, Yuening Sun, Min Li, Liwei Xiao, Qingang Wu, Ying Meng, Guijun Liu, Zheng Wang, Xueli Bai, Shengzhong Duan, Yuan Ding, Yanli Bi, Yuhao Wang, Gaopeng Li, Xiaoguang Liu, Zhimin Lu, Xiaohong Wu, Zhiyuan Tang, Daqian Xu   +35 more
openaire   +2 more sources

IL-35 suppresses pathogenic T cell response in atopic dermatitis by inhibiting PSAT1 activation

The Journal of Immunology, 2022
Abstract Interleukin 35 (IL-35) is a member of the IL-12 family and immune-suppressive cytokine and a critical regulator of immunity during autoimmune and infectious diseases. However, it is unclear whether IL-35 can control skin inflammation by regulating the biosynthesis of biomolecules.
Hyo Jung Lim, Jong Yeong Lee, Jin kyeong Choi   +2 more
openaire   +1 more source

Abstract 12785: Psat1 Promotes Serine Synthesis Pathway and Cardiac Regeneration After Myocardial Infarction

Circulation, 2022
Introduction: Permanent loss of cardiomyocytes (CM) after myocardial infarction (MI) and limited cardiac regenerative capacity lead to heart failure. The iPSC-derived extracellular vesicles (EV) have been shown to improve cardiac function and protection.
Ajit Magadum, Vandana Mallaredy, Rajika Roy, Chunlin Wang, Grace Grace, Zhongjian Cheng, May Truongcao, Darukeshwara Joladarashi, Charan Thej Gurrala, Vagner O Rigaud, Anna Maria Lucchese, Cindy Benedict, Mohsin Khan, Celio X Santos, Ajay M Shah, Walter J Koch, Raj Kishore   +16 more
openaire   +1 more source

Novel and recurrent PHGDH and PSAT1 mutations in Chinese patients with Neu-Laxova syndrome

European Journal of Dermatology, 2019
Neu-Laxova syndrome (NLS) is a rare hereditary disorder featuring intrauterine growth retardation, remarkable oedema with skin restriction, limb contracture, ichthyosis, and craniofacial anomaly. NLS shares multiple overlapping characteristics with several other inheritable refractory diseases: for example, harlequin foetus and restrictive dermopathy ...
Cheng, Ni, Ru-Hong, Cheng, Jia, Zhang, Jian-Ying, Liang, Ru-Qu, Wei, Ming, Li, Zhi-Rong, Yao   +6 more
openaire   +2 more sources

Vitamin D3 alleviates pulmonary fibrosis by regulating the MAPK pathway via targeting PSAT1 expression in vivo and in vitro

International Immunopharmacology, 2021
Qi Ding, Gonghao Xu, Yuanyuan Shi
exaly  

Regorafenib induces lethal autophagy arrest by stabilizing PSAT1 in glioblastoma

Autophagy, 2020
, Yunlong Lei, Yuelong Wang
exaly  

Overexpression of PSAT1 Gene is a Favorable Prognostic Marker in Lower-Grade Gliomas and Predicts a Favorable Outcome in Patients with IDH1 Mutations and Chromosome 1p19q Codeletion

Cancers, 2020
Yuan-Feng Lin
exaly  

PSAT1 regulates cyclin D1 degradation and sustains proliferation of non‐small cell lung cancer cells

International Journal of Cancer, 2015
Yi Yang, Yanbing Li
exaly