Results 1 to 10 of about 14,046 (214)

A Selective Irreversible Inhibitor of Furin Does Not Prevent Pseudomonas Aeruginosa Exotoxin A-Induced Airway Epithelial Cytotoxicity. [PDF]

PLoS ONE, 2016
Many bacterial and viral pathogens (or their toxins), including Pseudomonas aeruginosa exotoxin A, require processing by host pro-protein convertases such as furin to cause disease.
Timothy E G Ferguson, James A Reihill, Brian Walker, Robert A Hamilton, S Lorraine Martin   +4 more
doaj   +11 more sources

Pseudomonas aeruginosa exotoxin A-induced hepatotoxicity in dynamics: an animal model in white mice [PDF]

Саратовский научно-медицинский журнал, 2015
Purpose: to study biochemical indices of peripheral blood which show organs functional changes. Material and Methods. The experiments were carried out on white mice in dynamics development of pseudomonas aeruginosa caused by intraperitoneal injection of ...
Morrison A.V., Popovich V.I., Morrison V.V.   +2 more
doaj  

APseudomonas aeruginosaalginate-exotoxin A conjugate that elicits anti-alginate and exotoxin A-neutralizing antibodies [PDF]

FEMS Microbiology Letters, 1991
Pseudomonas aeruginosa alginate was covalently coupled to exotoxin A by reductive amination using adipic acid dihydrazide as spacer. The conjugate was composed of 25% alginate and 75% exotoxin A and possessed an average molecular mass higher than 700 kDa as determined by polyacrylamide gel electrophoresis.
D, Coin, M J, Vacheron, M, Guinand, G, Michel   +3 more
openaire   +2 more sources

LRP1B functions as a receptor for Pseudomonas exotoxin

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2005
Pseudomonas aeruginosa is an opportunistic pathogen that produces several virulence factors, among them Pseudomonas Exotoxin A (PE). Previously, low-density lipoprotein receptor-related protein 1 (LRP 1) was shown to be the primary receptor for PE. In this report, we show that a close family member, LRP 1B, can also function as a receptor.
Pastrana, Diana V., Hanson, Alison J., Knisely, Jane, Bu, Guojun, FitzGerald, David J.   +4 more
openaire   +3 more sources

The Immunomodulatory Effect of Recombinant Exotoxin A of Pseudomonas Aeruginosa on Dendritic Cells Extracted from Mice Spleen [PDF]

Journal of Advanced Biomedical Sciences, 2014
Background & Objective: Dendritic cell (DC) is as a key cell in activation of immune response against microbes and disease. Therefore, the effect of recombinant exotoxin A of Pseudomonas aeruginosa on the maturity and the activation of DCs was evaluated ...
Mohammad Hossein Karimi, Aziz Japoni, Manouchehr Rasouli, Salimeh Ebrahimnezhad   +3 more
doaj  

Quercus infectoria gall extracts reduce quorum sensing-controlled virulence factors production and biofilm formation in Pseudomonas aeruginosa recovered from burn wounds

BMC Complementary and Alternative Medicine, 2019
Background Quercus gall extracts’ ability to kill pathogens in vitro and even removal of chronic drug-resistant infections has been reported by several studies.
Akhter Ahmed Ahmed, Fraidoon Abdulqadir Salih   +1 more
doaj   +1 more source

Prophylactic and therapeutic protection of human IgG purified from sera containing anti-exotoxin A titers against pneumonia caused by Pseudomonas aeruginosa

Human Vaccines & Immunotherapeutics, 2019
Antibodies are effective alternative tools to combat infections caused by Pseudomonas aeruginosa (PA), especially multi-drug-resistant PA. Thus, to solve the urgent need for an anti-PA antibody drug, we hypothesized that anti-PA intravenous ...
Jin Zhang, Chuang Wan, Bo Yu, Chen Gao, Liqun Zhao, Xin Cheng, Feng Yang, Hao Gu, Quanming Zou, Jiang Gu, Xingyong Wang   +10 more
doaj   +1 more source

A nontoxicPseudomonas exotoxin a induces active immunity and passive protective antibody againstPseudomonas exotoxin a intoxication

Journal of Biomedical Science, 1999
Pseudomonas exotoxin A (PE) is one of the most potent cytotoxic agents produced by Pseudomonas aeruginosa. In this study, we examined the possibility of using PE with a deletion of 38 carboxyl-terminal amino acid residues, designated PE(Delta576-613), for active immunization against PE-mediated disease.
T Y, Chen, C P, Lin, C C, Loa, T L, Chen, H F, Shang, J, Hwang, C F, Hui   +6 more
openaire   +2 more sources

Effect of Pseudomonas aeruginosa Pure Exotoxin A on Mice WBC in Comparison with Human WBC Contaminated by Pseudomonas aeruginosa

Armaghane Danesh Bimonthly Journal, 2008
Introduction & Objective: Pseudomonas aeruginosa is a gram negative bacterial. This bacterium is resistant to many antibiotics and chemical disinfectants.
M Naghmachi, A Sharifi, J Kohanteb
doaj  

Crystal Structure of Exotoxin A from Aeromonas Pathogenic Species

Toxins, 2020
Aeromonas exotoxin A (AE) is a bacterial virulence factor recently discovered in a clinical case of necrotising fasciitis caused by the flesh-eating Aeromonas hydrophila.
Geoffrey Masuyer
doaj   +1 more source