Results 111 to 120 of about 25,696 (291)

Extracellular ATP: an emerging multifaceted regulator of plant fitness

Plant Biotechnology Journal, Volume 23, Issue 5, Page 1771-1782, May 2025.
Summary Adenosine 5′‐triphosphate (ATP) is the energy currency of living organisms and the primary form of organic phosphate (Po) involved in cellular metabolism. In plants, some ATP is released into the extracellular matrix (ECM) in response to various stimuli, where it functions as extracellular ATP (eATP), a key signalling molecule.
De Peng Yuan, Daewon Kim, Yuan Hu Xuan
wiley   +1 more source

Analysis of Multiple Isoenzyme Expression Among Twenty-Two Species of Mycoplasma and Acholeplasma [PDF]

, 1981
Crude extracts of triple-cloned, purified cultures of 22 species of Mycoplasma and Acholeplasma were examined for expression of 21 isozyme systems routinely used to type mammalian cells. Nine previously described enzymes (purine nucleoside phosphorylase,
Barile, Michael F., Grabowski, Marion W., O\u27Brien, Stephen J., Simonson, Janice M.   +3 more
core   +1 more source

Triazole-Based Compound as a Candidate To Develop Novel Medicines To Treat Toxoplasmosis [PDF]

, 2014
This article reports anti-Toxoplasma gondii activity of 3-(thiophen-2-yl)-1,2,4-triazole-5-thione. The compound displayed significant and reproducible antiparasitic effects at nontoxic concentrations for the host cells, with an experimentally determined
Dzitko, Katarzyna, Paneth, Agata, Paneth, Piotr, Pawełczyk, Jakub, Plech, Tomasz, Węglińska, Lidia   +5 more
core   +1 more source

Computational quantum chemistry, molecular docking, and ADMET predictions of imidazole alkaloids of Pilocarpus microphyllus with schistosomicidal properties.

PLoS ONE, 2018
Schistosomiasis affects million people and its control is widely dependent on a single drug, praziquantel. Computational chemistry has led to the development of new tools that predict molecular properties related to pharmacological potential.
Jefferson A Rocha, Nayra C S Rego, Bruna T S Carvalho, Francisco I Silva, Jose A Sousa, Ricardo M Ramos, Ionara N G Passos, Josué de Moraes, Jose R S A Leite, Francisco C A Lima   +9 more
doaj   +1 more source

Metabolic growth differences between Gymnocypris przewalskii and Gymnocypris eckloni: A quantitative proteomic perspective

Journal of the World Aquaculture Society, Volume 56, Issue 2, April 2025.
Abstract Metabolism plays a crucial role in the growth rate of species. Proteomics serves as a potent tool to explore these metabolic changes. Herein, we investigated the metabolic growth differences in Gymnocypris przewalskii (GP) and Gymnocypris ecklon (GE). After 9 months of culture, the growth rate of GP was slower than that of GE (p < 0.05), while
Junming Zhou, Yun Zhao
wiley   +1 more source

Enzyme kinetics, structural analysis and molecular modeling studies on a series of Schistosoma mansoni PNP inhibitors [PDF]

, 2011
The enzyme purine nucleoside phosphorylase from Schistosoma mansoni (SmPNP) is an attractive molecular target for the development of novel drugs against schistosomiasis, a neglected tropical disease that affects about 200 million people worldwide. In the
ANDRICOPULO, Adriano Defini, CASTILHO, Marcelo S, KROGH, Renata, OLIVA, Glaucius, PEREIRA, Humberto d'Muniz, POSTIGO, Matheus P, TERNI, Marcela F   +6 more
core   +1 more source

Pediococcus acidilactici GR-5 alleviates hyperuricemia by degrading purine nucleosides and improving gut microbiota metabolism

npj Science of Food
Reducing intestinal absorption by degrading purine nucleosides has been shown to alleviate hyperuricemia (HUA). The probiotic Pediococcus acidilactici GR-5, derived from the traditional food “Jiangshui”, achieved efficient degradation of purine ...
Jing Ji, Zi-Yi An, Aman Khan, Liang Peng, Sourabh Kulshreshtha, El-Sayed Salama, Hui Yun, Pu Liu, Wei-Lin Jin, Xiangkai Li   +9 more
doaj   +1 more source

An improved technique for isolated perfusion of rat livers and an evaluation of perfusates [PDF]

, 1992
We have modified the apparatus for isolated rat liver perfusion (IPRL) in order to be able to perform two perfusions simultaneously. In addition, we studied the quality and stability of livers by comparison of five different perfusates: Blood (Group A ...
Liu, T, Mischinger, HJ, Nakamura, K, Rao, PN, Rubin, R, Starzl, TE, Todo, S, Walsh, TR   +7 more
core   +1 more source

Increased Adenine Nucleotide Degradation in Skeletal Muscle Atrophy [PDF]

, 2019
Adenine nucleotides (AdNs: ATP, ADP, AMP) are essential biological compounds that facilitate many necessary cellular processes by providing chemical energy, mediating intracellular signaling, and regulating protein metabolism and solubilization.
Brault, Jeffrey J., Hafen, Paul S., Miller, Spencer G.   +2 more
core   +1 more source

Immunodeficiency and autoimmunity: companions not opposites

The Journal of Clinical Investigation, 2022
Autoimmunity has long been regarded as the polar opposite of immunodeficiency, but clinical and experimental evidence refute this notion. Indeed, numerous inborn or acquired immunodeficiency syndromes are characterized by the development of autoimmune ...
David A. Fox
doaj   +1 more source