Results 111 to 120 of about 25,575 (276)

Mitochondrial metabolism of guanine nucleotides possible role of guanosine [PDF]

, 1989
The catabolism of intramitochondrial guanine nucleotides was examined. During 30 min incubation of rat liver mitochondria at 37°C in the presence of oligomycin and carboxyatractyloside, guanine and xanthine were formed and appeared in the medium.
Alexander M. Pimenov, Aprille, Bergmeyer, Bestwick, Dubiel, Gerhard Gerber, Mathias Ziegler, McKee, Park, Pimenov, Rusian T. Toguzov, Söling, Watkins, Wolfgang Dubiel, Wolfgang Henke, Yuri V. Tikhonov, Ziegler, Ziegler   +17 more
core   +1 more source

A purine nucleoside phosphorylase in Solanum tuberosum L. (potato) with specificity for cytokinins contributes to the duration of tuber endodormancy.

Biochemical Journal, 2014
StCKP1 (Solanum tuberosum cytokinin riboside phosphorylase) catalyses the interconversion of the N9-riboside form of the plant hormone CK (cytokinin), a subset of purines, with its most active free base form.
J. R. Bromley, Barbara J Warnes, C. Newell, Jamie C P Thomson, C. James, C. Turnbull, D. Hanke   +6 more
semanticscholar   +1 more source

CD147 Mediates the Metabolic Reprogramming of Cancer Associated Fibroblasts Induced by EVs Released by Differentiating Cancer Stem Cells

Journal of Extracellular Biology, Volume 4, Issue 3, March 2025.
ABSTRACT Several reports have demonstrated that CD147, an N‐glycosylated protein that is exchanged by cells in soluble form or through small extracellular vesicles (sEVs), can promote cancer progression. However, its activity related to EVs in colorectal cancer (CRC) is still not fully understood.
Filomena Colella, Federica Calapà, Giulia Artemi, Erica Pazzaglia, Rita Colonna, Sara Vitale, Giacomo Lazzarino, Federica Vincenzoni, Micol Eleonora Fiori, Ruggero De Maria, Sara Lucchisani, Giannicola Genovese, Luigi Perelli, Barbara Tavazzi, Alessandro Sgambato, Donatella Lucchetti   +15 more
wiley   +1 more source

Targeted enzyme prodrug therapy for metastatic prostate cancer – a comparative study of L-methioninase, purine nucleoside phosphorylase, and cytosine deaminase

Journal of Biomedical Sciences, 2014
BackgroundEnzyme prodrug therapy shows promise for the treatment of solid tumors, but current approaches lack effective/safe delivery strategies. To address this, we previously developed three enzyme-containing fusion proteins targeted via annexin V to ...
Katrin P. Guillen, C. Kurkjian, R. Harrison   +2 more
semanticscholar   +1 more source

Guanylate Kinase 1 Deficiency: A Novel and Potentially Treatable Mitochondrial DNA Depletion/Deletions Disease

Annals of Neurology, Volume 96, Issue 6, Page 1209-1224, December 2024.
Objective Mitochondrial DNA (mtDNA) depletion/deletions syndrome (MDDS) comprises a group of diseases caused by primary autosomal defects of mtDNA maintenance. Our objective was to study the etiology of MDDS in 4 patients who lack pathogenic variants in known genetic causes.
Agustin Hidalgo‐Gutierrez, Jonathan Shintaku, Javier Ramon, Eliana Barriocanal‐Casado, Alba Pesini, Russell P. Saneto, Gloria Garrabou, Jose Cesar Milisenda, Ana Matas‐Garcia, Laura Gort, Olatz Ugarteburu, Yue Gu, Lahari Koganti, Tian Wang, Saba Tadesse, Megi Meneri, Monica Sciacco, Shuang Wang, Kurenai Tanji, Marshall S. Horwitz, Michael O. Dorschner, Mahesh Mansukhani, Giacomo Pietro Comi, Dario Ronchi, Ramon Marti, Antonia Ribes, Frederic Tort, Michio Hirano   +27 more
wiley   +1 more source

Synthesis and enzymatic evaluation of the guanosine analogue 2-amino-6-mercapto-7-methylpurine ribonucleoside (MESG): insights into the phosphorolysis reaction mechanism based on the blueprint transition state: SN1 or SN2? [PDF]

, 2010
A modified experimental procedure for the synthesis of MESG (2-amino-6-mercapto-7-methylpurine ribonucleoside) 1 has been successfully performed and its full characterization is presented.
Basso, Luiz A., Dias, Silvio L.P., Dupont, Jairton, Lapis, Alexandre A.M., Neto, Brenno A.D., Netz, Paulo A., Santos, Diógenes S., Spencer, John, Tamborim, Silvia M.   +8 more
core   +2 more sources

Inhibition and Structure of Toxoplasma gondii Purine Nucleoside Phosphorylase

Eukaryotic Cell, 2014
The intracellular pathogen Toxoplasma gondii is a purine auxotroph that relies on purine salvage for proliferation. We have optimized T. gondii purine nucleoside phosphorylase (TgPNP) stability and crystallized TgPNP with phosphate and immucillin-H, a ...
T. Donaldson, M. Cassera, M. Ho, C. Zhan, E. Merino, G. Evans, P. Tyler, S. Almo, V. Schramm, Kami Kim   +9 more
semanticscholar   +1 more source

Integrated omics revealed the altered colonic microenvironment after inhibition of peripheral serotonin synthesis by LP533401

iMetaOmics, Volume 1, Issue 2, December 2024.
The colonic microenvironment of neonatal rats was altered after administration of the peripheral 5‐hydroxytryptamine (5‐HT) inhibitor LP533401, resulting in increased crypt depth and decreased myenteric thickness. Multi‐omics approaches, including metagenomics, transcriptomics, and metabolomics, in combination with immunofluorescence, were employed to ...
Yidan Ling, Ziyu Liu, Shuibing Han, Haiqin Wu, Chunlong Mu, Weiyun Zhu   +5 more
wiley   +1 more source

Different elemental stoichiometries of Fe‐limited Trichodesmium when grown under inorganic and organic phosphorus sources

Limnology and Oceanography, Volume 69, Issue 12, Page 2881-2895, December 2024.
Abstract Trichodesmium spp. is a colonial diazotrophic cyanobacterium found in the oligotrophic (sub)tropical oceans, where its distribution is strongly regulated by the availability of phosphorus and iron. The bulk carbon : nitrogen : phosphorus elemental composition of phytoplankton has previously been shown to depart from classical “Redfield” values
Xuechao Wang, Thomas J. Browning, Eric P. Achterberg, Martha Gledhill   +3 more
wiley   +1 more source

Immunodeficiency and autoimmunity: companions not opposites

The Journal of Clinical Investigation, 2022
Autoimmunity has long been regarded as the polar opposite of immunodeficiency, but clinical and experimental evidence refute this notion. Indeed, numerous inborn or acquired immunodeficiency syndromes are characterized by the development of autoimmune ...
David A. Fox
doaj   +1 more source