Purine Nucleoside Phosphorylase from Escherichia coli and Salmonella typhimurium [PDF]
, 1975 Kaj Frank Jensen, Per Nygaard
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Computer-aided rational design of acyclovir analogs to inhibit purine nucleoside phosphorylase
Pharmaceutical and Biomedical Research, 2019 Purine nucleoside phosphorylase (PNP) is one of the major enzymes in the purine salvage pathway. It is responsible for the elevation of deoxyguanosine, and thus considered as the potent target in T-cell lymphoma.
Nusrat Jahan Selsi +9 more
doaj
BMC Cancer, 2011 Background Late stage Ovarian Cancer is essentially incurable primarily due to late diagnosis and its inherent heterogeneity. Single agent treatments are inadequate and generally lead to severe side effects at therapeutic doses.
Joshi Swapna +4 more
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Possible traces of resonance signaling in the genome [PDF]
arXiv, 2019 Although theories regarding the role of sequence-specific DNA resonance in biology have abounded for over 40 years, the published evidence for it is lacking. Here, the authors reasoned that for sustained resonance signaling, the number of oscillating DNA sequences per genome should be exceptionally high and that, therefore, genomic repeats of various ...
arxiv
Connecting Conformational Motions to Rapid Dynamics in Human Purine Nucleoside Phosphorylase. [PDF]
J Phys Chem B, 2023 Frost CF +3 more
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Control of ATP homeostasis during the respiro‐fermentative transition in yeast
Molecular Systems Biology, 2010 Respiring Saccharomyces cerevisiae cells respond to a sudden increase in glucose concentration by a pronounced drop of their adenine nucleotide content ([ATP]+[ADP]+[AMP]=[AXP]).
Thomas Walther +6 more
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Solvable models of neighbor-dependent nucleotide substitution processes [PDF]
arXiv, 2005 We prove that a wide class of models of Markov neighbor-dependent substitution processes on the integer line is solvable. This class contains some models of nucleotide substitutions recently introduced and studied empirically by molecular biologists. We show that the polynucleotide frequencies at equilibrium solve explicit finite-size linear systems ...
arxiv
The structure of His-tagged Geobacillus stearothermophilus purine nucleoside phosphorylase reveals a `spanner in the works'. [PDF]
Acta Crystallogr F Struct Biol Commun, 2022 Given FM +6 more
europepmc +1 more source
Symmetry Analysis Of Genetic Code And Determinative Degree (in Russian) [PDF]
arXiv, 2000 A three-dimensional model of the genetic vocabulary is proposed in terms of determinative degree, an introduced characteristic of nucleotide, which reflects absolute difference between purin and pyrimidin bases in one DNA strand. In the fremework of this model manifest symmetry and group properties are described. It is proposed to use the determinative
arxiv
Deoxyguanosine Triphosphate as a Possible Toxic Metabolite in the Immunodeficiency Associated with Purine Nucleoside Phosphorylase Deficiency [PDF]
, 1978 Amos Cohen +4 more
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