Targeting Purinergic Receptor P2RX1 Modulates Intestinal Microbiota and Alleviates Inflammation in Colitis [PDF]
Frontiers in Immunology, 2021 Inflammatory bowel disease (IBD) remains one of the most prevalent gastrointestinal diseases worldwide. Purinergic signaling has emerged as a promising therapeutic target of inflammation-associated diseases.
Xu Wang +8 more
doaj +3 more sources
The purinergic receptor P2X7 and the NLRP3 inflammasome are druggable host factors required for SARS-CoV-2 infection [PDF]
Frontiers in Immunology, 2023 Purinergic receptors and NOD-like receptor protein 3 (NLRP3) inflammasome regulate inflammation and viral infection, but their effects on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection remain poorly understood.
Déborah Lécuyer +58 more
doaj +3 more sources
P2 purinergic receptor dysregulation in urologic disease. [PDF]
Purinergic Signal, 2022 P2 purinergic receptors are involved in the normal function of the kidney, bladder, and prostate via signaling that occurs in response to extracellular nucleotides.
Maynard JP, Sfanos KS.
europepmc +2 more sources
Besnoitia besnoiti-induced neutrophil clustering and neutrophil extracellular trap formation depend on P2X1 purinergic receptor signaling [PDF]
Frontiers in Immunology, 2023 Bovine besnoitiosis is a re-emerging cattle disease caused by the cyst-forming apicomplexan parasite Besnoitia besnoiti. Neutrophil extracellular trap (NET) formation represents an efficient innate immune mechanism of polymorphonuclear neutrophils (PMN ...
Gabriel Espinosa +4 more
doaj +2 more sources
Purinergic receptor antagonism reduces interictal discharges and rescues cognitive function in a mouse model of temporal lobe epilepsy [PDF]
Frontiers in NeuroscienceEpilepsy is one of the most prevalent neurological disorders globally. Current treatments mainly target neuronal activity, often overlooking the involvement of astrocytes and microglia in epilepsy’s pathophysiology.
Nelson Espinosa +9 more
doaj +2 more sources
Purine and purinergic receptors in health and disease
MedComm, 2023 Purines and purinergic receptors are widely distributed throughout the human body. Purine molecules within cells play crucial roles in regulating energy metabolism and other cellular processes, while extracellular purines transmit signals through ...
Yanling Ai +6 more
doaj +2 more sources
Does Adenosine Triphosphate via Purinergic Receptor Signalling Fuel Pulmonary Fibrosis? [PDF]
Journal of Innate ImmunityBackground: Interstitial lung diseases (ILD) are poorly understood disorders characterised by diffuse damage to the lung parenchyma, with inflammation and fibrosis.
Luke Forde +6 more
doaj +2 more sources
Purinergic P2 Receptors: Novel Mediators of Mechanotransduction
Frontiers in Pharmacology, 2021 Mechanosensing and mechanotransduction are vital processes in mechanobiology and play critical roles in regulating cellular behavior and fate. There is increasing evidence that purinergic P2 receptors, members of the purinergic family, play a crucial ...
Qihang Kong +5 more
doaj +1 more source
Science Translational Medicine, 2022 Fibrosis contributes to ~45% of deaths in western countries. In chronic liver disease, fibrosis is a major factor determining outcomes, but efficient antifibrotic therapies are lacking.
I. Mederacke +21 more
semanticscholar +1 more source
P2RX1-Involved Glycolytic Metabolism Supports Neutrophil Activation in Acute Pancreatitis
Frontiers in Immunology, 2021 Acute pancreatitis (AP) is characterized by disordered inflammation of the pancreas, and the underlying mechanisms remain unclear. Purinergic signaling plays crucial roles in initiating and amplifying inflammatory signals.
Xu Wang +7 more
doaj +1 more source