Results 1 to 10 of about 2,359,528 (327)

P2 purinergic receptor dysregulation in urologic disease. [PDF]

Purinergic Signal, 2022
P2 purinergic receptors are involved in the normal function of the kidney, bladder, and prostate via signaling that occurs in response to extracellular nucleotides.
Maynard JP, Sfanos KS.
europepmc   +2 more sources

The purinergic P2Y14 receptor links hepatocyte death to hepatic stellate cell activation and fibrogenesis in the liver

Science Translational Medicine, 2022
Fibrosis contributes to ~45% of deaths in western countries. In chronic liver disease, fibrosis is a major factor determining outcomes, but efficient antifibrotic therapies are lacking.
Ingmar Mederacke, Aveline Filliol, Silvia Affò, Ajay Nair, Céline Hernandez, Qiuyan Sun, Florian Hamberger, Francesco Brundu, Yu Chen, Aashreya Ravichandra, Peter Huebener, Helena Anke, Hongxue Shi, Raquel A. Martínez García de la Torre, James R. Smith, Neil C. Henderson, Florian W. R. Vondran, Carla V. Rothlin, Heike Baehre, Ira Tabas, Pau Sancho‐Bru, Robert F. Schwabe   +21 more
openalex   +3 more sources

Small Molecules Enhance Scaffold-Based Bone Grafts via Purinergic Receptor Signaling in Stem Cells [PDF]

International Journal of Molecular Sciences, 2018
The need for bone grafts is high, due to age-related diseases, such as tumor resections, but also accidents, risky sports, and military conflicts. The gold standard for bone grafting is the use of autografts from the iliac crest, but the limited amount ...
Patrick Frank Ottensmeyer, Markus Witzler, Margit Schulze, Edda Tobiasch   +3 more
openalex   +2 more sources

Contraction of intestinal effector T cells by retinoic acid-induced purinergic receptor P2X7 [PDF]

Mucosal Immunology, 2016
The intestinal environment harbors a large number of activated T cells, which are potentially inflammatory. To prevent inflammatory responses, intestinal T cells are controlled by various tolerogenic mechanisms, including T-cell apoptosis.
Seika Hashimoto‐Hill, Leon Friesen, M. Kim, Chang H. Kim   +3 more
openalex   +2 more sources

The purinergic receptor P2X5 contributes to bone loss in experimental periodontitis

BMB Reports, 2018
Purinergic receptor signaling is increasingly recognized as an important regulator of inflammation. The P2X family purinergic receptors P2X5 and P2X7 have both been implicated in bone biology, and it has been suggested recently that P2X5 may be a ...
Hyunsoo Kim, Tetsuhiro Kajikawa, Matthew C. Walsh, Noriko Takegahara, Yun Hee Jeong, George Hajishengallis, Yongwon Choi   +6 more
openalex   +3 more sources

Purinergic receptors in airway hydration

Biochemical Pharmacology, 2021
Airway epithelial purinergic receptors control key components of the mucociliary clearance (MCC), the dominant component of pulmonary host defense. In healthy airways, the periciliary liquid (PCL) is optimally hydrated, thus acting as an efficient lubricant layer over which the mucus layer moves by ciliary force.
Eduardo R. Lazarowski, Richard C. Boucher   +1 more
openalex   +4 more sources

Purinergic Receptor [PDF]

Definitions, 2020

semanticscholar   +2 more sources

Distribution of P2Y and P2X purinergic receptor expression within the intestine.

Am J Physiol Gastrointest Liver Physiol, 2023
Engevik KA, Scribano FJ, Gebert JT, Perry JL, Crawford SE, Hyser JM.   +5 more
europepmc   +3 more sources

Hypoxia induces purinergic receptor signaling to disrupt endothelial barrier function. [PDF]

Front Physiol, 2022
Raghavan S, Brishti MA, Collier DM, Leo MD.   +3 more
europepmc   +3 more sources

Supracellular contractility in Xenopus embryo epithelia regulated by extracellular ATP and the purinergic receptor P2Y2. [PDF]

J Cell Sci
Joshi SD, Jackson TR, Zhang L, Stuckenholz C, Davidson LA.   +4 more
europepmc   +3 more sources