Results 1 to 10 of about 34,080 (142)
The purinergic receptor P2X7 and the NLRP3 inflammasome are druggable host factors required for SARS-CoV-2 infection [PDF]
Frontiers in Immunology, 2023 Purinergic receptors and NOD-like receptor protein 3 (NLRP3) inflammasome regulate inflammation and viral infection, but their effects on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection remain poorly understood.
Déborah Lécuyer +58 more
doaj +3 more sources
Besnoitia besnoiti-induced neutrophil clustering and neutrophil extracellular trap formation depend on P2X1 purinergic receptor signaling [PDF]
Frontiers in Immunology, 2023 Bovine besnoitiosis is a re-emerging cattle disease caused by the cyst-forming apicomplexan parasite Besnoitia besnoiti. Neutrophil extracellular trap (NET) formation represents an efficient innate immune mechanism of polymorphonuclear neutrophils (PMN ...
Gabriel Espinosa +4 more
doaj +2 more sources
Purinergic receptor antagonism reduces interictal discharges and rescues cognitive function in a mouse model of temporal lobe epilepsy [PDF]
Frontiers in NeuroscienceEpilepsy is one of the most prevalent neurological disorders globally. Current treatments mainly target neuronal activity, often overlooking the involvement of astrocytes and microglia in epilepsy’s pathophysiology.
Nelson Espinosa +9 more
doaj +2 more sources
Purinergic P2 Receptors: Novel Mediators of Mechanotransduction
Frontiers in Pharmacology, 2021 Mechanosensing and mechanotransduction are vital processes in mechanobiology and play critical roles in regulating cellular behavior and fate. There is increasing evidence that purinergic P2 receptors, members of the purinergic family, play a crucial ...
Qihang Kong +5 more
doaj +1 more source
P2RX1-Involved Glycolytic Metabolism Supports Neutrophil Activation in Acute Pancreatitis
Frontiers in Immunology, 2021 Acute pancreatitis (AP) is characterized by disordered inflammation of the pancreas, and the underlying mechanisms remain unclear. Purinergic signaling plays crucial roles in initiating and amplifying inflammatory signals.
Xu Wang +7 more
doaj +1 more source
Painful Purinergic Receptors [PDF]
The Journal of Pharmacology and Experimental Therapeutics, 2008 Multiple P2 receptor-mediated mechanisms exist by which ATP can alter nociceptive sensitivity following tissue injury. Evidence from a variety of experimental strategies, including genetic disruption studies and the development of selective antagonists, has indicated that the activation of P2X receptor subtypes, including P2X(3), P2X(2/3), P2X(4) and ...
Diana, Donnelly-Roberts +4 more
openaire +2 more sources
Frontiers in Immunology, 2021 Inflammatory bowel disease (IBD) remains one of the most prevalent gastrointestinal diseases worldwide. Purinergic signaling has emerged as a promising therapeutic target of inflammation-associated diseases.
Xu Wang +8 more
doaj +1 more source
Journal of Pharmaceutical Analysis, 2023 Chaigui granules (CG) are a compound composed of six herbal medicines with significant antidepressant effects. However, the antidepressant mechanism of CG remains unclear. In the present study, we attempted to elucidate the antidepressant mechanism of CG
Jiajun Chen +8 more
doaj +1 more source
Metabolic Changes Induced by Purinergic Signaling: Role in Food Intake
Frontiers in Pharmacology, 2021 The purinergic signalling has a well-established role in the regulation of energy homeostasis, but there is growing evidence of its implication in the control of food intake.
Vanni Caruso +8 more
doaj +1 more source
Frontiers in Physiology, 2023 Adenosine triphosphate (ATP) and its metabolites drive microglia migration and cytokine production by activating P2X- and P2Y- class purinergic receptors.
Byeong J. Chun +7 more
doaj +1 more source