Results 1 to 10 of about 2,325,321 (255)

The purinergic receptor P2X7 and the NLRP3 inflammasome are druggable host factors required for SARS-CoV-2 infection [PDF]

Frontiers in Immunology, 2023
Purinergic receptors and NOD-like receptor protein 3 (NLRP3) inflammasome regulate inflammation and viral infection, but their effects on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection remain poorly understood.
Déborah Lécuyer, Déborah Lécuyer, Roberta Nardacci, Roberta Nardacci, Désirée Tannous, Désirée Tannous, Désirée Tannous, Emie Gutierrez-Mateyron, Emie Gutierrez-Mateyron, Aurélia Deva Nathan, Aurélia Deva Nathan, Frédéric Subra, Cristina Di Primio, Cristina Di Primio, Paola Quaranta, Paola Quaranta, Vanessa Petit, Clémence Richetta, Ali Mostefa-Kara, Ali Mostefa-Kara, Franca Del Nonno, Laura Falasca, Romain Marlin, Pauline Maisonnasse, Julia Delahousse, Julia Delahousse, Juliette Pascaud, Juliette Pascaud, Eric Deprez, Marie Naigeon, Marie Naigeon, Marie Naigeon, Nathalie Chaput, Nathalie Chaput, Nathalie Chaput, Angelo Paci, Angelo Paci, Angelo Paci, Angelo Paci, Véronique Saada, David Ghez, David Ghez, Xavier Mariette, Xavier Mariette, Xavier Mariette, Mario Costa, Mario Costa, Mario Costa, Mauro Pistello, Mauro Pistello, Awatef Allouch, Awatef Allouch, Awatef Allouch, Olivier Delelis, Mauro Piacentini, Mauro Piacentini, Roger Le Grand, Jean-Luc Perfettini, Jean-Luc Perfettini   +58 more
doaj   +3 more sources

Besnoitia besnoiti-induced neutrophil clustering and neutrophil extracellular trap formation depend on P2X1 purinergic receptor signaling [PDF]

Frontiers in Immunology, 2023
Bovine besnoitiosis is a re-emerging cattle disease caused by the cyst-forming apicomplexan parasite Besnoitia besnoiti. Neutrophil extracellular trap (NET) formation represents an efficient innate immune mechanism of polymorphonuclear neutrophils (PMN ...
Gabriel Espinosa, Iván Conejeros, Lisbeth Rojas-Barón, Carlos Rodrigo Hermosilla, Anja Taubert   +4 more
doaj   +2 more sources

Purinergic receptor antagonism reduces interictal discharges and rescues cognitive function in a mouse model of temporal lobe epilepsy [PDF]

Frontiers in Neuroscience
Epilepsy is one of the most prevalent neurological disorders globally. Current treatments mainly target neuronal activity, often overlooking the involvement of astrocytes and microglia in epilepsy’s pathophysiology.
Nelson Espinosa, Soraya Martín-Suárez, Ariel Lara-Vasquez, Trinidad Montero, Teresa Muro-García, German Fernandez, Juan Manuel Encinas-Pérez, Juan Manuel Encinas-Pérez, Juan Manuel Encinas-Pérez, Pablo Fuentealba   +9 more
doaj   +2 more sources

Distribution of P2Y and P2X purinergic receptor expression within the intestine.

Am J Physiol Gastrointest Liver Physiol, 2023
Engevik KA, Scribano FJ, Gebert JT, Perry JL, Crawford SE, Hyser JM.   +5 more
europepmc   +3 more sources

Does Adenosine Triphosphate via Purinergic Receptor Signalling Fuel Pulmonary Fibrosis? [PDF]

Journal of Innate Immunity
Background: Interstitial lung diseases (ILD) are poorly understood disorders characterised by diffuse damage to the lung parenchyma, with inflammation and fibrosis.
Luke Forde, Debananda Gogoi, Rory Baird, Cormac McCarthy, Michael P. Keane, Emer P. Reeves, Emmet E. McGrath   +6 more
doaj   +2 more sources

Hypoxia induces purinergic receptor signaling to disrupt endothelial barrier function. [PDF]

Front Physiol, 2022
Raghavan S, Brishti MA, Collier DM, Leo MD.   +3 more
europepmc   +3 more sources

Supracellular contractility in Xenopus embryo epithelia regulated by extracellular ATP and the purinergic receptor P2Y2. [PDF]

J Cell Sci
Joshi SD, Jackson TR, Zhang L, Stuckenholz C, Davidson LA.   +4 more
europepmc   +3 more sources

Purinergic P2 Receptors: Novel Mediators of Mechanotransduction

Frontiers in Pharmacology, 2021
Mechanosensing and mechanotransduction are vital processes in mechanobiology and play critical roles in regulating cellular behavior and fate. There is increasing evidence that purinergic P2 receptors, members of the purinergic family, play a crucial ...
Qihang Kong, Yue Quan, Geer Tian, Junteng Zhou, Xiaojing Liu, Xiaojing Liu   +5 more
doaj   +1 more source

P2RX1-Involved Glycolytic Metabolism Supports Neutrophil Activation in Acute Pancreatitis

Frontiers in Immunology, 2021
Acute pancreatitis (AP) is characterized by disordered inflammation of the pancreas, and the underlying mechanisms remain unclear. Purinergic signaling plays crucial roles in initiating and amplifying inflammatory signals.
Xu Wang, Dadong Liu, Weiting Qin, Yishu Liu, Xiao Yuan, Xiaoxin Zhang, Chunhua Dai, Danyi Zhang   +7 more
doaj   +1 more source

Integrating UHPLC-MS/MS quantitative analysis and exogenous purine supplementation to elucidate the antidepressant mechanism of Chaigui granules by regulating purine metabolism

Journal of Pharmaceutical Analysis, 2023
Chaigui granules (CG) are a compound composed of six herbal medicines with significant antidepressant effects. However, the antidepressant mechanism of CG remains unclear. In the present study, we attempted to elucidate the antidepressant mechanism of CG
Jiajun Chen, Tian Li, Dehua Huang, Wenxia Gong, Junsheng Tian, Xiaoxia Gao, Xuemei Qin, Guanhua Du, Yuzhi Zhou   +8 more
doaj   +1 more source