The purinergic receptor P2X7 and the NLRP3 inflammasome are druggable host factors required for SARS-CoV-2 infection [PDF]
Frontiers in Immunology, 2023 Purinergic receptors and NOD-like receptor protein 3 (NLRP3) inflammasome regulate inflammation and viral infection, but their effects on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection remain poorly understood.
Déborah Lécuyer +58 more
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Brain Research Bulletin, 2023 Past studies have suggested that Chinese herbal may alleviate neuropathic pain, and the mechanism might target the inhibition of purinergic receptor P2.
Bo Yang, Nengwei Yu
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Besnoitia besnoiti-induced neutrophil clustering and neutrophil extracellular trap formation depend on P2X1 purinergic receptor signaling [PDF]
Frontiers in Immunology, 2023 Bovine besnoitiosis is a re-emerging cattle disease caused by the cyst-forming apicomplexan parasite Besnoitia besnoiti. Neutrophil extracellular trap (NET) formation represents an efficient innate immune mechanism of polymorphonuclear neutrophils (PMN ...
Gabriel Espinosa +4 more
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Purinergic receptor antagonism reduces interictal discharges and rescues cognitive function in a mouse model of temporal lobe epilepsy [PDF]
Frontiers in NeuroscienceEpilepsy is one of the most prevalent neurological disorders globally. Current treatments mainly target neuronal activity, often overlooking the involvement of astrocytes and microglia in epilepsy’s pathophysiology.
Nelson Espinosa +9 more
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Purinergic receptors in airway hydration
Biochemical Pharmacology, 2021 Airway epithelial purinergic receptors control key components of the mucociliary clearance (MCC), the dominant component of pulmonary host defense. In healthy airways, the periciliary liquid (PCL) is optimally hydrated, thus acting as an efficient lubricant layer over which the mucus layer moves by ciliary force.
Eduardo R. Lazarowski +1 more
openalex +3 more sources
Hypoxia induces purinergic receptor signaling to disrupt endothelial barrier function. [PDF]
Front Physiol, 2022 Raghavan S +3 more
europepmc +3 more sources
Associations Between the Purinergic Receptor P2X7 and Leprosy Disease. [PDF]
Front Genet, 2021 Souza RDC +5 more
europepmc +2 more sources
Inhibition of Galectins and the P2X7 Purinergic Receptor as a Therapeutic Approach in the Neurovascular Inflammation of Diabetic Retinopathy. [PDF]
Int J Mol Sci, 2023 Lepre CC +14 more
europepmc +3 more sources
Purinergic P2 Receptors: Novel Mediators of Mechanotransduction
Frontiers in Pharmacology, 2021 Mechanosensing and mechanotransduction are vital processes in mechanobiology and play critical roles in regulating cellular behavior and fate. There is increasing evidence that purinergic P2 receptors, members of the purinergic family, play a crucial ...
Qihang Kong +5 more
doaj +1 more source
P2RX1-Involved Glycolytic Metabolism Supports Neutrophil Activation in Acute Pancreatitis
Frontiers in Immunology, 2021 Acute pancreatitis (AP) is characterized by disordered inflammation of the pancreas, and the underlying mechanisms remain unclear. Purinergic signaling plays crucial roles in initiating and amplifying inflammatory signals.
Xu Wang +7 more
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