Results 51 to 60 of about 2,325,321 (255)

Targeting purinergic pathway to enhance radiotherapy-induced immunogenic cancer cell death

Journal of experimental & clinical cancer research : CR, 2022
Emerging evidence has demonstrated that radiotherapy (RT) can not only cause direct damage to cancer cells but also lead to immunogenic cell death (ICD), which involves the activation of host antitumor immune response in tumor immune microenvironment ...
Xuhui Bao, Liyi Xie
semanticscholar   +1 more source

Midkine‐Mediated Microglia Activation after Renal Injury Promotes Cognitive Impairment Following Ischemic Renal Injury

Advanced Science, EarlyView.
The mechanism of secondary cognitive impairment following AKI. When renal ischemic injury progresses to fibrosis, renal fibroblasts and damaged tubular cells secrete MDK, which circulates through the bloodstream, crosses the damaged BBB, and accumulates in the hippocampus tissue (an area crucial for learning and memory).
Li Lu, Bixiao Liu, Yu Yang, Tao Meng, Yuanyuan Chang, Yao Peng, Jia Guo, Zhuqing Wang, Hongqian Guo, Liuhua Zhou, Xiaozhi Zhao   +10 more
wiley   +1 more source

Purinergic Receptor Expression and Potential Association with Human Embryonic Stem Cell-Derived Oligodendrocyte Progenitor Cell Development

Cell Journal, 2017
Objective: Due to recent progress in production of human embryonic stem cell-derived oligodendrocyte progenitor cells (hESC-OPCs) for ameliorating myelin disease such as multiple sclerosis (MS) and the role of purinergic signaling in OPCs development,
Shirin Kashfi, Maryam Peymani, Kamran Ghaedi, Hossein Baharvand, Mohammad Hossein Nasr Esfahani, Mohammad Javan   +5 more
doaj   +1 more source

Endogenous Repair in Vanishing White Matter

Annals of Neurology, EarlyView.
Objective Vanishing white matter is a leukodystrophy with remarkable regional variation in disease severity. The cerebral and cerebellar white matter chronically degenerates, while stress‐induced episodes of rapid neurological deterioration coincide with the appearance of acute focal lesions in the deep gray structures and brainstem.
Bonnie C. Plug, Jodie H.K. Man, Marjolein Breur, Erik Nutma, Menno D. Stellingwerff, Truus E.M. Abbink, Marianna Bugiani, Marjo S. van der Knaap   +7 more
wiley   +1 more source

Activation of adenosine A_2B receptors enhances ciliary beat frequency in mouse lateral ventricle ependymal cells

Cerebrospinal Fluid Research, 2009
Background Ependymal cells form a protective monolayer between the brain parenchyma and cerebrospinal fluid (CSF). They possess motile cilia important for directing the flow of CSF through the ventricular system.
Ravid Katya, Yang Dan, Genzen Jonathan R, Bordey Angelique   +3 more
doaj   +1 more source

Engineering a Perfusion Bioreactor System for hiPSC‐Derived Progenitor Co‐Culture Capturing Microglial Features in CNS Development

Biotechnology and Bioengineering, EarlyView.
The authors report the development of a controlled and scalable 3D co‐culture system combining hiPSC‐derived erythromyeloid progenitors and neurospheres within the Ambr® 250 Modular platform operated with a newly designed perfusion system. This model faithfully recapitulates early microglia–neural interactions, enabling progenitor integration ...
Catarina M. Gomes, Inês de Sá, Margarida Delgado, Paula M. Alves, Catarina Brito   +4 more
wiley   +1 more source

Purinergic receptors mediate endothelial dysfunction and participate in atherosclerosis

Purinergic Signalling Purinergic Signalling, 2022
Atherosclerosis is the main pathological basis of cardiovascular disease and involves damage to vascular endothelial cells (ECs) that results in endothelial dysfunction (ED).
Xian-Ming Wu, Ning Zhang, Jiangping Li, Zhi-Hong Yang, Xiao-Lou Huang, Xiaofang Yang   +5 more
semanticscholar   +1 more source

Exosome as bioactive nanovesicle for diagnostic and therapeutic applications in periodontitis

BMEMat, EarlyView.
This review introduces the mechanism that exosomes participate in the pathogenesis of periodontitis and their potential as biomarkers for early diagnosis and summarizes the application of cell‐ or plant‐derived exosomes or engineered exosomes in periodontitis or periodontal regeneration while proposing the perspective of translational application of ...
Yu Wang, Yuchen Li, Yunfan Zhang, Chenshuang Li, Yifan Lin, Si Chen, Bing Han   +6 more
wiley   +1 more source

Biology of Platelet Purinergic Receptors and Implications for Platelet Heterogeneity

Frontiers in Pharmacology, 2018
Platelets are small anucleated cells present only in mammals. Platelets mediate intravascular hemostatic balance, prevent interstitial bleeding, and have a major role in thrombosis.
Milka Koupenova, Katya Ravid
doaj   +1 more source

P2X3 purinergic receptor overexpression is associated with poor recurrence-free survival in hepatocellular carcinoma patients

OncoTarget, 2015
P2 purinergic receptors are overexpressed in certain cancer tissues, but the pathophysiologic relevance of purinergic signaling in hepatocellular carcinoma (HCC) remains unknown.
J. Maynard, Ju-Seog Lee, B. Sohn, Xiaoying Yu, D. Lopez-Terrada, M. Finegold, J. Goss, S. Thevananther   +7 more
semanticscholar   +1 more source