Results 51 to 60 of about 2,316,796 (350)
Journal of Pharmaceutical Analysis, 2023 Chaigui granules (CG) are a compound composed of six herbal medicines with significant antidepressant effects. However, the antidepressant mechanism of CG remains unclear. In the present study, we attempted to elucidate the antidepressant mechanism of CG
Jiajun Chen +8 more
doaj
The Potential of Purinergic Signaling to Thwart Viruses Including SARS-CoV-2
Frontiers in Immunology, 2022 A long-shared evolutionary history is congruent with the multiple roles played by purinergic signaling in viral infection, replication and host responses that can assist or hinder viral functions.
Davide Ferrari +4 more
doaj +1 more source
The relationship between P2X4 and P2X7: a physiologically important interaction? [PDF]
, 2013 Purinergic signaling within the kidney is becoming an important focus in the study of renal health and disease. The effectors of ATP signaling, the P2Y and P2X receptors, are expressed to varying extents in and along the nephron.
Birch, Rebecca E +3 more
core +3 more sources
Scientific Reports, 2017 Excessive bone resorption by osteoclasts (OCs) can result in serious clinical outcomes, including bone loss that may weaken skeletal or periodontal strength.
Hyunsook Kim +6 more
semanticscholar +1 more source
Microglia modulate blood flow, neurovascular coupling, and hypoperfusion via purinergic actions
Journal of Experimental Medicine, 2022 Microglia modulate cerebral blood flow (CBF) through complex purinergic actions, which are mediated by dynamic, P2Y12 receptor-driven interactions with the vasculature. Microglial actions are partially independent of nitric oxide.
E. Császár +25 more
semanticscholar +1 more source
mBio, 2017 An exacerbated immune response is one of the main causes of influenza-induced lung damage during infection. The molecular mechanisms regulating the fate of the initial immune response to infection, either as a protective response or as detrimental ...
V. Leyva-Grado +6 more
semanticscholar +1 more source
Changes in P2Y Purinergic Receptor Expression in the Ciliary Body in a Murine Model of Glaucoma
Frontiers in Pharmacology, 2017 Glaucoma is a neuropathology, often accompanied by an elevated intraocular pressure (IOP), which can lead to blindness. Since DBA/2J mice develop glaucoma, several studies of the physiopathology of glaucoma have been reported in this animal model.
Begoña Fonseca +5 more
doaj +1 more source
Frontiers in Neuroscience, 2023 Age-related macular degeneration (AMD) is a chronic and progressive inflammatory disease of the retina characterized by photoceptor loss and significant central visual impairment due to either choroidal neovascularization or geographic atrophy.
Haydn Molcak +3 more
doaj +1 more source
Contraction of intestinal effector T cells by retinoic acid-induced purinergic receptor P2X7
Mucosal Immunology, 2016 The intestinal environment harbors a large number of activated T cells, which are potentially inflammatory. To prevent inflammatory responses, intestinal T cells are controlled by various tolerogenic mechanisms, including T-cell apoptosis.
Seika Hashimoto-Hill +3 more
semanticscholar +1 more source
Purinergic Receptors in Thrombosis and Inflammation [PDF]
Arteriosclerosis, Thrombosis, and Vascular Biology, 2015 Under various pathological conditions, including thrombosis and inflammation, extracellular nucleotide levels may increase because of both active release and passive leakage from damaged or dying cells. Once in the extracellular compartment, nucleotides interact with plasma membrane receptors belonging to the P2 purinergic family, which ...
Christian Gachet, Béatrice Hechler
openaire +3 more sources