Results 131 to 140 of about 44,593 (226)

Effects of the P2RX4 antagonist BR11595 in a guinea pig model of chronic asthma

British Journal of Pharmacology, Volume 182, Issue 21, Page 5378-5390, November 2025.
Abstract Background and Purpose Asthma is characterized by airway hyperresponsiveness (AHR), allergic inflammation, and airway remodelling. Although recent studies have shown that asthma pathophysiology involves P2X4 receptor activation, a potential link with chronic asthma remains to be explored.
Dan Li, Hoeke A. Baarsma, Melissa Mol‐van der Veen, Vicky Verschut, Kimberley S. Belfor, Tanja de Boer, Harm Maarsingh, Oliver Martin Fischer, Carolin Ebert, Hana Cernecka, Muriel Lizé, Reinoud Gosens, Loes Kistemaker, Martina Schmidt   +13 more
wiley   +1 more source

Surveilling microglia dampens neuronal activity: operation of a purinergically mediated negative feedback mechanism

Signal Transduction and Targeted Therapy, 2021
Peter Illes, Alexei Verkhratsky, Yong Tang   +2 more
doaj   +1 more source

Apoptotic Osteocytes Induce RANKL Production in Bystanders via Purinergic Signaling and Activation of Pannexin Channels [PDF]

, 2020
Sean McCutcheon, Robert J. Majeska, David C. Spray, Mitchell B. Schaffler, Maribel Vázquez   +4 more
openalex   +1 more source

Crosstalk Between Astrocytes and Inhibitory Neurons During Maturation: Emerging Mechanisms and Functional Implications

Journal of Neurochemistry, Volume 169, Issue 11, November 2025.
In this review, we discuss the development and maturation of inhibitory neurons and astrocytes and how early developmental activity in the brain might promote the interactions between these cell types. Early in development, excitatory neurons are the first to emerge.
Niina Lehti Tauriala, Vered Kellner
wiley   +1 more source

The Energetic Collapse of the Alzheimer's Brain: Metabolic Inflexibility Across Cells and Networks

Journal of Neurochemistry, Volume 169, Issue 11, November 2025.
Metabolic inflexibility in Alzheimer's disease. Schematic illustrating the biphasic trajectory of metabolic activity relative to canonical Alzheimer's disease (AD) biomarkers. In the presymptomatic phase (~15–20 years before cognitive symptoms), amyloid accumulation is accompanied by glial‐driven hypermetabolism, reflecting early metabolic ...
Nicholas J. Constantino, Clair C. Ashley, Shannon L. Macauley   +2 more
wiley   +1 more source

Mitochondria Are Gate-keepers of T Cell Function by Producing the ATP That Drives Purinergic Signaling [PDF]

, 2014
Carola Ledderose, Yi Bao, Markus Lidicky, Johannes Zipperle, Lin Li, Katharina Strasser, Nathan I. Shapiro, Wolfgang G. Junger   +7 more
openalex   +1 more source

Pathogenesis of ureteral dysfunction and compensatory mechanisms of small stone passage: the role of purinergic signaling

, 2022
Э.Ф. Баринов, Ю.Ю. Малинин, Х.В. Григорян   +2 more
openalex   +2 more sources

Biglycan : a multivalent proteoglycan providing structure and signals [PDF]

, 2013
Research over the past few years has provided fascinating results indicating that biglycan, besides being a ubiquitous structural component of the extracellular matrix (ECM), may act as a signaling molecule.
Năstase, Mădălina-Viviana, Schäfer, Liliana, Young, Marian F.   +2 more
core  

Comparative analysis of androgen and estrogen receptor mRNA expression in adult mouse hippocampus

Journal of Neuroendocrinology, Volume 37, Issue 11, November 2025.
Abstract In hippocampus, androgens and estrogens influence neuronal plasticity via a range of nuclear or membrane‐bound receptors. While much work has focused on determining their functions, a certain vagueness about the cellular expression of established receptors has remained.
Malte Schöbe, Bianka Brunne, Roland A. Bender   +2 more
wiley   +1 more source

The bumpy road of purinergic inhibitors to clinical application in immune-mediated diseases

Neural Regeneration Research
Purinergic signaling plays important roles throughout the body in the regulation of organ functions during and following the disruption of homeostasis. This is also reflected by the widespread expression of two families of purinergic receptors (P1 and P2)
Matthias T Wyss, Christine Heuer, Marina Herwerth   +2 more
doaj   +1 more source