Strain-induced mechanotransduction through primary cilia, extracellular ATP, purinergic calcium signaling, and ERK1/2 transactivates CITED2 and downregulates MMP-1 and MMP-13 gene expression in chondrocytes [PDF]
, 2015 Zhiyong He +8 more
openalex +1 more source
Piezo2 in Mechanosensory Biology: From Physiological Homeostasis to Disease‐Promoting Mechanisms
Cell Proliferation, Volume 59, Issue 1, January 2026.Piezo2 channels are essential mechanotransducers regulating touch, proprioception and visceral mechanosensation across physiological systems, emerging as therapeutic targets for pathological mechanical hypersensitivity and neurogenic disorders. ABSTRACT Piezo2, a mechanically activated ion channel, serves as the key molecular transducer for touch ...
Zhebin Cheng +4 more
wiley +1 more source
ATPγS Enhances the Production of Inflammatory Mediators by a Human Dermal Endothelial Cell Line via Purinergic Receptor Signaling [PDF]
, 2006 Kristina Seiffert +3 more
openalex +1 more source
Microglial- and Astrocyte-Specific Expression of Purinergic Signaling Components and Inflammatory Mediators in the Rat Hippocampus During Trimethyltin-Induced Neurodegeneration [PDF]
, 2021 Milorad Dragić +4 more
openalex +1 more source
Connexin26 and 43 play a role in regulating pro-inflammatory events in the epidermis [PDF]
, 2019 Bartholomew, Christopher +4 more
core +1 more source
IL‐6 in the spotlight: From cardiovascular pathophysiology to therapy
European Journal of Clinical Investigation, Volume 56, Issue 1, January 2026.Interleukin‐6 (IL‐6) links inflammation to cardiovascular and multi‐organ dysfunction. This review integrates mechanistic, translational, and clinical evidence supporting IL‐6 as both a biomarker and therapeutic target in the continuum of cardiovascular and cardio‐renal disease.
Alberto Preda +13 more
wiley +1 more source
Oxytocinergic Signaling in Zebrafish: Translational Perspectives for Autism Spectrum Disorder
Journal of Neurochemistry, Volume 170, Issue 1, January 2026.Alterations in oxytocin signaling are strongly implicated in the social and cognitive deficits characterizing Autism Spectrum Disorder (ASD) and other neurodevelopmental conditions. However, the precise mechanisms remain unclear. The zebrafish (Danio rerio) has emerged as a powerful translational model due to its evolutionarily conserved oxytocin ...
Géssica Peres +3 more
wiley +1 more source
Development of the neurohypophysis: A major neuroendocrine interface
Journal of Neuroendocrinology, Volume 38, Issue 1, January 2026.Abstract The neurohypophysis is a major central neuroendocrine interface regulating reproductive functions and water homeostasis. Distinct neurovascular cell types interact via evolutionarily conserved signaling molecules in the developing neurohypophysis, providing a model system for studying principles in neuroendocrine interface morphogenesis.
Athul R. Ramesh +5 more
wiley +1 more source