Results 171 to 180 of about 4,625,876 (321)
Potential therapeutic targets in the rapidly expanding field of purinergic signalling [PDF]
, 2002 Geoffrey Burnstock
openalex +1 more source
Sphingosine‐1‐phosphate activates LRRC8 volume‐regulated anion channels through Gβγ signalling
The Journal of Physiology, EarlyView.Abstract figure legend Sphingosine‐1‐phosphate (S1P) binds to Gi protein‐coupled receptor S1PR1. Upon S1PR1 activation, Gβγ is released from the Gαi‐Gβγ heterotrimer, allowing it to recruit phospholipase Cβ (PLCβ) to the plasma membrane. PLCβ cleaves phosphatidylinositol‐4,5‐bisphosphate (PIP2) into inositol trisphosphate (IP3) and diacylglycerol (DAG).
Yulia Kostritskaia +4 more
wiley +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend Epidemiological evidence suggests a link between dementia and cardiovascular health, including the regulation of platelets. To investigate this relationship, we examined how platelet reactivity relates to cerebral neurovascular function and systemic vascular reactivity in healthy older adults.
Gabriella M. K. Rossetti +10 more
wiley +1 more source
Spatio-temporal propagation of Ca2+ signals by cyclic ADP-ribose in 3T3 cells stimulated via purinergic P2Y receptors [PDF]
, 2003 Santina Bruzzone +4 more
openalex +1 more source
Purinergic signaling in the modulation of redox biology
Redox Biology, 2021 L. Savio +4 more
semanticscholar +1 more source
Editorial: Purinergic Signaling and Inflammation [PDF]
Frontiers in Immunology, 2021 Davide Ferrari +8 more
openaire +4 more sources
Targeting Connexin 43 in Retinal Astrocytes Promotes Neuronal Survival in Glaucomatous Injury
Glia, Volume 73, Issue 7, Page 1398-1419, July 2025.Main Points Astrocytes play an important role in glaucoma. These cells express Cx43 which can form gap junctions and hemichannels. This study shows Cx43 deletion in astrocytes provides neuroprotection in glaucoma, possibly through hemichannel activation.
Khulan Batsuuri +4 more
wiley +1 more source
Purinergic signaling: a potential therapeutic target for depression and chronic pain
Purinergic Signalling Purinergic Signalling, 2021 Yuting Zou +4 more
semanticscholar +1 more source
Potassium‐Dependent Coupling of Retinal Astrocyte Light Response to Müller Glia
Glia, Volume 73, Issue 7, Page 1520-1534, July 2025.Main Points Astrocytes depolarize to light ON and OFF like Müller glia. The astrocyte light response is due to potassium influx. Retinal macroglial current‐voltage responses exhibit rectification which changes with repeated stimulation. ABSTRACT Astrocytes throughout the central nervous system mediate a variety of functions to support proper tissue ...
Joseph Matthew Holden +3 more
wiley +1 more source
Muscle &Nerve, Volume 72, Issue 1, Page 15-33, July 2025.ABSTRACT Regeneration after peripheral nerve injury is often insufficient for functional recovery. Postoperative electrical stimulation (PES) following injury and repair significantly improves clinical outcomes; recently, conditioning electrical stimulation (CES), delivered before nerve injury, has been introduced as a candidate for clinical ...
Paige B. Hardy +4 more
wiley +1 more source