Results 11 to 20 of about 4,625,876 (321)
Glial Purinergic Signaling in Neurodegeneration [PDF]
Frontiers in Neurology, 2021 Purinergic signaling regulates neuronal and glial cell functions in the healthy CNS. In neurodegenerative diseases, purinergic signaling becomes dysregulated and can affect disease-associated phenotypes of glial cells. In this review, we discuss how cell-
Marie J. Pietrowski +9 more
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Purinergic signaling: Diverse effects and therapeutic potential in cancer. [PDF]
Front Oncol, 2023 Regardless of improved biological insights and therapeutic advances, cancer is consuming multiple lives worldwide. Cancer is a complex disease with diverse cellular, metabolic, and physiological parameters as its hallmarks.
Kaur J, Dora S.
europepmc +3 more sources
Frontiers in Molecular Neuroscience, 2022 Trigeminal ganglion (TG) is the first station of sensory pathways in the orofacial region. The TG neurons communicate with satellite glial cells (SGCs), macrophages and other cells forming a functional unit that is responsible for processing of orofacial
Shilin Jia +10 more
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Purinergic signaling in the male reproductive tract. [PDF]
Front Endocrinol (Lausanne), 2022 Purinergic receptors are ubiquitously expressed throughout the body and they participate in the autocrine and paracrine regulation of cell function during normal physiological and pathophysiological conditions.
Belardin LB +4 more
europepmc +3 more sources
Purinergic Signaling in Spermatogenesis. [PDF]
Front Endocrinol (Lausanne), 2022 Adenosine triphosphate (ATP) serves as the essential source of cellular energy. Over the last two decades, however, ATP has also attracted increasing interest as an extracellular signal that activates purinergic plasma membrane receptors of the P2 family.
Mundt N, Kenzler L, Spehr M.
europepmc +5 more sources
Purinergic signaling: A gatekeeper of blood-brain barrier permeation. [PDF]
Front Pharmacol, 2023 This review outlined evidence that purinergic signaling is involved in the modulation of blood-brain barrier (BBB) permeability. The functional and structural integrity of the BBB is critical for maintaining the homeostasis of the brain microenvironment.
Wang Y +6 more
europepmc +3 more sources
Emerging roles of purinergic signaling in anti-cancer therapy resistance
Frontiers in Cell and Developmental Biology, 2022 Cancer is a complex disease with a rapid growing incidence and often characterized by a poor prognosis. Although impressive advances have been made in cancer treatments, resistance to therapy remains a critical obstacle for the improvement of patients ...
Michele Zanoni +3 more
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Purinergic Signaling and Related Biomarkers in Depression
Brain Sciences, 2020 It is established that purinergic signaling can shape a wide range of physiological functions, including neurotransmission and neuromodulation. The purinergic system may play a role in the pathophysiology of mood disorders, influencing neurotransmitter ...
Francesco Bartoli +3 more
doaj +2 more sources
Purinergic Signaling in Bone [PDF]
Journal of Osteoporosis, 2013 In recent years, it has become apparent that extracellular nucleotides, signalling via P2 receptors, play an important role in the regulation of bone turnover. Furthermore, purinergic signalling has been associated in the pathophysiology of several bone and cartilage diseases, including osteoarthritis, rheumatoid arthritis, and osteoporosis and might ...
Niklas Rye Jørgensen +3 more
doaj +4 more sources
Purinergic Signaling in the Hallmarks of Cancer [PDF]
Cells, 2020 Cancer is a complex expression of an altered state of cellular differentiation associated with severe clinical repercussions. The effort to characterize this pathological entity to understand its underlying mechanisms and visualize potential therapeutic ...
A. Campos-Contreras +2 more
semanticscholar +5 more sources