Results 11 to 20 of about 22,737 (199)

Purinergic and Adenosinergic Signaling in Pancreatobiliary Diseases

Frontiers in Physiology, 2022
Adenosine 5'-triphosphate (ATP), other nucleotides, and the nucleoside analogue, adenosine, all have the capacity to modulate cellular signaling pathways.
Erika Y. Faraoni, Cynthia Ju, Simon C. Robson, Holger K. Eltzschig, Jennifer M. Bailey-Lundberg   +4 more
doaj   +1 more source

Single-cell RNA sequencing reveals distinct transcriptional features of the purinergic signaling in mouse trigeminal ganglion

Frontiers in Molecular Neuroscience, 2022
Trigeminal ganglion (TG) is the first station of sensory pathways in the orofacial region. The TG neurons communicate with satellite glial cells (SGCs), macrophages and other cells forming a functional unit that is responsible for processing of orofacial
Shilin Jia, Shilin Jia, JinYue Liu, JinYue Liu, Yanhao Chu, Yanhao Chu, Qing Liu, Lijia Mai, Lijia Mai, Wenguo Fan, Wenguo Fan   +10 more
doaj   +1 more source

P2RX1-Involved Glycolytic Metabolism Supports Neutrophil Activation in Acute Pancreatitis

Frontiers in Immunology, 2021
Acute pancreatitis (AP) is characterized by disordered inflammation of the pancreas, and the underlying mechanisms remain unclear. Purinergic signaling plays crucial roles in initiating and amplifying inflammatory signals.
Xu Wang, Dadong Liu, Weiting Qin, Yishu Liu, Xiao Yuan, Xiaoxin Zhang, Chunhua Dai, Danyi Zhang   +7 more
doaj   +1 more source

ATP indirectly stimulates hippocampal CA1 and CA3 pyramidal neurons via the activation of neighboring P2X7 receptor-bearing astrocytes and NG2 glial cells, respectively

Frontiers in Pharmacology, 2022
There is ongoing dispute on the question whether CNS neurons possess ATP-sensitive P2X7 receptors (Rs) or whether only non-neuronal cells bear this receptor-type and indirectly signal to the neighboring neurons. We genetically deleted P2X7Rs specifically
Ying Zhang, Hai-Yan Yin, Patrizia Rubini, Patrizia Rubini, Peter Illes, Peter Illes, Peter Illes, Yong Tang, Yong Tang, Yong Tang   +9 more
doaj   +1 more source

Purinergic signaling via P2X receptors and mechanisms of unregulated ATP release in the outer retina and age-related macular degeneration

Frontiers in Neuroscience, 2023
Age-related macular degeneration (AMD) is a chronic and progressive inflammatory disease of the retina characterized by photoceptor loss and significant central visual impairment due to either choroidal neovascularization or geographic atrophy.
Haydn Molcak, Kailun Jiang, Christopher J. Campbell, Joanne A. Matsubara   +3 more
doaj   +1 more source

The Role of Microglial Purinergic Receptors in Pain Signaling

Molecules, 2022
Pain is an essential modality of sensation in the body. Purinergic signaling plays an important role in nociceptive pain transmission, under both physiological and pathophysiological conditions, and is important for communication between both neuronal ...
Hidetoshi Tozaki-Saitoh, Hiroshi Takeda, Kazuhide Inoue   +2 more
doaj   +1 more source

A companion to the preclinical common data elements and case report forms for neuropathology studies in epilepsy research. A report of the TASK3 WG2 Neuropathology Working Group of the ILAE/AES Joint Translational Task Force

Epilepsia Open, EarlyView., 2022
Abstract The International League Against Epilepsy/American Epilepsy Society (ILAE/AES) Joint Translational Task Force initiated the TASK3 working group to create common data elements (CDEs) for various aspects of preclinical epilepsy research studies, which could help improve the standardization of experimental designs.
Eleonora Aronica, Devin K. Binder, Meinrad Drexel, Chrysanthy Ikonomidou, Shilpa D. Kadam, Guenther Sperk, Christian Steinhäuser   +6 more
wiley   +1 more source

The Role of Purinergic Signaling in Heart Transplantation

Frontiers in Immunology, 2022
Heart transplantation remains the optimal treatment option for patients with end-stage heart disease. Growing evidence demonstrates that purinergic signals mediated by purine nucleotides and nucleosides play vital roles in heart transplantation ...
Yanzhi Jiang, Jianxin Lin, Haiyun Zheng, Ping Zhu   +3 more
doaj   +1 more source

Mitochondria Synergize With P2 Receptors to Regulate Human T Cell Function

Frontiers in Immunology, 2020
Intracellular ATP is the universal energy carrier that fuels many cellular processes. However, immune cells can also release a portion of their ATP into the extracellular space.
Carola Ledderose, Wolfgang G. Junger
doaj   +1 more source

Purine and purinergic receptors in health and disease

MedComm, 2023
Purines and purinergic receptors are widely distributed throughout the human body. Purine molecules within cells play crucial roles in regulating energy metabolism and other cellular processes, while extracellular purines transmit signals through ...
Yanling Ai, Hengyi Wang, Lu Liu, Yulin Qi, Shiyun Tang, Jianyuan Tang, Nianzhi Chen   +6 more
doaj   +1 more source