Results 21 to 30 of about 44,593 (226)

Deficiency of the purinergic receptor 2X7 attenuates nonalcoholic steatohepatitis induced by high-fat diet. possible role of the NLRP3 Inflammasome [PDF]

, 2017
Molecular mechanisms driving transition from simple steatosis to nonalcoholic steatohepatitis (NASH), a critical step in the progression of nonalcoholic fatty liver disease (NAFLD) to cirrhosis, are poorly defined. This study aimed at investigating the
Blasetti Fantauzzi, Claudia, Iacobini, Carla, Menini, Stefano, Pugliese, Giuseppe, Rossi, Chiara, Santini, Eleonora, Solini, Anna   +6 more
core   +3 more sources

Purinergic signaling in schistosomal infection

Biomedical Journal, 2016
Human schistosomiasis is a chronic inflammatory disease caused by blood fluke worms belonging to the genus Schistosoma. Health metrics indicate that the disease is related to an elevated number of years lost-to-disability and years lost-to-life ...
Claudia Lucia Martins Silva
doaj   +1 more source

Purinergic Signaling and Related Biomarkers in Depression

Brain Sciences, 2020
It is established that purinergic signaling can shape a wide range of physiological functions, including neurotransmission and neuromodulation. The purinergic system may play a role in the pathophysiology of mood disorders, influencing neurotransmitter ...
Francesco Bartoli, Geoffrey Burnstock, Cristina Crocamo, Giuseppe Carrà   +3 more
doaj   +1 more source

The Potential of Purinergic Signaling to Thwart Viruses Including SARS-CoV-2

Frontiers in Immunology, 2022
A long-shared evolutionary history is congruent with the multiple roles played by purinergic signaling in viral infection, replication and host responses that can assist or hinder viral functions.
Davide Ferrari, Davide Ferrari, Michele Rubini, Jorge S. Burns, Jorge S. Burns   +4 more
doaj   +1 more source

Purinergic signaling in infection and autoimmune disease

Biomedical Journal, 2016
Purinergic signaling plays a key role in inflammatory processes and modulates immune responses against a variety of bacterial and eukaryotic parasites.
Luiz Eduardo Baggio Savio, Robson Coutinho-Silva   +1 more
doaj   +1 more source

Besnoitia besnoiti-induced neutrophil clustering and neutrophil extracellular trap formation depend on P2X1 purinergic receptor signaling

Frontiers in Immunology, 2023
Bovine besnoitiosis is a re-emerging cattle disease caused by the cyst-forming apicomplexan parasite Besnoitia besnoiti. Neutrophil extracellular trap (NET) formation represents an efficient innate immune mechanism of polymorphonuclear neutrophils (PMN ...
Gabriel Espinosa, Iván Conejeros, Lisbeth Rojas-Barón, Carlos Rodrigo Hermosilla, Anja Taubert   +4 more
doaj   +1 more source

Extracellular ATP drives systemic inflammation, tissue damage and mortality [PDF]

, 2014
Systemic inflammatory response syndromes (SIRS) may be caused by both infectious and sterile insults, such as trauma, ischemia-reperfusion or burns. They are characterized by early excessive inflammatory cytokine production and the endogenous release of ...
Brouckaert, Peter, Cauwels, Anje, Rogge, Elke, Shiva, S, Vandendriessche, Benjamin   +4 more
core   +1 more source

Purinergic signaling and purine base metabolism at the crossroads between immunity, metabolism, and cancer: A review

ImmunoMedicine, 2023
In addition to its universally known role in transferring genetic material, DNA nucleotides and nucleosides are regarded as the most ancient form of extracellular signaling molecules. This unique signaling pathway was first reported by Dr.
Delaney K. Geitgey, Anja J. Melendez, Raquel Caldeira‐Botelho, Melissa L. Kemp, Curtis J. Henry   +4 more
doaj   +1 more source

Purinergic Signaling in Pathologic Osteogenic Differentiation of Aortic Valve Interstitial Cells from Patients with Aortic Valve Calcification

Biomedicines, 2023
Purinergic signaling is associated with a vast spectrum of physiological processes, including cardiovascular system function and, in particular, its pathological calcifications, such as aortic valve stenosis.
Polina Klauzen, Daria Semenova, Daria Kostina, Vladimir Uspenskiy, Anna Malashicheva   +4 more
doaj   +1 more source

Toll-Like Receptor 4 Modulates Small Intestine Neuromuscular Function through Nitrergic and Purinergic Pathways [PDF]

, 2017
Objective: Toll-like receptors (TLRs) play a pivotal role in the homeostatic microflora-host crosstalk. TLR4-mediated modulation of both motility and enteric neuronal survival has been reported mainly for colon with limited information on the role of ...
Cecilia Giulivi, Cecilia Giulivi, Eleonora Napoli, Francesca Galuppini, Genny Orso, Ilaria Marsilio, Isabella Lante, Maria Cecilia Giron, Massimo Rugge, Mona Roozfarakh, Silvia Cerantola, Silvia Cerantola, Valentina Caputi   +12 more
core   +3 more sources