Results 21 to 30 of about 4,625,876 (321)
The Role of Microglial Purinergic Receptors in Pain Signaling
Molecules, 2022 Pain is an essential modality of sensation in the body. Purinergic signaling plays an important role in nociceptive pain transmission, under both physiological and pathophysiological conditions, and is important for communication between both neuronal ...
Hidetoshi Tozaki-Saitoh +2 more
doaj +2 more sources
Purinergic Signaling in the Pathophysiology and Treatment of Huntington’s Disease
Frontiers in Neuroscience, 2021 Huntington’s disease (HD) is a devastating, progressive, and fatal neurodegenerative disorder inherited in an autosomal dominant manner. This condition is characterized by motor dysfunction (chorea in the early stage, followed by bradykinesia, dystonia ...
Melissa Talita Wiprich +4 more
doaj +2 more sources
Purinergic Signaling in Pulmonary Inflammation [PDF]
Frontiers in Immunology, 2019 Purine nucleotides and nucleosides are at the center of biologic reactions. In particular, adenosine triphosphate (ATP) is the fundamental energy currency of cellular activity and adenosine has been demonstrated to play essential roles in human ...
Thanh-Thuy T. Le +5 more
semanticscholar +5 more sources
Purinergic signaling in schistosomal infection
Biomedical Journal, 2016 Human schistosomiasis is a chronic inflammatory disease caused by blood fluke worms belonging to the genus Schistosoma. Health metrics indicate that the disease is related to an elevated number of years lost-to-disability and years lost-to-life ...
Claudia Lucia Martins Silva
doaj +4 more sources
SARS-CoV-2 Spike protein alters microglial purinergic signaling. [PDF]
Front Immunol, 2023 Despite long-term sequelae of COVID-19 are emerging as a substantial public health concern, the mechanism underlying these processes still unclear. Evidence demonstrates that SARS-CoV-2 Spike protein can reach different brain regions, irrespective of ...
Alves VS +15 more
europepmc +2 more sources
Purinergic Signaling in Neuroinflammation [PDF]
International Journal of Molecular Sciences, 2021 ATP is stored in millimolar concentrations within the intracellular medium but may be released to extracellular sites either through the damaged plasma membrane or by means of various transporters [...]
Dmitry Aminin, Peter Illes
openaire +2 more sources
Purinergic signaling: a potential therapeutic target for ischemic stroke. [PDF]
Purinergic Signal, 2023 Wang L +9 more
europepmc +2 more sources
Purinergic signaling in myocardial ischemia-reperfusion injury. [PDF]
Purinergic Signal, 2023 Zhuang Y, Yu ML, Lu SF.
europepmc +2 more sources
Purinergic and Adenosinergic Signaling in Pancreatobiliary Diseases
Frontiers in Physiology, 2022 Adenosine 5'-triphosphate (ATP), other nucleotides, and the nucleoside analogue, adenosine, all have the capacity to modulate cellular signaling pathways.
Erika Y. Faraoni +4 more
doaj +1 more source
Nature Communications, 2022 How the glioma immune microenvironment fosters tumorigenesis remains incompletely defined. Here, we use single-cell RNA-sequencing and multiplexed tissue-imaging to characterize the composition, spatial organization, and clinical significance of ...
S. Coy +22 more
semanticscholar +1 more source