Results 101 to 110 of about 7,462 (180)

Effects of the P2RX4 antagonist BR11595 in a guinea pig model of chronic asthma

British Journal of Pharmacology, Volume 182, Issue 21, Page 5378-5390, November 2025.
Abstract Background and Purpose Asthma is characterized by airway hyperresponsiveness (AHR), allergic inflammation, and airway remodelling. Although recent studies have shown that asthma pathophysiology involves P2X4 receptor activation, a potential link with chronic asthma remains to be explored.
Dan Li, Hoeke A. Baarsma, Melissa Mol‐van der Veen, Vicky Verschut, Kimberley S. Belfor, Tanja de Boer, Harm Maarsingh, Oliver Martin Fischer, Carolin Ebert, Hana Cernecka, Muriel Lizé, Reinoud Gosens, Loes Kistemaker, Martina Schmidt   +13 more
wiley   +1 more source

Crosstalk Between Astrocytes and Inhibitory Neurons During Maturation: Emerging Mechanisms and Functional Implications

Journal of Neurochemistry, Volume 169, Issue 11, November 2025.
In this review, we discuss the development and maturation of inhibitory neurons and astrocytes and how early developmental activity in the brain might promote the interactions between these cell types. Early in development, excitatory neurons are the first to emerge.
Niina Lehti Tauriala, Vered Kellner
wiley   +1 more source

A Novel Catalytically Inactive Construct of Botulinum Neurotoxin A (BoNT/A) Directly Inhibits Visceral Sensory Signalling

Toxins
Botulinum neurotoxin A (BoNT/A) is a potent neurotoxin that silences cholinergic neurotransmission through the cleavage of the synaptic protein SNAP-25.
Hodan Ibrahim, Kevin Retailleau, Fraser Hornby, Jacquie Maignel, Matthew Beard, Donna Marie Daly   +5 more
doaj   +1 more source

MicroRNA: Crucial modulator in purinergic signalling involved diseases. [PDF]

Purinergic Signal, 2023
Guo J, Yang P, Li YF, Tang JF, He ZX, Yu SG, Yin HY.   +6 more
europepmc   +1 more source

Trichomoniasis immunity and the involvement of the purinergic signaling

, 2016
Camila Braz Menezes, Tiana Tasca
openalex   +1 more source

Mitochondria Are Gate-keepers of T Cell Function by Producing the ATP That Drives Purinergic Signaling [PDF]

, 2014
Carola Ledderose, Yi Bao, Markus Lidicky, Johannes Zipperle, Lin Li, Katharina Strasser, Nathan I. Shapiro, Wolfgang G. Junger   +7 more
openalex   +1 more source

Pathogenesis of ureteral dysfunction and compensatory mechanisms of small stone passage: the role of purinergic signaling

, 2022
Э.Ф. Баринов, Ю.Ю. Малинин, Х.В. Григорян   +2 more
openalex   +2 more sources

The Energetic Collapse of the Alzheimer's Brain: Metabolic Inflexibility Across Cells and Networks

Journal of Neurochemistry, Volume 169, Issue 11, November 2025.
Metabolic inflexibility in Alzheimer's disease. Schematic illustrating the biphasic trajectory of metabolic activity relative to canonical Alzheimer's disease (AD) biomarkers. In the presymptomatic phase (~15–20 years before cognitive symptoms), amyloid accumulation is accompanied by glial‐driven hypermetabolism, reflecting early metabolic ...
Nicholas J. Constantino, Clair C. Ashley, Shannon L. Macauley   +2 more
wiley   +1 more source

EROS is a selective chaperone regulating the phagocyte NADPH oxidase and purinergic signalling. [PDF]

Elife, 2022
Randzavola LO, Mortimer PM, Garside E, Dufficy ER, Schejtman A, Roumelioti G, Yu L, Pardo M, Spirohn K, Tolley C, Brandt C, Harcourt K, Nichols E, Nahorski M, Woods G, Williamson JC, Suresh S, Sowerby JM, Matsumoto M, Santos CXC, Kiar CS, Mukhopadhyay S, Rae WM, Dougan GJ, Grainger J, Lehner PJ, Calderwood MA, Choudhary J, Clare S, Speak A, Santilli G, Bateman A, Smith KGC, Magnani F, Thomas DC.   +34 more
europepmc   +1 more source

Purinergic Receptors Crosstalk with CCR5 to Amplify Ca2+ Signaling [PDF]

, 2020
Mizuho Horioka, Emilie Ceraudo, Emily Lorenzen, Thomas P. Sakmar, Thomas Huber   +4 more
openalex   +1 more source