Results 101 to 110 of about 4,754,967 (333)

Exosome as bioactive nanovesicle for diagnostic and therapeutic applications in periodontitis

BMEMat, EarlyView.
This review introduces the mechanism that exosomes participate in the pathogenesis of periodontitis and their potential as biomarkers for early diagnosis and summarizes the application of cell‐ or plant‐derived exosomes or engineered exosomes in periodontitis or periodontal regeneration while proposing the perspective of translational application of ...
Yu Wang, Yuchen Li, Yunfan Zhang, Chenshuang Li, Yifan Lin, Si Chen, Bing Han   +6 more
wiley   +1 more source

A polycystin-type transient receptor potential (Trp) channel that is activated by ATP

Biology Open, 2017
ATP and ADP are ancient extra-cellular signalling molecules that in Dictyostelium amoebae cause rapid, transient increases in cytosolic calcium due to an influx through the plasma membrane.
David Traynor, Robert R. Kay
doaj   +1 more source

Membrane compartments and purinergic signalling [PDF]

The FEBS Journal, 2008
Evolution has led to efficient cooperation between processes at the cellular level. This embodies the combinatorial complexity of transferring information through nucleic acids and proteins, and information processing that involves the diffusion of primary ligands and ⁄or second messengers.
Barth K, Volonté C
openaire   +4 more sources

Mesenchymal stem cells from tumor microenvironment favour breast cancer stem cell proliferation, cancerogenic and metastatic potential, via ionotropic purinergic signalling

Scientific Reports, 2017
Interaction between tumor cells and the microenvironment is key in initiation, progression, and invasiveness of cancer. In particular, mesenchymal stem cells (MSCs) are recruited to the sites of developing tumors, thus promoting metastasis formation ...
A. Maffey, C. Storini, C. Diceglie, C. Martelli, L. Sironi, C. Calzarossa, N. Tonna, R. Lovchik, E. Delamarche, L. Ottobrini, L. Ottobrini, F. Bianco   +11 more
semanticscholar   +1 more source

Physiological Electrical Signals Promote Chain Migration of Neuroblasts by Up-Regulating P2Y1 Purinergic Receptors and Enhancing Cell Adhesion [PDF]

, 2014
Acknowledgments This work was supported by a grant from NHS Grampian. Open Access This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the ...
Cao, Lin, Ching, Jared, McCaig, Colin D, Pu, Jin, Scott, Roderick H   +4 more
core   +2 more sources

Enhancing antitumor immunity through the combination of cholesterolized TLR7 agonist liposomes and radiotherapy: a role for IL‐1β and the inflammasome pathway

Cancer Communications, EarlyView.
Abstract Background Radiotherapy (RT) is a key treatment modality in cancer therapy, utilizing high‐energy radiation to directly kill tumor cells. Recent research has increasingly highlighted RT's potential to indirectly enhance antitumor immunity. However, this immune activation alone often fails to generate sustained systemic antitumor responses.
Xuejiao Han, Yuan Cheng, Dandan Wan, Aqu Alu, Ziqi Zhang, Zhenfei Bi, Manni Wang, Yan Tang, Weiqi Hong, Siyuan Chen, Li Chen, Yuquan Wei   +11 more
wiley   +1 more source

An emerging role for adenosine and its receptors in bone homeostasis

Frontiers in Endocrinology, 2012
Bone is continually being remodelled and defects in the processes involved lead to bone diseases. Many regulatory factors are known to influence remodelling but other mechanisms, hitherto unknown, may also be involved.
Bronwen eEvans, Bronwen eEvans, Jack eHam, Jack eHam   +3 more
doaj   +1 more source

Signaling of the Purinergic System in the Joint [PDF]

Frontiers in Pharmacology, 2020
The joint is a complex anatomical structure consisting of different tissues, each with a particular feature, playing together to give mobility and stability at the body. All the joints have a similar composition including cartilage for reducing the friction of the movement and protecting the underlying bone, a synovial membrane that produces synovial ...
Carmen Corciulo, Carmen Corciulo, Bruce N. Cronstein, Bruce N. Cronstein   +3 more
openaire   +4 more sources

Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues

ESC Heart Failure, Volume 12, Issue 2, Page 1059-1080, April 2025.
Abstract Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left ventricular diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac ...
Zhuyubing Fang, Umar Raza, Jia Song, Junyan Lu, Shun Yao, Xiaohong Liu, Wei Zhang, Shujuan Li   +7 more
wiley   +1 more source

Purinergic signaling microenvironments: An introduction [PDF]

Purinergic Signalling, 2008
The common theme of this introductory article and the minireviews that follow in this special issue is the concept of microenvironments within tissues and surrounding cells that would be ideal signaling venues for a biologically active purinergic ligand.
J. Gregory Fitz, Erik M. Schwiebert
openaire   +3 more sources