Results 121 to 130 of about 4,754,967 (333)
Astroglial CB1 Reveal Sex‐Specific Synaptic Effects of Amphetamine
Glia, EarlyView.Astroglial CB1R mediates long‐term synaptic plasticity (LTD) in the Nucleus accumbens. Amphetamine saturates adenosine receptors and blocks LTD in males, but not females. Locomotor effects of amphetamine require astroglial CB1R in males, but not in females.
Yamuna Mariani +15 more
wiley +1 more source
Modelling Underwater Acoustic Propagation using One-way Wave Equations [PDF]
arXiv, 2022 The primary contribution of this paper is to characterize the propagation of acoustic signal carrying information through any medium and the interaction of the travelling acoustic signal with the surrounding medium. We will use the concept of damped harmonic oscillator to model the medium and Milne's oscillator technique to map the interaction of the ...
arxiv
Neuroprotection, EarlyView.Mechanistic crosstalk between microglia and astrocytes in major depressive disorder. Abstract Major depressive disorder (MDD) is a complex psychiatric condition increasingly linked to chronic neuroinflammation, particularly in the context of aging, stress, and systemic comorbidities.
Gaurav Singhal +2 more
wiley +1 more source
Purinergic Signalling in Inflammatory Renal Disease
Frontiers in Physiology, 2013 Extracellular purines have a role in renal physiology and adaption to inflammation. However, inflammatory renal disease may be mediated by extracellular purines, resulting in renal injury.
Nishkantha eArulkumaran +6 more
doaj +1 more source
Towards bandwidth estimation for graph signal reconstruction [PDF]
arXiv, 2023 In numerous graph signal processing applications, data is often missing for a variety of reasons, and predicting the missing data is essential. In this paper, we consider data on graphs modeled as bandlimited graph signals. Predicting or reconstructing the unknown signal values for such a model requires an estimate of the signal bandwidth.
arxiv
Regional differences in store-operated Ca2+ entry in the epithelium of the intact human lens [PDF]
, 2009 An elevated level of Ca2+ is an important factor in cataract, yet precisely how Ca2+ enters the lens is unknown. Lens epithelial cells contain a range of G-protein–coupled receptors and receptor tyrosine kinases that induce increases in intracellular Ca2+
Duncan, George +4 more
core +1 more source
A Xanthine Derivative With Novel Heat Shock Protein 90‐Alpha Inhibitory and Senolytic Properties
Aging Cell, EarlyView.This study aimed to find safe senolytic drugs that selectively eliminate senescent cells. Focusing on HSP90 inhibitors, we employed a virtual screening to identify novel, safer compounds (A). K5, a xanthinic candidate, effectively eliminated senescent cells in various cellular models (B), extended lifespan in flies, and reduced aging signs in mice (C).
Sandra Atlante +24 more
wiley +1 more source
ATP Hysteresis in Tripartite Synapses [PDF]
arXiv, 2009 Recent experimental studies strongly suggest the influence of glial purinergic transmission in the modulation of synaptic dynamics. By releasing adenosine triphosphate (ATP), which accumulates as adenosine, astrocytes tonically suppressed synaptic transmission. The delayed multi-step feedback of the glial adenosine with the neuron suggest the existence
arxiv
Low-Complexity Signal Detection for the Splitting Receiver Scheme [PDF]
arXiv, 2023 This letter proposes a low-complexity signal detection method for the splitting receiver scheme, which achieves an excellent symbol error rate (SER) performance. Based on the three-dimensional (3D) received signal of the splitting receiver, we derive an equivalent two-dimensional (2D) signal model and develop a low-complexity signal detection method ...
arxiv
Aging Cell, EarlyView.This study shows that human and mouse brains contain a different pool of strains that differentially affect the formation of Aβ and tau aggregates. Moreover, the murine seeds trigger an unresponsiveness microglial state, which causes the loss of plaque microglial coverage and affects the formation of amyloid plaques, leading to more severe neuritic ...
Juana Andreo‐Lopez +20 more
wiley +1 more source