Results 1 to 10 of about 38,381 (252)

Relative Stability of Pyrazinamide Polymorphs Revisited: A Computational Study of Bending and Brittle Forms Phase Transitions in a Broad Temperature Range [PDF]

Crystals, 2023
Pyrazinamide may exist in at least four known polymorphic forms, which were obtained experimentally. One of these polymorphs, (α), shows outstanding mechanical properties, demonstrating a significant anisotropic plasticity in a three-point bending test ...
Aleksandr S. Dubok, Denis A. Rychkov
doaj   +2 more sources

Pyrazinamide resistance in rifampicin discordant tuberculosis.

PLoS ONE, 2022
IntroductionMycobacterium tuberculosis strains with phenotypically susceptible rpoB mutations (rifampicin discordant) have emerged following implementation of rapid molecular drug resistance testing for tuberculosis. Whilst rifampicin resistance is known
Nomonde Ritta Mvelase, Ravesh Singh, Khine Swe Swe-Han, Koleka Patience Mlisana   +3 more
doaj   +2 more sources

Diagnosis and Interim Treatment Outcomes from the First Cohort of Multidrug-Resistant Tuberculosis Patients in Tanzania. [PDF]

, 2013
Kibong'oto National Tuberculosis Hospital (KNTH), Kilimanjaro, Tanzania. Characterize the diagnostic process and interim treatment outcomes from patients treated for multidrug-resistant tuberculosis (MDR-TB) in Tanzania.
Boeree, Martin J, Gratz, Jean, Heysell, Scott K, Houpt, Eric R, Kibiki, Gibson S, Kisonga, Riziki M, Kumburu, Happiness H, Lekule, Isack A, Mpagama, Stellah G, Ndusilo, Nora D   +9 more
core   +15 more sources

Prevalence and Clinical Implications of Pyrazinamide Resistance in Newly Diagnosed TB Patients in Uganda. [PDF]

Infect Drug Resist
Ndawula C, Petra NP, Wasswa FB, Bazira J.   +3 more
europepmc   +3 more sources

Pyrazinamide clearance is impaired among HIV/tuberculosis patients with high levels of systemic immune activation. [PDF]

PLoS ONE, 2017
Pyrazinamide is the main driver of sterilizing effect in the standard regimen in adults and older children, and this effect is concentration-dependent. Tuberculosis patients co-infected with human immunodeficiency virus (HIV) have an increased risk for ...
Christopher Vinnard, Shruthi Ravimohan, Neo Tamuhla, Jotam Pasipanodya, Shashikant Srivastava, Chawangwa Modongo, Nicola M Zetola, Drew Weissman, Tawanda Gumbo, Gregory P Bisson   +9 more
doaj   +1 more source

Correlations among the plasma concentrations of first-line anti-tuberculosis drugs and the physiological parameters influencing concentrations

Frontiers in Pharmacology, 2023
Background: The plasma concentrations of the four most commonly used first-line anti-tuberculosis (TB) drugs, isoniazid (INH), rifampicin (RMP), ethambutol (EMB), and pyrazinamide (PZA), are often not within the therapeutic range.
Lin Cheng, Ming Luo, Yan Guo, Yunfan Fan, Pengsen Wang, Gang Zhou, Shiwei Qin, Bangbi Weng, Peibo Li, Zhirui Liu, Songtao Liu   +10 more
doaj   +1 more source

Structure-Aware Mycobacterium tuberculosis Functional Annotation Uncloaks Resistance, Metabolic, and Virulence Genes

mSystems, 2021
Accurate and timely functional genome annotation is essential for translating basic pathogen research into clinically impactful advances. Here, through literature curation and structure-function inference, we systematically update the functional genome ...
Samuel J. Modlin, Afif Elghraoui, Deepika Gunasekaran, Alyssa M. Zlotnicki, Nicholas A. Dillon, Nermeeta Dhillon, Norman Kuo, Cassidy Robinhold, Carmela K. Chan, Anthony D. Baughn, Faramarz Valafar   +10 more
doaj   +1 more source

Pyrazinamide Induced Polyarthralgia and Myalgia in a Case of Pulmonary Tuberculosis – A Case Report [PDF]

Journal of Krishna Institute of Medical Sciences University, 2021
Pyrazinamide Induced polyarthralgia is common but myalgia is an uncommon adverse drug reaction. Understanding a case with estimated peak plasma concentration correlation is very rarely performed.
Bijoy Kumar Panda, Vaibhav Rajendra Suryawanshi, Aksa Thomas, Medha Bargaje, Sathiyanarayanan L   +4 more
doaj  

Value of pyrazinamide for composition of new treatment regimens for multidrug-resistant Mycobacterium tuberculosis in China

BMC Infectious Diseases, 2020
Background Pyrazinamide still may be a useful drug for treatment of rifampin-resistant (RR-TB) or multidrug-resistant tuberculosis (MDR-TB) in China while awaiting scale up of new drugs and regimens including bedaquiline and linezolid.
Hui Xia, Susan van den Hof, Frank Cobelens, Yang Zhou, Bing Zhao, Shengfen Wang, Yanlin Zhao   +6 more
doaj   +1 more source

Metallochaperones Are Needed for Mycobacterium tuberculosis and Escherichia coli Nicotinamidase-Pyrazinamidase Activity. [PDF]

, 2020
Mycobacterium tuberculosis nicotinamidase-pyrazinamidase (PZAse) is a metalloenzyme that catalyzes conversion of nicotinamide-pyrazinamide to nicotinic acid-pyrazinoic acid. This study investigated whether a metallochaperone is required for optimal PZAse
Antiparra, R, Arteaga, H, Bueno, C, Campos, J, Duran, P, Gilman, RH, Huerta, R, Kirwan, DE, Monsalve, A, Sheen, P, Zimic, M   +10 more
core   +1 more source