Results 61 to 70 of about 35,915 (205)

Improving Genotype Imputation in High‐Dimensional Pharmacogenomics Using Multiple Imputation: Evaluation with Machine Learning Approaches

Clinical Pharmacology &Therapeutics, Volume 119, Issue 4, Page 964-978, April 2026.
Multiple imputation is well‐established for handling missing data, yet its use in high‐dimensional genetic datasets remains limited. Using pharmacokinetic tuberculosis simulations and SNP data (1000 Genomes Project), we compared machine learning (ML) and traditional approaches (e.g., mean imputation and complete‐case analysis) for imputation and ...
Innocent G. Asiimwe, Tao You, Daniel F. Carr, Munir Pirmohamed, Geraint Davies, Andrea L. Jorgensen, on behalf of the UNITE4TB Consortium   +6 more
wiley   +1 more source

Role of Nigella Sativa Seeds on Pyrazinamide Induced Hepatotoxicity

Journal of Islamic International Medical College, 2019
Objective: To determine the hepatoprotective effect of Nigella sativa seeds in Pyrazinamide induced hepatic damage in albino mice. Study Design: An experimental study.
Amtul Hafeez , Akbar Waheed , Neelofar Yousaf
doaj  

Synthesis of Novel Pyrazinamide Derivatives Based on 3-Chloropyrazine-2-carboxamide and Their Antimicrobial Evaluation

Molecules, 2017
Aminodehalogenation of 3-chloropyrazine-2-carboxamide with variously substituted benzylamines yielded a series of fifteen 3-benzylaminopyrazine-2-carboxamides. Four compounds possessed in vitro whole cell activity against Mycobacterium tuberculosis H37Rv
Ondrej Jandourek, Marek Tauchman, Pavla Paterova, Klara Konecna, Lucie Navratilova, Vladimir Kubicek, Ondrej Holas, Jan Zitko, Martin Dolezal   +8 more
doaj   +1 more source

Surface Plasmon Resonance‐based Biosensing Towards the Detection of Multidrug‐Resistant Tuberculosis

Advanced Photonics Research, Volume 7, Issue 3, March 2026.
This study presents the detection of multidrug‐resistant tuberculosis (MDR‐TB) gene targets (InhA, KatG, and RpoB) and their mutations using a surface plasmon resonance (SPR)‐based biosensing platform to monitor target binding on functionalized sensor chips.
Sipho H. Chauke, Lerato Hlekelele, Charles Maphanga, Mabotse Tjale, Felix S. Dube, Saturnin Ombinda‐Lemboumba, Patience Mthunzi‐Kufa   +6 more
wiley   +1 more source

‘ZS-MDR-TB’ versus ‘ZR-MDR-TB’: improving treatment of MDR-TB by identifying pyrazinamide susceptibility

Emerging Microbes and Infections, 2012
Indispensable for shortening treatment of drug-susceptible tuberculosis (TB), pyrazinamide (PZA, Z) is also essential in the treatment of multidrug-resistant (MDR)-TB. While resistance to PZA in MDR-TB is associated with poor treatment outcome, bacillary
Ying Zhang, Kwok Chiu Chang, Chi-Chiu Leung, Wing Wai Yew, Brigitte Gicquel, Dorothy Fallows, Gilla Kaplan, Richard E Chaisson, Wenhong Zhang   +8 more
doaj   +1 more source

5-Alkylamino-N-phenylpyrazine-2-carboxamides: Design, Preparation, and Antimycobacterial Evaluation

Molecules, 2020
According to the World Health Organization, tuberculosis is still in the top ten causes of death from a single infectious agent, killing more than 1.7 million people worldwide each year.
Weronika Ambrożkiewicz, Marta Kučerová-Chlupáčová, Ondřej Janďourek, Klára Konečná, Pavla Paterová, Pavel Bárta, Jarmila Vinšová, Martin Doležal, Jan Zitko   +8 more
doaj   +1 more source

Atypical Presentation of Pediatric Spinal Tuberculosis as Chronic Abdominal Pain: A Case Report

Clinical Case Reports, Volume 14, Issue 3, March 2026.
ABSTRACT Spinal tuberculosis, also known as Pott's disease, in children is a rare manifestation of extrapulmonary tuberculosis. The nonspecific clinical features, such as chronic abdominal pain, of extrapulmonary TB or spinal TB in children tend to delay diagnosis.
Bilal Aslam, Faiza Farooq, Shafiq Ur Rahman, Fazeela Bibi, Umama Alam, Okasha Tahir, Adil Nawaz, Jibran Ikram   +7 more
wiley   +1 more source

Pyrazinamide resistance-conferring mutations in pncA and the transmission of multidrug resistant TB in Georgia. [PDF]

, 2017
BACKGROUND: The ongoing epidemic of multidrug-resistant tuberculosis (MDR-TB) in Georgia highlights the need for more effective control strategies.
Anthony, Richard M, Bergval, Indra L, Clark, Taane G, de Beer, Jessica L, de Zwaan, Rina, Phelan, Jody, Schuitema, Anja R, Sengstake, Sarah, van Soolingen, Dick   +8 more
core   +4 more sources

Primary Pericardial Angiosarcoma Demonstrating Initial Response Followed by Progression on First‐Line Chemotherapy: A Case Report

Clinical Case Reports, Volume 14, Issue 3, March 2026.
ABSTRACT Primary pericardial angiosarcoma is an exceedingly rare and highly aggressive malignancy arising from pericardial endothelial cells, with a reported median survival of approximately 7 months. Owing to its non‐specific clinical presentation, diagnosis is frequently delayed, particularly in tuberculosis‐endemic regions, where symptoms may be ...
Ujjwal Kumar Thakur, Akash Subedi, Rheecha Joshi, Sunita Dhanchha, Sumit Yadav, Binaya Pangyani, Ajaya Acharya, Punam KC, Sunil Shrestha, Gerim Prasai, Abish Adhikari, Anjani Kumar Jha, Subhas Pandit, Simit Sapkota   +13 more
wiley   +1 more source

Paediatric Acute Generalised and Localised Exanthematous Pustulosis: A Systematic Review

JEADV Clinical Practice, EarlyView.
Miranda K. Branyiczky, Megan Lowe, Eric McMullen, Shireen Dumont, Narachai Julanon, Vincent Piguet, Cathryn Sibbald   +6 more
wiley   +1 more source