Unraveling Lignin's Color Puzzle: From Chromophore Origins to Advanced Decolorization Strategies
Aggregate, Volume 7, Issue 1, January 2026.This review provides a comprehensive systematic analysis of the research advancements in lignin color formation mechanisms and decolorization techniques, specifically focusing on three principal approaches: hydroxyl shielding, biomass fractionation, and physical methods. It highlights the systematic research approach of the review toward decolorization
Lizhen Huang, Zhuotong Wu, Li Shuai
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A Proteochemometric Model for Ligands of the SLC5 Transporter Family
Archiv der Pharmazie, Volume 359, Issue 1, January 2026.A novel proteochemometric model was developed to predict the activity and selectivity of SLC5 family inhibitors. The model's performance was validated using 10‐fold cross‐validation on publicly available datasets achieving Q2 = 0.79 and MSE < 0.32. Detailed analysis of the results enabled the identification of a new, previously unrecognized selectivity‐
Martin Juhás, Gerhard Ecker
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Discovery of New Pyrazole‐Tosylamide Derivatives as Apoptosis Inducers Through BCL‐2 Inhibition and Caspase‐3 Activation [PDF]
Burak Kuzu, Ege Arzuk
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Crystal structure of 1-(2,6-dichloro-4-(trifluoromethyl)phenyl)-5-((3-bromophenyl) methyleneimino)-1H-pyrazole-3-carbonitrile, C18H8BrCl2F3N4 [PDF]
, 2006 X.-G. Zhang, X.-H. Zhang, Ping Zhong
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ChemistryEurope, Volume 4, Issue 1, January 2026.This Perspective focuses on photocatalyst‐free, photoinduced modifications of biomolecules, emphasizing transformations mediated by electron donor–acceptor complexes. Mechanistic aspects, current limitations, and future opportunities are discussed, providing insight into the field of bioconjugation.
Milene Hornink +3 more
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Searching for Novel Antiviral Agents as COVID19 Treatments: Guanidino Diaryl Thioureas
ChemMedChem, Volume 21, Issue 1, January 2026.Structure of the "hit‐compound" found and the proposed interaction with the active site of the TMPRSS2 protease, involving a reversible mechanism of action, are shown. The COVID‐19 pandemic highlighted the urgent need for effective antiviral treatments targeting SARS‐CoV‐2.
Marco Minneci +6 more
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Customizing Native Chemical Ligation: A Case Study on Histone Variant H2A.B from Toolbox to Target
Chemistry–Methods, Volume 6, Issue 1, January 2026.The core histone protein variant H2A.B, chosen as the target protein, is involved in many transcriptional processes regulated by its post‐translational modifications. Herein, the native chemical toolbox is harnessed to demonstrate the successful synthesis and semi‐synthesis of site‐specifically modified H2A.B variants via different strategies.
Tobias Gökler +4 more
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PharmaceuticalsIn this innovative research, we aim to reveal pyrazole-based Schiff bases as new multi-target agents. In this context, we re-synthesized three sets of pyrazole-based Schiff bases, 5a–f, 6a–f, and 7a–f, to evaluate their biological applications.
Ahmed M. Naglah +6 more
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Celecoxib Derivatives Containing Pyrazole Linked‐Sulfonamide Moiety: Carbonic Anhydrase I–II and Acetylcholinesterase Inhibition Profiles, Molecular Docking Studies [PDF]
, 2023 Serpil Gerni +4 more
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