Results 101 to 110 of about 19,589 (195)

G9a inhibition reduces stress‐potentiated alcohol drinking in both male and female mice: Implications for safe and effective pharmacological therapeutics for alcohol use disorder

Alcohol, Clinical and Experimental Research, Volume 50, Issue 3, March 2026.
Targeting stress‐escalated alcohol drinking could help patients with alcohol use disorder (AUD). We found that reducing the activity of the epigenetic regulatory enzyme G9a (aka euchromatic histone‐lysine N‐methyltransferase 2 or EHMT2) by repeated systemic administration of a G9a inhibitor reduces stress‐escalated ethanol drinking in a mouse model ...
Deltrice Holmes, Marcelo F. Lopez, Howard C. Becker, Christopher W. Cowan, Ethan M. Anderson   +4 more
wiley   +1 more source

Pyrazole [PDF]

, 2020
openaire   +1 more source

Multi-targeted pyrazole scaffolds: synthesis, mechanistic insights, and therapeutic potential in anticancer, antioxidant, and anti-inflammatory applications. [PDF]

Libyan J Med
Aljameel SS, Eissa ME, Alatawi Z, Alahmadi HA, Azab ME, Yousef TA, Ramadan SK, Aljohi HA, Al-Farraj ES, Bahattab EA, Ghareeb A, El-Helw EAE.   +11 more
europepmc   +1 more source

Development of new pyrazole-thiophene hybrids: synthesis, anticancer assessment, and molecular docking insights. [PDF]

RSC Adv
Samy S, Mahmoud SE, Abdel-Galil E, Abdel-Latif E, Said GE.   +4 more
europepmc   +1 more source

Efficient Access to Functionalized <i>N</i>‑Difluoromethylpyrazoles. [PDF]

ACS Omega
Ugrak B, Dutova T, Rusak V, Xia D, Tretyakov E.   +4 more
europepmc   +1 more source

Derivatives of 1-(2-Pyridyl)-3-pyrazolecarboxylic Acids as Ligands for Binding f-Elements. [PDF]

Molecules
Abramova OI, Ivanov AV, Borisova NE, Bitanova VA, Lyssenko KA, Kharcheva AV, Patsaeva SV.   +6 more
europepmc   +1 more source

Prenatal alcohol exposure induces anxiety and depressive-like behaviors with deficits in growth and food intake in mice. [PDF]

Front Cell Dev Biol
Smimih K, El-Mansoury B, Marghich M, Azzouhri C, Zouhairi N, Agnaou M, Guennouni M, Fdil N, Bitar A, Abulmeaty MMA, Aldisi D, Oudat Q, Aboul-Soud MAM, Merzouki M, El Hiba O.   +14 more
europepmc   +1 more source

Human Liver Alcohol Dehydrogenase: Inhibition by Pyrazole and Pyrazole Analogs. [PDF]

Acta Chemica Scandinavica, 1969
Ting-Kai Li, Hugo Theorell, Charles Larsen, Per Halfdan Nielsen, Alf A. Lindberg, Gert Jansen, Bo Lamm, Benny Samuelsson   +7 more
openaire   +2 more sources

Cyclometalated Ir(iii) complexes bridged by µ-OH and µ-3,5-bis(4-methoxyphenyl)-pyrazole ligands. [PDF]

RSC Adv
Mausami, Trivedi H, Patra R, Behere RP, Kuila B, Singh Patel SK, Pandey MD, Maiti B, Mahanti B.   +8 more
europepmc   +1 more source

Biocatalyzed aza-michael addition <i>via</i> continuous flow technology: a game-changer for the facile synthesis of <i>N-</i>alkylated pyrazole derivatives. [PDF]

RSC Adv
Du LH, Yan BL, Xue MM, Wang L, Luo XP.
europepmc   +1 more source