Results 101 to 110 of about 42,319 (209)

Induction of Peroxisomal β‐Oxidation as a Critical Mechanism for Ethanol‐Induced Hepatic Triglyceride Accumulation

FASEB BioAdvances, EarlyView.
Prolonged fasting and fibrate treatment induce peroxisomal β‐oxidation and lead to excessive generation of hydrogen peroxide, which stimulates ethanol metabolism and significantly increases the formation of acetaldehyde; further oxidation of acetaldehyde into acetate remarkably elevates the mitochondrial ratio of NADH/NAD+ and causes feedback ...
Yida Zhang, Wei Zhang, Yicong Li, Haoya Yao, Yaoqing Wang, Xiao Zhang, Jia Zeng   +6 more
wiley   +1 more source

Computation screening for incorrectly determined cocrystal structures

Acta Crystallographica Section B, Volume 81, Issue 2, Page 208-216, April 2025.
Computational salt–cocrystal differentiation, based on density functional theory improved by up‐to‐date functionals rSCAN and r2SCAN, has been tested for 404 structures. Several problematic structures have been redetermined.Pharmaceutical solid forms, like salts and cocrystals, play a crucial role in drug formulation.
Simona Chalupná, Michal Hušák, Jan Čejka, František Fňukal, Jiří Klimeš   +4 more
wiley   +1 more source

Increased alcohol‐biased choice behavior in mouse models of high alcohol drinking

Alcohol, Clinical and Experimental Research, EarlyView.
Mice that experienced chronic intermittent ethanol (CIE) exposure or CIE and forced swim stress (FSS) showed increased voluntary alcohol intake. In two separate studies, presentation of sucrose as an alternative reward reduced alcohol intake more readily in control mice compared with CIE and CIE + FSS groups.
Marcelo F. Lopez, Howard C. Becker
wiley   +1 more source

Dual‐Responsive Phosphorus‐Based Fluorescent Sensors: Synthesis and Selective Metal Sensing of Pyrazolyl Phosphine Oxides

Angewandte Chemie, Volume 137, Issue 23, June 2, 2025.
Pyrazolyl phosphine oxides are shown to act as dual‐responsive fluorescent sensors, displaying a selective “turn‐off” fluorescence response for Fe3+ and a “turn‐on” response for Al3+. These systems serve as a new framework in the field of sensing materials based on main‐group elements such as phosphorus. Abstract Despite a wealth of previously reported
Ethan D. E. Calder, Isobel R. J. Hawes, Andrew R. Jupp   +2 more
wiley   +2 more sources

Folding, misfolding, and regulation of intracellular traffic of G protein‐coupled receptors involved in the hypothalamic–pituitary–gonadal axis

Andrology, EarlyView.
Abstract Background G protein‐coupled receptors are a large and functionally diverse family of membrane receptors involved in a number of biological processes. Like other proteins, G protein‐coupled receptors need to be properly folded in order to traffic to the plasma membrane and interact with agonist.
Alfredo Ulloa‐Aguirre, Ross C. Anderson, Teresa Zariñán, Rubén Gutiérrez‐Sagal, Eduardo Jardón‐Valadez, Claire L. Newton   +5 more
wiley   +1 more source

Sex differences in the vasoactive effect of transient receptor potential channels: TRPM3 as a new therapeutic target for (neuro)vascular disorders

British Journal of Pharmacology, Volume 182, Issue 11, Page 2503-2523, June 2025.
Abstract Background and Purpose Sex‐dependent vascular effects of transient receptor potential (TRP) channels and sex dimorphism in migraine are not yet fully characterized. We investigated the differential vasoactive effects of TRP ankyrin 1 (TRPA1), TRP melastatin 3 (TRPM3) and TRP vanilloid 1 (TRPV1) channels, their pharmacological mechanism(s), and
Eduardo Rivera‐Mancilla, Usha M. Musterd‐Bhaggoe, Dennis Schutter, Antoon van den Bogaerdt, Arnaud J. P. E. Vincent, Carlos M. Villalón, Alexander H. J. Danser, Antoinette MaassenVanDenBrink   +7 more
wiley   +1 more source

Human Liver Alcohol Dehydrogenase: Inhibition by Pyrazole and Pyrazole Analogs. [PDF]

Acta Chemica Scandinavica, 1969
Ting-Kai Li, Hugo Theorell, Charles Larsen, Per Halfdan Nielsen, Alf A. Lindberg, Gert Jansen, Bo Lamm, Benny Samuelsson   +7 more
openaire   +3 more sources

Elucidating the Role and Mechanism of Alpha‐Enolase in Senescent Amelioration via Metabolic Reprogramming

Cell Proliferation, EarlyView.
KB2764 interacted with alpha‐enolase (ENO1) and pyruvate kinase M (PKM), ultimately leading to PKM phosphorylation of ENO1. KB2764 consequently increased mitochondrial ATP production and decreased glycolysis dependence. Furthermore, the action of KB2764 extends its application to extend the lifespan of Caenorhabditis elegans.
Yun Haeng Lee, Hyunwoong Lim, Gyungmin Kim, Geonhee Jang, Myeong Uk Kuk, Ji Ho Park, Jee hee Yoon, Yoo Jin Lee, Duyeol Kim, Byeonghyeon So, Minseon Kim, Hyung Wook Kwon, Youngjoo Byun, Joon Tae Park   +13 more
wiley   +1 more source

Therapeutic targeting of TGF‐β in lung cancer

The FEBS Journal, Volume 292, Issue 7, Page 1520-1557, April 2025.
Here, we discuss how lung cancer treatment can be transformed by targeting TGF‐β for better outcomes. Inhibiting TGF‐β signaling halts tumor growth, boosts immune response, and enhances treatment efficacy. By tackling TGF‐β's role in epithelial–mesenchymal transition (EMT) and immune evasion, this approach opens new avenues for more effective lung ...
Sajjad Aftabi, Amir Barzegar Behrooz, Marco Cordani, Niloufar Rahiman, Mohammadamin Sadeghdoust, Farnaz Aligolighasemabadi, Stephen Pistorius, Seyedeh Hoda Alavizadeh, Nima Taefehshokr, Saeid Ghavami   +9 more
wiley   +1 more source

Structure–activity analysis of imino‐pyrimidinone‐fused pyrrolidines aids the development of dual plasmepsin V and plasmepsin X inhibitors

The FEBS Journal, EarlyView.
Compounds were identified that inhibit the aspartic protease plasmepsin V from Plasmodium vivax. Further development of these compounds identified compounds, such as S‐WM48, that could inhibit both plasmepsin V and plasmepsin X but plasmepsin IX was not significantly inhibited.
Anthony N. Hodder, Brad E. Sleebs, Greg Adams, Sina Rezazadeh, Anna Ngo, Kate Jarman, Stephen Scally, Peter Czabotar, Hongwu Wang, John A. McCauley, David B. Olsen, Alan F. Cowman   +11 more
wiley   +1 more source