Endohedral Coordination of Bulky Substrates in Metalloenzyme‐Like Organometallic Nanotubes
Chemistry – A European Journal, Volume 31, Issue 30, May 27, 2025.An organometallic nanotube with eight CuI ions mimics metalloenzyme behavior, featuring a flexible pore, metal‐ligand substrate binding, and redox‐active metals. Insertion of THF as a model substrate is driven by coordination, as confirmed by SC‐XRD, NMR, and DFT.
Thomas Pickl +7 more
wiley +1 more source
Medicinal Chemistry Strategies in Targeting TGF-βR1 Kinase Domain: Unveiling Insights into Inhibitor Structure-Activity Relationship (SAR). [PDF]
Pharmaceuticals (Basel)Babiker NA +5 more
europepmc +1 more source
Five-membered heterocycles as promising platforms for molecular logic gate construction. [PDF]
RSC AdvCiupa A.
europepmc +1 more source
European Journal of Organic Chemistry, Volume 28, Issue 18, May 23, 2025.A straightforward method for the synthesis of alkyl enol ethers was developed, based upon microwave‐promoted alkyne hydroalkoxylation, requiring only alkyne and alcohol components and mild base catalysis. The reaction displayed broad substrate tolerance and was highly selective for Z‐configured, anti‐Markovnikov enol ether products.
Owaen Guppy, Alexis Perry
wiley +1 more source
Microwave Assisted Synthesis of Antioxidant Dihydro-Pyrazole Hybrids as Possible Lipoxygenase Inhibitors. [PDF]
MoleculesPeitzika SC, Tsiampakari E, Pontiki E.
europepmc +1 more source
Heterometallic Coordination Compounds with Amino‐Acid Dithiocarbamate Ligands
European Journal of Inorganic Chemistry, Volume 28, Issue 13, May 21, 2025.This comprehensive review surveys the synthesis, molecular structures, and properties of heterobimetallic coordination compounds with amino‐acid dithiocarbamate ligands (AA‐DTCs), important O,S‐ditopic ligands. Most of the known compounds form infinite assemblies of different dimensions rather than molecular entities in the solid state.
Phil Köhler
wiley +1 more source
In Vitro Enzymatic and Computational Assessments of Pyrazole-Isatin and Pyrazole-Indole Conjugates as Anti-Diabetic, Anti-Arthritic, and Anti-Inflammatory Agents. [PDF]
PharmaceuticsNaglah AM +6 more
europepmc +1 more source
Exploring Bioinspired Ln3+ Complexes for Cu2+ Detection: Design and Efficacy as MRI Contrast Agents
European Journal of Inorganic Chemistry, Volume 28, Issue 13, May 21, 2025.Gd3+ complexes bearing a bioinspired Cu2+‐binding site derived from ATCUN are studied as MRI contrast agents. The presence of two amino acids (GH) is necessary to bind Cu2+ and trigger a relaxivity increase. This is due to a higher number of H2O retained close to Gd3+ through H‐bonding with Cu2+. Remarkably, the system remains selective for Cu2+ vs Zn2+
Martina Sanadar +7 more
wiley +1 more source
Unraveling aromaticity: the dual worlds of pyrazole, pyrazoline, and 3D carborane. [PDF]
Beilstein J Org ChemNoori Z +4 more
europepmc +1 more source
Chemistry – A European Journal, Volume 31, Issue 28, May 19, 2025.Radical processes involving bismuth hold great potential, but innovative strategies are required to control the reactivity of bismuth intermediates. Herein, we report a direct photochemical decarboxylation with molecular bismuth for C─N coupling of benzylic carboxylic acids and sulfonamides.
Elina K. Taskinen +3 more
wiley +1 more source