Results 131 to 140 of about 42,319 (209)

Revision of the Formycin A and Pyrazofurin Biosynthetic Pathways Reveals Specificity for d-Glutamic Acid and a Cryptic <i>N</i>-Acylation Step During Pyrazole Core Formation. [PDF]

J Am Chem Soc
Zheng Z, Ren D, Ko Y, Liu HW.
europepmc   +1 more source

Design and Evaluation of Bivalent K‐Ras Inhibitors That Target the CAAX Binding Site and the Acidic Surface of Farnesyltransferase and Geranylgeranyltransferase I

Chemistry – A European Journal, Volume 31, Issue 27, May 14, 2025.
Chemical inhibition of K‐Ras posttranslational prenylation represents a promising strategy against aggressive cancers. A structure‐based design produces piperidine‐based peptidomimetics conjugated to cationic modules, effectively inhibiting FTase and GGTase I at single‐digit nanomolar concentrations.
Naomi Horiuchi, Rania Omer, Fumitoshi Sugino, Nanami Ogino, Yoshihisa Inoue, Kazi Aslamuzzaman, Takeyuki Suzuki, Said M. Sebti, Junko Ohkanda   +8 more
wiley   +1 more source

Design, Synthesis, and Characterization of Novel Pyrazole Cross-Linked Chitosan Derivatives Modified with Zinc Oxide Nanoparticles for Boosting Their Anticancer Activity. [PDF]

Polymers (Basel)
Almutairi HD, Abdel-Motaal M, Sharaky M, Mohamed NA.   +3 more
europepmc   +1 more source

Design and Synthesis of Tetrahydropyrrolo[3,4‐c]Pyrazole Sigma‐1 Receptor Ligands

ChemMedChem, Volume 20, Issue 9, May 5, 2025.
This study highlights the tetrahydropyrrolo[3,4‐c]pyrazole scaffold as a promising platform for S1R ligands development. Key findings include compound 19’s high S1R affinity (Ki=75 nM), influenced by strategic nitrogen substitutions and reduced steric hindrance.
Giuseppe Cosentino, Maria Dichiara, Giuliana Costanzo, Alessandro Coco, Lorella Pasquinucci, Agostino Marrazzo, Antonio Rescifina, Emanuele Amata   +7 more
wiley   +1 more source

Design, synthesis, and investigation of novel 5-arylpyrazole-glucose hybrids as α-glucosidase inhibitors. [PDF]

Sci Rep
Hariri R, Saeedi M, Mojtabavi S, Alizadeh S, Ebadi A, Faramarzi MA, Amini M, Sharifzadeh M, Biglar M, Akbarzadeh T.   +9 more
europepmc   +1 more source

Synthesis, molecular docking, assessment of biological and anti-diabetic properties of benzalacetophenone derivatives. [PDF]

Sci Rep
Shehab WS, Elhoseni NKR, Aboulthana WM, Assy MG, Mousa SM, El-Bassyouni GT.   +5 more
europepmc   +1 more source

The Role of Flow Chemistry on the Synthesis of Pyrazoles, Pyrazolines and Pyrazole-Fused Scaffolds. [PDF]

Molecules
Correia CM, Silva AMS, Silva VLM.
europepmc   +1 more source

Antifungal activity and biocompatibility assessment with molecular docking and dynamic simulations of new pyrazole derivatives. [PDF]

BMC Biotechnol
Abd-Elhalim BT, El-Bana GG, El-Sayed AF, Abdel-Ghani GE.   +3 more
europepmc   +1 more source

The synthesis and investigation of novel 3-benzoylbenzofurans and pyrazole derivatives for anti-HIV activity. [PDF]

RSC Med Chem
Khuzwayo SS, Selepe MA, Meyer D, Gama NH.   +3 more
europepmc   +1 more source

Exercise in 1-aryl-3-CF₃-1<i>H</i>-pyrazoles: regioselective synthesis of 4-/5-iodides and cross-coupling reactions. [PDF]

RSC Adv
Świątek K, Utecht-Jarzyńska G, Jasiński M.   +2 more
europepmc   +1 more source