Results 11 to 20 of about 19,589 (195)

Antiparasitic Behavior of Trifluoromethylated Pyrazole 2-Amino-1,3,4-thiadiazole Hybrids and Their Analogues: Synthesis and Structure-Activity Relationship

Frontiers in Pharmacology, 2020
A series of trifluoromethylated pyrazole thiosemicarbazone, trifluromethylated pyrazole isothiosemicarbazone, and trifluoromethylated pyrazole 2-amino-1,3,4-thiadiazole hybrids were synthesized and evaluated in vitro against the promastigote form of ...
Jeniffer do Nascimento Ascencio Camargo, Karlos Eduardo Pianoski, Mariellen Guilherme dos Santos, Danielle Lazarin-Bidóia, Hélito Volpato, Sidnei Moura, Celso Vataru Nakamura, Fernanda Andreia Rosa   +7 more
doaj   +1 more source

PCW-1001, a Novel Pyrazole Derivative, Exerts Antitumor and Radio-Sensitizing Activities in Breast Cancer

Frontiers in Oncology, 2022
As pyrazole and its derivatives have a wide range of biological activities, including anticancer activity, the design of novel pyrazole derivatives has emerged as an important research field.
Minsung Kang, Navin Pandit, Ah-Young Kim, Suk Joon Cho, Young-Ju Kwon, Young-Ju Kwon, Jiyeon Ahn, Kyu Myung Lee, Sangwook Wu, Jeong Su Oh, Kwan-Young Jung, Kwan-Young Jung, Jae-Sung Kim, Jae-Sung Kim   +13 more
doaj   +1 more source

Recent Applications of the Multicomponent Synthesis for Bioactive Pyrazole Derivatives

Molecules, 2022
Pyrazole and its derivatives are considered a privileged N-heterocycle with immense therapeutic potential. Over the last few decades, the pot, atom, and step economy (PASE) synthesis of pyrazole derivatives by multicomponent reactions (MCRs) has gained ...
Diana Becerra, Rodrigo Abonia, Juan-Carlos Castillo   +2 more
doaj   +1 more source

An efficient metal-free and catalyst-free C–S/C–O bond-formation strategy: synthesis of pyrazole-conjugated thioamides and amides

Beilstein Journal of Organic Chemistry, 2023
An operationally simple and metal-free approach is described for the synthesis of pyrazole-tethered thioamide and amide conjugates. The thioamides were generated by employing a three-component reaction of diverse pyrazole C-3/4/5 carbaldehydes, secondary
Shubham Sharma, Dharmender Singh, Sunit Kumar, Vaishali, Rahul Jamra, Naveen Banyal, Deepika, Chandi C. Malakar, Virender Singh   +8 more
doaj   +1 more source

Current status of pyrazole and its biological activities

Journal of Pharmacy and Bioallied Sciences, 2016
Pyrazole are potent medicinal scaffolds and exhibit a full spectrum of biological activities. This review throws light on the detailed synthetic approaches which have been applied for the synthesis of pyrazole.
Mohd Javed Naim, Ozair Alam, Farah Nawaz, Md. Jahangir Alam, Perwaiz Alam   +4 more
doaj   +1 more source

Crystal structure of 6-amino-4-(3-bromo-4-methoxyphenyl)-3-methyl-2,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile dimethyl sulfoxide monosolvate

Acta Crystallographica Section E: Crystallographic Communications, 2015
In the pyrazole molecule of the title solvate, C15H13BrN4O2·C2H6OS, the dihedral angle between the benzene ring and the mean plane of the dihydropyrano[2,3-c]pyrazole ring system [r.m.s deviation = 0.031 (2) Å] is 86.71 (14)°.
Sammer Yousuf, Huma Bano, Munira Taj Muhammad, Khalid Mohammed Khan   +3 more
doaj   +1 more source

One‐Pot Amidation/C─H Halogenation by an Efficient Electrochemical Cascade

Angewandte Chemie, EarlyView.
A sustainable electrochemical cascade enables the one‐pot synthesis of regioselectively halogenated N‐aryl amides from readily available amines and acyl halides under mild conditions. The method merges amidation and C─H halogenation in a single operational step, delivering broad substrate scope, high selectivity, and scalability, and provides an ...
Sudipta Ponra, Ruzal Sitdikov, Hasil Aman, Alyssio Calis, Gergely Laczkó, Virgile Rouffeteau, Maxime R. Vitale, Imre Pápai, Oscar Verho   +8 more
wiley   +2 more sources

Chiral versus achiral crystal structures of 4-benzyl-1H-pyrazole and its 3,5-diamino derivative

Acta Crystallographica Section E: Crystallographic Communications
The crystal structures of 4-benzyl-1H-pyrazole (C10H10N2, 1) and 3,5-diamino-4-benzyl-1H-pyrazole (C10H12N4, 2) were measured at 150 K. Although its different conformers and atropenantiomers easily interconvert in solution by annular tautomerism and/or ...
Emily R. Hayward, Matthias Zeller, Gellert Mezei   +2 more
doaj   +1 more source

{2,6-Bis[(2,6-diisopropylphosphanyl)oxy]-4-fluorophenyl-κ3P,C1,P′}(1H-pyrazole-κN2)nickel(II) hexafluorophosphate

Acta Crystallographica Section E, 2012
The title compound, [Ni(C18H30FO2P2)(C3H4N2)]PF6, was prepared by halide abstraction with TlPF6 in the presence of CH3CN in CDCl3 from the respective neutral pincer chlorido analogue followed by addition of pyrazole.
Man-Lung Kwan, Sara J. Conry, Charles S. Carfagna, Loren P. Press, Oleg V. Ozerov, Norris W. Hoffman, Richard E. Sykora   +6 more
doaj   +1 more source

Recent Advancement in Drug Design and Discovery of Pyrazole Biomolecules as Cancer and Inflammation Therapeutics

Molecules, 2022
Pyrazole, an important pharmacophore and a privileged scaffold of immense significance, is a five-membered heterocyclic moiety with an extensive therapeutic profile, viz., anti-inflammatory, anti-microbial, anti-anxiety, anticancer, analgesic ...
Md. Jahangir Alam, Ozair Alam, Mohd. Javed Naim, Farah Nawaz, Ajay Manaithiya, Mohd Imran, Hamdy Khamees Thabet, Sultan Alshehri, Mohammed M. Ghoneim, Prawez Alam, Faiyaz Shakeel   +10 more
doaj   +1 more source