Results 71 to 80 of about 19,589 (195)

Current progress in synthetic and medicinal chemistry of pyrazole hybrids as potent anticancer agents with SAR studies

Future Journal of Pharmaceutical Sciences
Background One of the most serious and potentially hazardous diseases that trouble the globe today is cancer. Among various cancer treatment options, chemotherapy is currently one of the most efficient ways to remove cancer.
Bhupender Nehra, Manoj Kumar, Viney Chawla, Pooja A. Chawla   +3 more
doaj   +1 more source

3-Acetyl-5-phenyl-1-p-tolyl-1H-pyrazole-4-carbonitrile

Acta Crystallographica Section E, 2012
In the title pyrazole derivative, C19H15N3O, the central pyrazole ring makes dihedral angles of 42.71 (9) and 61.34 (9)°, respectively, with the phenyl and p-tolyl rings.
Hatem A. Abdel-Aziz, Hazem A. Ghabbour, Suchada Chantrapromma, Hoong-Kun Fun   +3 more
doaj   +1 more source

Susceptibility of Phthorimaea absoluta (Meyrick) (Lepidoptera: Gelechiidae) to novel and established insecticides in Brazil: resistance survey, baseline, and implications for management

Pest Management Science, EarlyView.
Baseline susceptibility of Phthorimaea absoluta to novel insecticides isocycloseram and tolfenpyrad was established in Brazil. Diagnostic doses were proposed for early resistance detection. Early tolfenpyrad tolerance and abamectin‐driven cross‐tolerance to isocycloseram via oxidases highlight cross‐resistance risks, emphasizing the need for routine ...
Vitor Quintela, Teófilo P Langa, José VCR Dantas, Marcos de Oliveira, Herbert AA Siqueira   +4 more
wiley   +1 more source

The continuing significance of chiral agrochemicals

Pest Management Science, Volume 81, Issue 4, Page 1697-1716, April 2025.
In the time frame 2018–2023, around 43% of the 35 chiral agrochemicals introduced to the market (herbicides, fungicides, insecticides, acaricides, and nematicides) contain one or more stereogenic centers in the molecule, and almost 69% of them have been marketed as racemic mixtures of enantiomers or stereoisomers.
Peter Jeschke
wiley   +1 more source

Tris(3,5-dimethyl-1H-pyrazole-κN2)(pyridine-2,6-dicarboxylato-κ3O2,N,O6)cobalt(II) monohydrate

Acta Crystallographica Section E, 2009
The reaction of Co(NO3)2·3H2O with pyridine-2,6-dicarboxylic acid and 3,5-dimethyl-1H-pyrazole in a 1:1:3 molar ratio affords the title complex, [Co(C7H3NO4)(C5H8N2)3]·H2O.
Kun-Hua Lin, Zhe-Yin Yu, Yan-Hua Zhong, Min Shao   +3 more
doaj   +1 more source

Rhenium(Iv) Complexes with Pyrazole and Substituted-pyrazoles

, 1989
Department of Chemistry,Jadavpur University. Calcutta-700 082 Manuscript received 10 February 1988, revised 26 September 1988, accepted 14 December 1988 IN this paper we report rhenium(Iv) complexes of the type Re2 O2 Cl4,L4, where L=pyrazole (Pz), 3-methylpyrazole (MePz), 3,5-dimethylpyrazole (DmPz), 3,4,5-trimethylpyrazole (TmPz) and 1,3,4,5 ...
SHYMAL ROY CHOWDHURY, MAHENDRA KUMAR SIPANI, BIMANESH SUR   +2 more
openaire   +1 more source

Diamine Grafting of Pyrazole‐Based MOF‐303 for Diluted‐Source CO2 Capture

Small, EarlyView.
Vapor‐phase diffusion of ethylenediamine (EDA) into the pyrazole‐based MOF‐303 framework enables efficient amine grafting via pyrazole deprotonation and ion‐pair–stabilized hydrogen bonding with the pore walls. Spectroscopic analyses elucidate the interaction, while breakthrough experiments confirm the material's performance and cyclability.
Giuseppe Mastronardi, Jacopo Perego, Charl Xavier Bezuidenhout, Wim Temmerman, Veronique Van Speybroeck, Valentina Crocellà, Silvia Bracco, Nello Li Pira, Angiolina Comotti, Silvia Bordiga   +9 more
wiley   +1 more source

Advances in the Different Synthetic Routes of Fluorinated Hydrazines

The Chemical Record, EarlyView.
This review highlights the various routes to the preparation of fluorinated hydrazines, thereby promoting the exploration of innovative methods for the synthesis of new N‐fluorinated hydrazines. Their synthesis mainly involves synthetic routes such as organometallic, organocatalytic, and photocatalytic.
Dimitra Kyrko, Benoît Crousse
wiley   +1 more source

Folding, misfolding, and regulation of intracellular traffic of G protein‐coupled receptors involved in the hypothalamic–pituitary–gonadal axis

Andrology, EarlyView.
Abstract Background G protein‐coupled receptors are a large and functionally diverse family of membrane receptors involved in a number of biological processes. Like other proteins, G protein‐coupled receptors need to be properly folded in order to traffic to the plasma membrane and interact with agonist.
Alfredo Ulloa‐Aguirre, Ross C. Anderson, Teresa Zariñán, Rubén Gutiérrez‐Sagal, Eduardo Jardón‐Valadez, Claire L. Newton   +5 more
wiley   +1 more source

Covalent drug discovery: Progress against key targets, emerging strategies and lessons learnt

British Journal of Pharmacology, EarlyView.
Abstract Covalent drug discovery is currently experiencing a boom in industrial and academic interest. To date, at least 75 covalent drugs have received regulatory approval, targeting both traditional target classes and more challenging proteins for which other approaches failed. In many cases, unique aspects of covalent targeting are essential for the
Charles P. Brown, Alan Armstrong, David J. Mann   +2 more
wiley   +1 more source