Results 71 to 80 of about 64,409 (320)

KCa3.1 inhibition switches the phenotype of glioma-infiltrating microglia/macrophages [PDF]

, 2016
Among the strategies adopted by glioma to successfully invade the brain parenchyma is turning the infiltrating microglia/macrophages (M/MΦ) into allies, by shifting them toward an anti-inflammatory, pro-tumor phenotype.
Catalano, M, D'Alessandro, G, Di Angelantonio, S, Esposito, V, Esposito, V, Golia, MT, Grimaldi, A, Grössinger, EM, Limatola, C, Ragozzino, D, Santoro, A, Wulff, H   +11 more
core   +2 more sources

Solvent‐Free Mechanocatalytic Reduction of Nitro Compounds with Hydrogen Gas and its Application in the Synthesis of Drugs and their Intermediates

Advanced Synthesis &Catalysis, EarlyView.
A solvent‐free mechanochemical reduction of nitro compounds using hydrogen gas is presented. In addition to enabling the synthesis of a variety of functionalized aniline derivatives, the method has been scaled up to gram quantities, evaluated for trace metal impurities, and applied to the synthesis of pharmaceutical compounds and their precursors.
Samarth Bhatnagar, Michael Felderhoff, Jan‐Hendrik Schöbel   +2 more
wiley   +1 more source

Two tautomers in the same crystal: 3-(4-fluorophenyl)-1H-pyrazole and 5-(4-fluorophenyl)-1H-pyrazole

Acta Crystallographica Section E, 2014
The title co-crystal, 3-(4-fluorophenyl)-1H-pyrazole–5-(4-fluorophenyl)-1H-pyrazole (1/1), C9H7FN2, crystallizes with four independent molecules (A, B, C and D) in the asymmetric unit exhibiting two tautomeric forms (A and D; B and C) due to N—H proton ...
Thammarse S. Yamuna, Manpreet Kaur, Jerry P. Jasinski, Brian J. Anderson, H. S. Yathirajan   +4 more
doaj   +1 more source

Metal‐Ligand Complexes as Multifunctional Platforms for Photo‐Activated Cancer Therapy

Advanced Science, EarlyView.
Metal‐ligand complexes serve as multifunctional platforms for photo‐activated cancer therapy, facilitating photothermal and photodynamic effects through light absorption and reactive oxygen species generation. This review categorizes these complexes by ligand and metal types, examines their roles in combined therapeutic approaches, and explores ...
Jeonga Kim, Saehan Choi, Yoonsung Nam
wiley   +1 more source

Generalizing Vinyl Halide Cross‐Coupling Reactions with Photoredox and Photoredox/Nickel Dual Catalysis

Angewandte Chemie, EarlyView.
A general strategy has been developed for predictable and robust vinyl halide cross‐coupling reactions. This approach demonstrates broad applicability across seven distinct bond‐forming transformations, featuring wide electrophile and nucleophile scope, high tolerance for functional groups, and suitability for late‐stage functionalization of complex ...
Kousik Das, Nayan Saha, Zhuofan Li, Indrajit Ghosh, Burkhard König   +4 more
wiley   +2 more sources

New Hybrid Pyrazole and Imidazopyrazole Antinflammatory Agents Able to Reduce ROS Production in Different Biological Targets

Molecules, 2020
Several anti-inflammatory agents based on pyrazole and imidazopyrazole scaffolds and a large library of substituted catechol PDE4D inhibitors were reported by us in the recent past.
Chiara Brullo, Matteo Massa, Federica Rapetti, Silvana Alfei, Maria B. Bertolotto, Fabrizio Montecucco, Maria Grazia Signorello, Olga Bruno   +7 more
doaj   +1 more source

From Bench to Bedside: Emerging Paradigms in CAR‐T Cell Therapy for Solid Malignancies

Advanced Science, EarlyView.
This review discusses emerging paradigms in CAR‐T cell therapy for solid tumors, emphasizing strategies to overcome therapeutic barriers through synthetic biology, immune engineering, and combinatorial approaches. It highlights advancements in logic gating, modulation of the immune microenvironment, and innovative cell designs, providing valuable ...
Yang Chen, Ran Ren, Lirong Yan, Yu Zhou, Ruokai Sun, Huicong Song, Hongfei Yan, Yongsheng Li   +7 more
wiley   +1 more source

Efficient Regioselective Iodination of Pyrazole Derivatives Mediated by Cadmium(II) Acetate

ChemistryOpen
The present study focuses on the iodination of pyrazoles mediated by cadmium (II) acetate. The objects of research were compounds with pyrazole rings substituted by N‐propargyl, C, N‐alkyl groups.
Dr. Nina G. Hobosyan, Dr. Kristine V. Balyan, Lusine A. Movsisyan, Dr. Varduhi S. Hovsepyan, Armen G. Ayvazyan, Dr. Henrik A. Panosyan, Prof. Dr. Hovhannes S. Attaryan, Dr. Hmayak B. Sargsyan, Haykanush R. Pogosyan   +8 more
doaj   +1 more source

Assessing biogeochemical effects and best management practice for a wheat–maize cropping system using the DNDC model [PDF]

, 2014
Contemporary agriculture is shifting from a single-goal to a multi-goal strategy, which in turn requires choosing best management practice (BMP) based on an assessment of the biogeochemical effects of management alternatives.
Cui, Feng, Deng, Jia, Liu, Chunyan, Wang, K., Zheng, Xunhua, Zhou, Zaixing   +5 more
core   +2 more sources

Comprehensive Genetic Map of Muscle Lipidome Reveals Novel Insights Into Flavor Variation in Ruminant Meat

Advanced Science, EarlyView.
Ruminant meat is widely appreciated for its distinctive flavor. Lipids play a central role in influencing meat flavor, yet their genetic and biochemical basis remains largely unexplored. Here, a comprehensive lipid genetic map of sheep muscle is constructed and 20 candidate genes potentially modulating lipid levels are identified to provide a roadmap ...
Xueying Zhang, Yuanyuan Kong, Jialei Chen, Ran Li, Zhongyu Wang, Yali Song, Tianshu Dai, Yuxin Fu, Beixiang Jiang, Jize Zeng, Shengwei Pei, Yangkai Liu, Qianjie Feng, Weiwei Fu, Zehu Yuan, Joram Mwashigadi Mwacharo, Fadi Li, Xiangpeng Yue   +17 more
wiley   +1 more source