Multicomponent syntheses of pyrazoles via (3 + 2)-cyclocondensation and (3 + 2)-cycloaddition key steps [PDF]
Beilstein Journal of Organic ChemistryPyrazoles are rarely found in nature but are traditionally used in the agrochemical and pharmaceutical industries, while other areas of use are also actively developing. However, they have also found numerous other applications.
Ignaz Betcke +3 more
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Synthesis of 4-functionalized pyrazoles via oxidative thio- or selenocyanation mediated by PhICl2 and NH4SCN/KSeCN [PDF]
Beilstein Journal of Organic ChemistryA series of 4-thio/seleno-cyanated pyrazoles was conveniently synthesized from 4-unsubstituted pyrazoles using NH4SCN/KSeCN as thio/selenocyanogen sources and PhICl2 as the hypervalent iodine oxidant.
Jialiang Wu +6 more
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Pyrazoles as potential anti-angiogenesis agents: a contemporary overview
Frontiers in Chemistry, 2014 Angiogenesis is a mulit-step process by which new blood vessels are formed from preexisting vasculature. It is a key rate limiting factor in tumor growth since new blood vessels are necessary to increase tumor size. In this context it has been shown that
Konstantinos M Kasiotis +1 more
exaly +3 more sources
Temperature-Controlled Divergent Synthesis of Pyrazoles and 1-Tosyl-1H-pyrazoles under Transition-Metal-Catalyst- and Oxidant-Free Conditions [PDF]
MoleculesHerein, a general and practical temperature-controlled approach for the divergent synthesis of pyrazoles and 1-tosyl-1H-pyrazoles via electrophilic cyclization in the absence of transition-metal catalysts and oxidants was developed.
Kai Wang +3 more
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Regio- and Stereoselective Switchable Synthesis of (E)- and (Z)-N-Carbonylvinylated Pyrazoles
Molecules, 2023 Regio- and stereoselective switchable synthesis of (E)- and (Z)-N-carbonylvinylated pyrazoles is first developed by using the Michael addition reaction of pyrazoles and conjugated carbonyl alkynes.
Xue Zhang +3 more
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Substituted Pyrazoles and Their Heteroannulated Analogs—Recent Syntheses and Biological Activities
Molecules, 2021 Pyrazoles are considered privileged scaffolds in medicinal chemistry. Previous reviews have discussed the importance of pyrazoles and their biological activities; however, few have dealt with the chemistry and the biology of heteroannulated derivatives ...
Mohamed Ramadan +4 more
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Study of thermodynamic properties of substitutional mixture of Co(II)- and Fe(II)-based octacyanoniobates [PDF]
Phys. Rev. B 104 (2021) 214428, 2021 A comprehensive study of thermodynamic properties of three samples of bimetallic molecular magnets [Co$^{\mathrm{II}}$(pyrazole)$_{4}$]$_{2x}$[Fe$^{\mathrm{II}}$(pyrazole)$_{4}$]$_{2(1-x)}$[Nb$^{\mathrm{IV}}$(CN)$_{8}$]$\cdot$4H$_{2}$O with $x$=0 (Co$_{2}$Nb), 0.5 (CoFeNb), and 1 (Fe$_{2}$Nb) is reported.
arxiv +1 more source
Acid Catalyzed N-Alkylation of Pyrazoles with Trichloroacetimidates
Organics, 2022 N-Alkyl pyrazoles are important heterocycles in organic and medicinal chemistry, demonstrating a wide range of biological activity. A new method for the N-alkylation of pyrazoles has been developed using trichloroacetimidate electrophiles and a Brønsted ...
Rowan I. L. Meador +2 more
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Natural and Biomimetic Antitumor Pyrazoles, A Perspective
Molecules, 2020 The present review presents an overview of antitumor pyrazoles of natural or bioinspired origins. Pyrazole compounds are relatively rare in nature, the first ones having been reported in 1966 and being essentially used as somniferous drugs.
Nádia E. Santos +3 more
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Molbank, 2022 Pyrazoles have potential applications in the agrochemical and medicinal chemistry industries as pesticides, anti-inflammatory medications, and antitumor drugs. Fluorinated fused-ring pyrazoles may also possess medicinally useful properties.
Linh Lam, Sang H. Park, Joseph Sloop
doaj +1 more source