Results 1 to 10 of about 40,394 (295)
Multicomponent syntheses of pyrazoles via (3 + 2)-cyclocondensation and (3 + 2)-cycloaddition key steps [PDF]
Beilstein Journal of Organic ChemistryPyrazoles are rarely found in nature but are traditionally used in the agrochemical and pharmaceutical industries, while other areas of use are also actively developing. However, they have also found numerous other applications.
Ignaz Betcke +3 more
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Regio- and Stereoselective Switchable Synthesis of (E)- and (Z)-N-Carbonylvinylated Pyrazoles
Molecules, 2023 Regio- and stereoselective switchable synthesis of (E)- and (Z)-N-carbonylvinylated pyrazoles is first developed by using the Michael addition reaction of pyrazoles and conjugated carbonyl alkynes.
Xue Zhang +3 more
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Substituted Pyrazoles and Their Heteroannulated Analogs—Recent Syntheses and Biological Activities
Molecules, 2021 Pyrazoles are considered privileged scaffolds in medicinal chemistry. Previous reviews have discussed the importance of pyrazoles and their biological activities; however, few have dealt with the chemistry and the biology of heteroannulated derivatives ...
Mohamed Ramadan +4 more
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Acid Catalyzed N-Alkylation of Pyrazoles with Trichloroacetimidates
Organics, 2022 N-Alkyl pyrazoles are important heterocycles in organic and medicinal chemistry, demonstrating a wide range of biological activity. A new method for the N-alkylation of pyrazoles has been developed using trichloroacetimidate electrophiles and a Brønsted ...
Rowan I. L. Meador +2 more
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Natural and Biomimetic Antitumor Pyrazoles, A Perspective
Molecules, 2020 The present review presents an overview of antitumor pyrazoles of natural or bioinspired origins. Pyrazole compounds are relatively rare in nature, the first ones having been reported in 1966 and being essentially used as somniferous drugs.
Nádia E. Santos +3 more
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SUBSTITUTED 4-NITROSOPYRAZOLES IN THE DIELS-ALDER REACTION
Siberian Journal of Life Sciences and Agriculture, 2021 Background. 4-Nitrosopyrazoles have become widespread in the pharmaceutical industry and in chemistry due to their high reactivity and biological activity. However, the interaction of 3,5-substituted 4-nitroso-1H-pyrazoles with diene hydrocarbons has not
Darya S. Volkova +4 more
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Molbank, 2022 Pyrazoles have potential applications in the agrochemical and medicinal chemistry industries as pesticides, anti-inflammatory medications, and antitumor drugs. Fluorinated fused-ring pyrazoles may also possess medicinally useful properties.
Linh Lam, Sang H. Park, Joseph Sloop
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Carbamidine-substituted Pyrazoles [PDF]
Nature, 1951 THE ease with which 1-substituted pyrazoles may be converted into the free imino compounds varies with the nature of the 1-substituent and the reacting substance. Thus, 1,3,5-trimethyl pyrazole may be nitrated1 and 1-phenyl pyrazole reduced to the pyrazoline2 without loss of the N-methyl or N-phenyl groups respectively.
F L, SCOTT, C M B, MURPHY, J, REILLY
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Nickel-Catalyzed, One-Pot Synthesis of Pyrazoles
Chemistry Proceedings, 2022 Recently, multi-component, one-pot reactions have been shown to be efficient and environmentally friendly methods compared to traditional, linear-step syntheses.
Nassima Medjahed +4 more
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Preparation of novel acyl pyrazoles and triazoles by means of oxidative functionalization reactions
Heterocyclic Communications, 2023 Novel acyl pyrazoles and acyl triazoles have been prepared by means of the oxidative amidation of aldehydes in the presence of the requisite azole. Yields range from modest to good in both cases, and some limitations of the substrate scope have been ...
Wadey Geoffrey P. +3 more
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