Results 1 to 10 of about 38,433 (148)

Facile synthesis of isoxazoles and pyrazoles from ß-diketohydrazones [PDF]

, 2009
Indexación: ScieloNew 3,5-dimethyl-4-[(E)-4-(R1-phenyl)diazenyl]isoxazoles and 3,5-dimethyl-1-(R2-phenyl)-4-[(E)-(R1-phenyl)diazenyl]-1H-pyrazoles may be obtained by reaction of 3-[2-(R1-phenyl)hydrazono)]pentane-2,4-dione with H2NOH-HCl and R2-4-C6H4 ...
Bustos, Carlos, Cárcamo, Juan-Guillermo, Ríos, Marcela, Schott, Eduardo, Sánchez, Christian   +4 more
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The structure of the agrochemical fungicidal 4-Chloro-3-(3,5-dichloropheny)-1H-pyrazole, RPA 406194 and related compounds [PDF]

, 2003
The difficulties to obtain convenient monocrystals of the important fungicide RPA 406194 have been overcome by a combination of solid state 13C NMR, X-ray powder diffraction and molecular modeling.
Abboud, Aguilar-Parrilla, Bennema, Berkovitch-Yellin, Burton, Cativiela, Cativiela, Claramunt, Dunitz, Elguero, Elguero, Eliel, Foces-Foces, Grimbergen, Harris, Hartman, Hartman, Hartman, Hartman, Jean Paul Canselier, Jean-Pierre Vors, José Elguero, Lin, Lin, Lommerse, López, Marı́a Luisa Jimeno, Minkin, Nadine Gabas, Nadine Jagerovic, Olivieri, Stothers, Vincent Gerbaud, Weissbuch, Winn, Winn   +35 more
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Combined experimental and computational investigations of rhodium-catalysed C-H functionalisation of pyrazoles with alkenes [PDF]

, 2014
Detailed experimental and computational studies have been carried out on the oxidative coupling of the alkenes C(2)H(3)Y (Y=CO(2)Me (a), Ph (b), C(O)Me (c)) with 3-aryl-5-R-pyrazoles (R=Me (1 a), Ph (1 b), CF(3) (1 c)) using a [Rh(MeCN)(3)Cp*][PF(6)](2 ...
Algarra, Andrés G., Davies, David L., Khamker, Qudsia, Macgregor, Stuart A., McMullin, Claire L., Singh, Kuldip, Villa-Marcos, Barbara   +6 more
core   +1 more source

Revisiting the structure and chemistry of 3(5)-Substituted Pyrazoles [PDF]

, 2019
Pyrazoles are known as versatile scaffolds in organic synthesis and medicinal chemistry, often used as starting materials for the preparation of more complex heterocyclic systems with relevance in the pharmaceutical field.
Alam, Alina Secrieru, Alkorta, Andes, Anwar, Behr, Brown, Castillo, Catalan, Chauhan, Clark, Elguero, Elnagdi, Favre, Fichez, Hall, Horta, Katritzky, Katritzky, Kost, Kumar, Larina, Maria Lurdes Santos Cristiano, Mert, Minkin, Minkin, Mohamed, Nagy, Nimbalkar, Paul Michael O’Neill, Schofield, Simons, Szajda, Taylor, Zerbi   +34 more
core   +2 more sources

Sydnone Cycloaddition Route to Pyrazole-Based Analogs of Combretastatin A4. [PDF]

, 2016
The combretastatins are an important class of tubulin-binding agents. Of this family, a number of compounds are potent tumor Vascular Disrupting Agents (VDAs) and have shown promise in the clinic for cancer therapy.
Brown, A.W., Fisher, M., Harrity, J.P., Kanthou, C., Tozer, G.M.   +4 more
core   +2 more sources

Discovery of new mutually orthogonal bioorthogonal cycloaddition pairs through computational screening. [PDF]

, 2015
Density functional theory (DFT) calculations and experiments in tandem led to discoveries of new reactivities and selectivities involving bioorthogonal sydnone cycloadditions.
Houk, KN, Liang, Yong, Murphy, Jennifer M, Narayanam, Maruthi Kumar   +3 more
core   +1 more source

Synthesis, biological evaluation and SAR study of novel pyrazole analogues as inhibitors of Mycobacterium tuberculosis [PDF]

, 2008
As a continuation of our previous work that turned toward the identification of antimycobacterial compounds with innovative structures, two series of pyrazole derivatives were synthesized by parallel solution-phase synthesis and were assayed as ...
Ahmad, Alessandro De Logu, Beatrice Bechi, Bieringer, Brooks, Burman, Daniele Castagnolo, De Logu, Espinal, Fabrizio Manetti, Frieden, Holzer, Holzer, Janin, Jensen, Kutterer, Lorenza Chisu, Manetti, Manetti, Marco Radi, Matteo Magnani, Maurizio Botta, O’Brien, Rita Meleddu, Sibilla Supino, Smellie, Smellie, Smellie   +27 more
core   +1 more source

Symmetric 3,5-Pyrazole and Isoxazole Heterocycles Comprising a Bent Core Unit: Synthesis and Mesomorphic Characterisation [PDF]

, 2015
The synthesis and characterisation of some new liquid crystalline (LC) heteroaromatic compounds containing the five-membered pyrazole/isoxazole rings is reported. Some of the compounds exhibited enantiotropic LC properties.
Hariprasad, S., Srinivasa, H.T.
core   +1 more source

Synthesis, biological evaluation, and SAR study of novel pyrazole analogues as inhibitors of Mycobacterium tuberculosis: Part 2. Synthesis of rigid pyrazolones [PDF]

, 2009
Two series of novel rigid pyrazolone derivatives were synthesized and evaluated as inhibitors of Mycobacterium tuberculosis (MTB), the causative agent of tuberculosis. Two of these compounds showed a high activity against MTB (MIC = 4 μg/mL).
Alessandro De Logu, Beatrice Bechi, Biava, Biava, Biava, Brock, Castagnolo, Daniele Castagnolo, De Logu, Deidda, Fabrizio Manetti, Gutierrez-Lugo, Holzer, Janin, Mafalda Pagano, Manetti, Manuela Saddi, Marco Radi, Maurizio Botta, Rita Meleddu   +19 more
core   +1 more source

1,3-Dipolar cycloadditions of 2-thio-3-chloroacrylamides with diazoalkanes [PDF]

, 2010
2-Thio-3-chloroacrylamides undergo 1,3-dipolar cycloadditions with diazoalkanes leading to a series of novel pyrazolines and pyrazoles. The mechanistic and synthetic features of the cycloadditions to the 2-thio-3-chloroacrylamides at both the sulfide and
Kissane, Marie, Lawrence, Simon E., Maguire, Anita R.   +2 more
core   +1 more source