Results 31 to 40 of about 13,389 (142)

Nanozymes for Energy and Environmental Sustainability

Advanced Science, EarlyView.
At present, the widely used nanozymes are oxidoreductase and hydrolase, which have proved to have great application prospects in energy and environment. ABSTRACT Nanozymes have shown remarkable promise in addressing pressing challenges in energy and environmental sustainability.
Xiaoqi Li, Jinxing Chen, Shaojun Dong
wiley   +1 more source

Development and Structural Characterization of UTE‐156, a Covalent Inhibitor of the VCP/p97 AAA+ ATPase

Advanced Science, EarlyView.
The AAA+ ATPase Valosin‐containing protein (VCP/p97) regulates protein homeostasis by unfolding ubiquitinated substrates. Here, we describe UTE‐156, a novel irreversible covalent inhibitor that modifies Cys522 in the D2 ATPase motor domain. Although its pharmacochemical limitations preclude immediate therapeutic use, UTE‐156 serves as a valuable ...
Daniela Tamayo‐Jaramillo, Subramanya Hegde, Xuan Jia, Kimberly Coffman, Hariprasad Vankayalapati, David Bearss, Kevin B. Jones, Alex W. Stark, Peter S. Shen   +8 more
wiley   +1 more source

Synthesis of 2H-furo[2,3-c]pyrazole ring systems through silver(I) ion-mediated ring-closure reaction

Beilstein Journal of Organic Chemistry, 2019
Fused pyrazole ring systems are common structural motifs of numerous pharmaceutically important compounds. Nevertheless, access to derivatives of the aromatic 2H-furo[2,3-c]pyrazole ring system is still quite limited, and their chemistry and functional ...
Vaida Milišiūnaitė, Rūta Paulavičiūtė, Eglė Arbačiauskienė, Vytas Martynaitis, Wolfgang Holzer, Algirdas Šačkus   +5 more
doaj   +1 more source

Revisiting the Chemistry of Vinylpyrazoles: Properties, Synthesis, and Reactivity

Molecules, 2022
Vinylpyrazoles, also known as pyrazolyl olefins, are interesting motifs in organic chemistry but have been overlooked. This review describes the properties and synthetic routes of vinylpyrazoles and highlights their versatility as building blocks for the
Vera L. M. Silva, Artur M. S. Silva
doaj   +1 more source

Shedding Light on Synthetic Autocatalysis: From Conventional Closed‐Shell Chemistries to Overlooked Open‐Shell Occurrences

Chemistry – A European Journal, EarlyView.
Why add another catalyst when the product itself holds the power to catalyze its own formation? Autocatalysis in synthetic chemistry enhances reaction efficiency and uncovers novel catalytic behavior across both closed‐shell and open‐shell systems, expanding reactivity and enabling innovative design strategies.
Jaspreet Kaur, Joshua P. Barham
wiley   +1 more source

Temperature-Controlled Divergent Synthesis of Pyrazoles and 1-Tosyl-1H-pyrazoles under Transition-Metal-Catalyst- and Oxidant-Free Conditions

Molecules
Herein, a general and practical temperature-controlled approach for the divergent synthesis of pyrazoles and 1-tosyl-1H-pyrazoles via electrophilic cyclization in the absence of transition-metal catalysts and oxidants was developed.
Kai Wang, Wenjing Xu, Chengcai Xia, Xianting Cao   +3 more
doaj   +1 more source

An Approach to 1,1-Disubstituted Pyrazolylcyclopropane Building Blocks

SynOpen, 2017
An approach to isomeric 1,1-disubstituted pyrazolylcyclopropanes that relies on lithium diisopropylamide (LDA) mediated bis-alkylation­ of the corresponding pyrazolylacetonitriles is developed.
Pavel S. Nosik, Oleksiy S. Artamonov, Sergey V. Ryabukhin, Oleksandr O. Grygorenko   +3 more
doaj   +1 more source

Porphyrin‐Geländer–Helical Conjugated Banister Type Porphyrin Dyads

Chemistry – A European Journal, EarlyView.
Porphyrin arrays go chiral–A porphyrin Geländer macrocycle represents the intriguing prototype architecture of helically chiral butadiyne‐linked porphyrin arrays. This study combines synthetic, spectroscopic, and computational methods to shed light on its structure, chiroptical properties, and tunability, highlighting its promise for advancing ...
Joël F. Keller, Adriano D'Addio, Marcel Mayor   +2 more
wiley   +1 more source

The pyrazolo[4,3-c]pyrazole core as a novel and versatile scaffold for developing dual DYRK1A-CLK1 inhibitors targeting key processes of Alzheimer's disease pathology

European Journal of Medicinal Chemistry Reports
In the current study, we designed, synthesized, and characterized a series of substituted pyrazolo[4,3-c]pyrazoles. These novel compounds were evaluated in vitro for their inhibitory activity over a panel of protein kinases to determine their potential ...
Vaia-Argyro Bakalakou, Barbara Mavroidi, Amalia D. Kalampaliki, Béatrice Josselin, Stéphane Bach, Alexios-Leandros Skaltsounis, Panagiotis Marakos, Nicole Pouli, Maria Pelecanou, Vassilios Myrianthopoulos, Sandrine Ruchaud, Ioannis K. Kostakis   +11 more
doaj   +1 more source

An Example of Polynomial Expansion: The Reaction of 3(5)-Methyl-1H-Pyrazole with Chloroform and Characterization of the Four Isomers

Molecules, 2019
The reaction in phase-transfer catalyzed conditions of 3(5)-methyl-1H-pyrazole with chloroform affords four isomers 333, 335, 355 and 555 in proportions corresponding to the polynomial expansion (a + b)3, with a = 0.6 and b = 0.4, a and b being 3-methyl ...
Vera L. M. Silva, Artur M. S. Silva, Rosa M. Claramunt, Dionisia Sanz, Lourdes Infantes, Ángela Martínez-López, Felipe Reviriego, Ibon Alkorta, José Elguero   +8 more
doaj   +1 more source