Results 41 to 50 of about 38,574 (278)
Advanced Synthesis &Catalysis, EarlyView.A solvent‐free mechanochemical reduction of nitro compounds using hydrogen gas is presented. In addition to enabling the synthesis of a variety of functionalized aniline derivatives, the method has been scaled up to gram quantities, evaluated for trace metal impurities, and applied to the synthesis of pharmaceutical compounds and their precursors.
Samarth Bhatnagar +2 more
wiley +1 more source
Photoredox‐Catalyzed Synthesis of a Novel Class of Fluoroalkyl Pyrazolones
Advanced Synthesis &Catalysis, EarlyView.A photoredox strategy enables regioselective synthesis of fluoroalkyl 2‐pyrazolin‐5‐ones via radical addition and cyclization. This mild, metal‐free method shows a broad substrate scope, operates in batch and flow systems, and offers a sustainable approach to fluorinated heterocycles with potential applications in medicinal chemistry.
Emanuele F. Pissinati +3 more
wiley +1 more source
Metal‐Ligand Complexes as Multifunctional Platforms for Photo‐Activated Cancer Therapy
Advanced Science, EarlyView.Metal‐ligand complexes serve as multifunctional platforms for photo‐activated cancer therapy, facilitating photothermal and photodynamic effects through light absorption and reactive oxygen species generation. This review categorizes these complexes by ligand and metal types, examines their roles in combined therapeutic approaches, and explores ...
Jeonga Kim, Saehan Choi, Yoonsung Nam
wiley +1 more source
A copper-benzotriazole based coordination polymer catalyzes the efficient one-pot synthesis of (N'-substituted)-hydrazo-4-aryl-1,4-dihydropyridines from azines [PDF]
, 2017 A series of new (N’-substituted)-hydrazo-4-aryl-1,4 dihydropyridines were successfully synthesized via a facile one pot catalytic pathway utilizing azines and propiolate esters as starting materials and 1D Cu benzotriazoles based coordination polymer as ...
Batten +39 more
core +1 more source
From Bench to Bedside: Emerging Paradigms in CAR‐T Cell Therapy for Solid Malignancies
Advanced Science, EarlyView.This review discusses emerging paradigms in CAR‐T cell therapy for solid tumors, emphasizing strategies to overcome therapeutic barriers through synthetic biology, immune engineering, and combinatorial approaches. It highlights advancements in logic gating, modulation of the immune microenvironment, and innovative cell designs, providing valuable ...
Yang Chen +7 more
wiley +1 more source
Impact of Glycoclustering on Stiffening of MUC5AC Peptides Revealed by High‐Efficiency Synthesis
Angewandte Chemie, EarlyView.Peptides featuring a previously unattained degree of glycoclustering were obtained by fully automated solid‐phase synthesis in 1,3‐dioxolane/Tween‐20 and diselenide–selenoester ligation. Circular Dichroism (CD) and Pulsed Electron‐Electron Double Resonance (PELDOR) measurements of densely GalNAcylated MUC5AC multi‐tandem repeat peptides provided ...
Arseniy Galashov +9 more
wiley +2 more sources
Synthetic chemistry and biological activity of pentafluorosulphanyl (SF5) organic molecules [PDF]
, 2012 Acknowledgements We thank the European Commission for financial support (Industry Academia Partnerships and Pathways project “PET BRAIN”, Contract No 251482). S.A.
Altomonte, Stefano, Zanda, Matteo
core +1 more source
Advanced Science, EarlyView.Ruminant meat is widely appreciated for its distinctive flavor. Lipids play a central role in influencing meat flavor, yet their genetic and biochemical basis remains largely unexplored. Here, a comprehensive lipid genetic map of sheep muscle is constructed and 20 candidate genes potentially modulating lipid levels are identified to provide a roadmap ...
Xueying Zhang +17 more
wiley +1 more source
Angewandte Chemie, EarlyView.A general strategy has been developed for predictable and robust vinyl halide cross‐coupling reactions. This approach demonstrates broad applicability across seven distinct bond‐forming transformations, featuring wide electrophile and nucleophile scope, high tolerance for functional groups, and suitability for late‐stage functionalization of complex ...
Kousik Das +4 more
wiley +2 more sources
Ultrasonicated synthesis of 1-(2-hydroxyaryl)-3-(pyrrolidin-1-yl)-prop-2-en-1-ones and their antimicrobial screening [PDF]
, 2009 : A facile synthesis of title compounds has been carried out under ultrasound irradiation. The main advantages of the present procedure are shorter reaction time and higher yield.
Bhausaheb Karale +3 more
core +1 more source