Results 41 to 50 of about 27,892 (233)

KEAP1‐NRF2 protein–protein interaction inhibitors: Design, pharmacological properties and therapeutic potential

Medicinal Research Reviews, Volume 43, Issue 1, Page 237-287, January 2023., 2023
Abstract The transcription factor nuclear factor erythroid 2‐related factor 2 (NRF2) is considered the master regulator of the phase II antioxidant response. It controls a plethora of cytoprotective genes related to oxidative stress, inflammation, and protein homeostasis, among other processes.
Enrique Crisman, Pablo Duarte, Esteban Dauden, Antonio Cuadrado, María Isabel Rodríguez‐Franco, Manuela G. López, Rafael León   +6 more
wiley   +1 more source

4-(1H-Pyrazol-1-yl) Benzenesulfonamide Derivatives: Identifying New Active Antileishmanial Structures for Use against a Neglected Disease

Molecules, 2012
Leishmaniasis is a neglected disease responsible for about 56,000 deaths every year. Despite its importance, there are no effective, safe and proper treatments for leishmaniasis due to strain resistance and/or drug side-effects.
Leonor L. Leon, Veronica F. Amaral, Marilene M. Canto-Cavalheiro, Carlos R. Rodrigues, Júlio C. Borges, Alessandra M. T. Souza, Cesar D. Oliveira, Helena C. Castro, Marie-Luce F. Lira, Tathiane A. Proux, Karen S. Charret, Alice M. R. Bernardino, Roberta K. F. Marra   +12 more
doaj   +1 more source

Advancements in Understanding the Physicochemical Properties of Reticular Materials: An In Situ and Operando Spectroscopic Perspective

Advanced Materials, EarlyView.
This review explores how in situ and operando spectroscopic techniques reveal the real‐time behavior of reticular materials, including MOFs and COFs. These methods track material formation and functionalization, structural changes, defect formation, dynamic responses to external triggers, and catalytic processes.
Bettina Baumgartner, Anna Wach, Xinwei Ye, Evelyn Ploetz, Bert M. Weckhuysen   +4 more
wiley   +1 more source

Design, characterization and quantum chemical computations of a novel series of pyrazoles derivatives with potential anti-proinflammatory response

Arabian Journal of Chemistry, 2020
The synthesis and characterization of the full family of 11 pyrazoles were performed by means of UV–Vis, FTIR, 1H NMR, 13C NMR, two-dimensional NMR experiments and DFT simulations.
Pia Burboa-Schettino, Carlos Bustos, Elies Molins, Xavier F. Figueroa, Jesus Llanquinao, Ximena Zarate, Gabriel Vallejos, Carlos Diaz-Uribe, William Vallejo, Eduardo Schott   +9 more
doaj  

Microwave-Assisted Synthesis of some Novel Azoles and Azolopyrimidines as Antimicrobial Agents

Molecules, 2017
In this study, new derivatives of pyrazole, isoxazole, pyrazolylthiazole, and azolopyrimidine having a thiophene ring were synthesized under microwave irradiation.
Sobhi M. Gomha, Thoraya A. Farghaly, Yahia Nasser Mabkhot, Mohie E. M. Zayed, Amany M. G. Mohamed   +4 more
doaj   +1 more source

Thermally Activated Delayed Fluorescence and Beyond. Photophysics and Material Design Strategies.

Advanced Photonics Research, EarlyView.
Photophysical properties of TADF molecules are determined by characteristic parameters that are discussed in detail(. Moreover, using femtosecond time‐resolved spectroscopy, quantum mechanical considerations, and state‐of‐art calculations, deeper understanding allows us to design breakthrough Cu(I) and organic TADF‐ OLED materials. For the latter ones,
Hartmut Yersin, Uwe Monkowius
wiley   +1 more source

Styrylpyrazoles: Properties, Synthesis and Transformations

Molecules, 2020
The pyrazole nucleus and its reduced forms, pyrazolines and pyrazolidine, are privileged scaffolds in medicinal chemistry due to their remarkable biological activities. A huge number of pyrazole derivatives have been studied and reported over time.
Pedro M. O. Gomes, Pedro M. S. Ouro, Artur M. S. Silva, Vera L. M. Silva   +3 more
doaj   +1 more source

Catalyst‐Free Direct Hydrocarbonation of Terminal Alkynes Toward E‐Alkene Substituted Stabilized Sulfoxonium Ylides

Advanced Science, EarlyView.
The authors introduce a high‐throughput synthesis using amide‐sulfoxonium ylides as new nucleophilic reagents, enabling a catalyst‐ and base‐free hydrocarbonation of terminal alkynes under mild conditions, resulting in various E‐alkene substituted (hetero)amide‐sulfoxonium ylides with excellent regio‐ and stereoselectivity. The late‐stage modifications
Haiting Wu, Yougen Xu, An Lin, Jingyuan Liu, Huanjun Chen, Shimin Xie, Lebin Su   +6 more
wiley   +1 more source

Design and synthesis of pyrazole derivatives for in vitro screening to protect angiotensin-converting enzyme 2 human cells against COVID-19

Current Medicine Research and Practice, 2021
Background: ACE2 is a receptor for Corona virus. COVID-19 (coronavirus) is a deadly virus which can enter the human body through 'angiotensin-converting enzyme 2' human cells, hardly damages the respiratory system. On severe infection on these cells make
Ganesh N Yallappa, S Rajendra Prasad, Gayatri Vaidya   +2 more
doaj   +1 more source

Synthesis of Five‐Membered Heterocycle Fused Quinazolinone Via Buchwald–Hartwig Cross Coupling Reaction

Asian Journal of Organic Chemistry, EarlyView.
Efficient Buchwald‐Hartwig cross‐coupling reactions were utilized to synthesize quinazolinone derivatives with a five‐membered heterocyclic ring substituted onto the quinazolinone structure, through reactions with various 2‐amino pyridine derivatives. This synthetic method is applicable to a total of six different five‐membered heterocyclic compounds ...
Jimin Moon, Hyojin Lee, Taeho Lee
wiley   +1 more source