Results 1 to 10 of about 212,860 (340)
Highly enantioselective catalytic synthesis of chiral pyridines
Nature Communications, 2017 Chiral pyridines are valuable building blocks in medicinal chemistry applications. Here, the authors report the copper-catalysed Lewis acid-assisted asymmetric alkylation of β-substituted alkenyl pyridines with Grignard reagents affording chiral ...
Ravindra P. Jumde +3 more
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1H-Pyrazolo[3,4-b]pyridines: Synthesis and Biomedical Applications
Molecules, 2022 Pyrazolo[3,4-b]pyridines are a group of heterocyclic compounds presenting two possible tautomeric forms: the 1H- and 2H-isomers. More than 300,000 1H-pyrazolo[3,4-b]pyridines have been described which are included in more than 5500 references (2400 ...
Ana Donaire-Arias +5 more
semanticscholar +1 more source
N-(Pyridin-2-ylmethyl)pyridin-2-amine [PDF]
Acta Crystallographica Section E Structure Reports Online, 2011 The title compound, C(11)H(11)N(3), crystallizes with two mol-ecules (A and B) in the asymmetric unit. The geometries of both mol-ecules are very similar, with the exception of the torsion angles of the inter-ring chains; the values for C-N-C-C are 67.4 (5) and -69.3 (5)° for mol-ecules A and B, respectively.
Suk-Hee Moon, Tae Ho Kim, Ki-Min Park
openaire +3 more sources
Halogenation of the 3-position of pyridines through Zincke imine intermediates
Science, 2022 Pyridine halogenation reactions are crucial for obtaining the vast array of derivatives required for drug and agrochemical development. However, despite more than a century of synthetic endeavors, halogenation processes that selectively functionalize the
Benjamin T. Boyle +4 more
semanticscholar +1 more source
Scientific Reports, 2022 In this study, we reported the ammonium metavanadate (NH4VO3) as an efficient, cost-effective, and mild catalyst for the synthesis of substituted pyridines via a one-pot pseudo four-component reaction.
Jamal Rahimi +6 more
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Practical and Regioselective Synthesis of C-4-Alkylated Pyridines.
Journal of the American Chemical Society, 2021 The direct position-selective C-4 alkylation of pyridines has been a long-standing challenge in heterocyclic chemistry, particularly from pyridine itself.
J. Choi +3 more
semanticscholar +1 more source
Communications Chemistry, 2023 Substituted pyridines with diverse functional groups are important structural motifs found in numerous bioactive molecules. Several methodologies for the introduction of various bio-relevant functional groups to pyridine have been reported, but there is ...
Kannan Vaithegi +4 more
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Visible light-promoted synthesis of 2-aryl-(3-organoselanyl)thieno[2,3-b]pyridines
Green Chemistry Letters and Reviews, 2022 We describe a simple and environment-friendly visible light-promoted protocol to access 2-aryl-(3-organoselanyl)thieno[2,3-b]pyridines, through the selenocyclization of 3-(arylethynyl)-2-(alkylthio)pyridines in the presence of diorganyl diselenides as ...
Ricardo Hellwig Bartz +5 more
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Sublimation/vaporization and solvation enthalpies of monosubstituted pyridine derivatives
Chemical Thermodynamics and Thermal Analysis, 2022 Different sectors, including medicine and display technology, utilize substituted pyridines. To establish the quality of products manufactured from pyridines, chemical thermodynamics of the solvation and evaporation enthalpies of the pyridines are ...
Rawand S. Abdullah, Boris N. Solomonov
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Regioselective C–H Activation of Substituted Pyridines and other Azines using Mg- and Zn-TMP-Bases
SynOpen, 2018 The metalation of substituted pyridines, diazines and related N-heterocycles using TMPMgCl·LiCl, TMP2Mg·2LiCl, TMPZnCl·LiCl or TMP2Zn·2LiCl2·2MgCl2 (TMP = 2,2,6,6-tetramethylpiperidyl) in the presence or absence of a Lewis acid is reviewed ...
Moritz Balkenhohl, Paul Knochel
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