Results 51 to 60 of about 16,008 (266)
Designing Enzymatic Reactivity with an Expanded Palette
ChemBioChem, EarlyView.Innovation in biocatalysis is rapidly increasingly the diversity of catalytic reactivity that can be mediated by enzymes, addressing a key bottleneck for their widespread adoption in industrial chemical synthesis. A key approach to this is building enzymes with unnatural catalytic components that provide an expanded palette with new possibilities for ...
Reuben B. Leveson‐Gower
wiley +1 more source
Is Mycobacterial InhA a Suitable Target for Rational Drug Design?
ChemMedChem, Accepted Article.InhA, an NAD‐dependent enoyl‐acyl carrier protein reductase, is involved in the biosynthesis of mycolic acids, specific lipids to mycobacteria. InhA is the target of isoniazid, a first‐line anti‐tuberculosis drug used since the 1950s. Isoniazid is a prodrug that needs to be activated by the catalase‐peroxidase KatG.
Julien Rizet +7 more
wiley +1 more source
ChemMedChem, Accepted Article.Kallikrein‐related peptidases are a family of serine proteases which loss of activity regulation has been particularly linked to neurodegenerative diseases. Moreover, iron overload is also a key process in some of these leading pathological conditions, particularly Alzheimer’s disease.
Rilès Boumali +11 more
wiley +1 more source
Recent advances in chemistry and pharmacological aspects of 2-pyridone scaffolds
Journal of Saudi Chemical Society, 2021 Background: The chemistry and applications of 2-pyridone structures have recently attracted a lot of attention due to their uses as synthetic intermediates and their biological importance.
Mostafa M.K. Amer +4 more
doaj
Synthesis of azo pyridone dyes [PDF]
Hemijska industrija, 2011 Over 50% of all colorants which are used nowdays are azo dyes and pigments, and among them arylazo pyridone dyes (and pigments) have became of interest in last several decades due to the high molar extinction coefficient, and the medium to high light and wet fastness properties. They find application generally as disperse dyes.
Dusan Mijin +3 more
openaire +3 more sources
Catalytic Dehydrogenation of Lauric Acid and a Potential Use in Polyester Synthesis
European Journal of Lipid Science and Technology, EarlyView.A three‐step reaction sequence was developed to synthesize renewable lauric acid–based dimethyl esters. The sequence consists of a catalytic dehydrogenation of saturated fatty acids with molecular oxygen as oxidant, an esterification with methanol, and a dimerization reaction with dithiols via thia‐Michael addition.
Luis Santos Correa +3 more
wiley +1 more source
A Straightforward Synthesis of Functionalized cis-Perhydroisoquinolin-1-ones
Molecules, 2019 Base-catalyzed annulation reactions of 5,6-dihydro-2(1H)-pyridones with Nazarov-type reagents are reported. The effect of the solvent polarity and the concentration of the reagents is studied.
Federica Arioli +5 more
doaj +1 more source
ChemistryOpen, EarlyView.Unprotected glycosyl pyridinium salts may be accessed in a single step from the corresponding unprotected sugar in aqueous solution. Whilst meta‐ and para‐substitution is well tolerated, ortho substitution of the N‐heterocycle inhibits product formation. Electrochemical studies revealed reduction potentials in the range of −0.9 to −1.4 V.
Daniel Chong +2 more
wiley +1 more source
ChemistryOpen, 2020 1,2,4‐Oxadiazole[4,5‐a]piridinium salts add alcohols and alkoxides to undergo electrocyclic ring opening affording alkoxybutadienyl 1,2,4‐oxadiazole derivatives.
Dr. Mattia Moiola +2 more
doaj +1 more source
Phenacylation of 6-Methyl-Beta-Nitropyridin-2-Ones and Further Heterocyclization of Products
Molecules, 2020 Reaction between the derivatives of 6-methyl-beta-nitropyridin-2-one and phenacyl bromides was studied, and the yields observed were extremely low. The pyridones were converted via chloropyridines to methoxyderivatives, which were N-phenacylated.
Eugene V. Babaev, Victor B. Rybakov
doaj +1 more source