Results 81 to 90 of about 20,827 (302)

A Short Synthesis of (±)-3-Demethoxyerythratidinone by Ligand Controlled Selective Heck Cyclization of Equilibrating Enamines [PDF]

, 2017
A short, 5-step total synthesis of (±)-3-demethoxyerythratidinone from a simple pyrrole derivative is described. Features include the formation of gram quantities of a key tricylic aziridine from a challenging photochemical cascade reaction through the ...
Albini, Bach, Belleau, Blackham, Cassayre, Chikaoka, Chuang, Dean, Elliott, Gao, Gauthier, Heller, Ishibashi, Joo, Kirschbaum, Knowles, Kärkäs, Larionov, Le Anh Tuan, Lee, Luu, Martin, Maskill, Nicolaou, Onozaki, Padwa, Paladino, Parsons, Rigby, Rigby, Tolman, Trost, Tsuda, Tsuda, Wang, Wasserman, Xu, Zeni, Zhang, Zhang   +39 more
core   +2 more sources

Tautomerism of 4-Pyridones [PDF]

Bulletin of the Chemical Society of Japan, 1977
Abstract The tautomeric constants, Kt, of several 4-pyridones were determined by measurement of pKa values. For 2-substituted 5-methoxy-4-pyridones, the Kt values were correlated to the substituent constants σ, the equation logkt=2.98+2.93σm−6.18σo being obtained.
Hiromichi Besso, Kimiaki Imafuku, Hisashi Matsumura   +2 more
openaire   +1 more source

Access to N-Substituted 2-Pyridones by Catalytic Intermolecular Dearomatization and 1,4-Acyl Transfer.

Angewandte Chemie, 2018
A novel rhodium-catalyzed dearomatization of O-substituted pyridines to access N-substituted 2-pyridones has been developed. A computational study suggests a mechanism involving the formation of a pyridinium ylide followed by an unprecedented 1,4-acyl ...
Guangyang Xu, Ping-Fan Chen, Pei-Kang Liu, S. Tang, Xinhao Zhang, Jiangtao Sun   +5 more
semanticscholar   +1 more source

Synthesis and antimalarial potential of some novel quinoline-pyrazolopyridine derivatives [PDF]

, 2016
oai:eldorado.tu-dortmund.de:2003/35825A series of 1-(4-methylquinolin-2-yl)-4,6-diaryl-1H-pyrazolo[3,4-b]pyridin-3-amine derivatives was synthesized by the reaction of 3-cinnamoyl-4-hydroxy-6-methyl-2H-pyran-2-ones with 2-chloro-4,6 ...
Jain, Neelam, Jain, Sandeep, Kumar, Ajay, Saini, Deepika   +3 more
core   +1 more source

Integrative Evidence From Metabolome‐Wide Mendelian Randomization and Animal Models Implicates Tyrosine in Cardiac Hypercontractility and Arrhythmia Risk

Food Frontiers, Volume 7, Issue 1, January 2026.
Plasma metabolome‐wide Mendelian randomization analysis established a causal link between tyrosine and arrhythmia. GWAS meta‐analysis identified tyrosine‐associated loci linked to cardiovascular risk factors. Animal studies confirmed that oral tyrosine intake modulates heart rhythm via adrenergic signaling activation.
Zhikang Cao, Huiying Liu, Peng Chen, Liyue Chen, Zhixin Chen, Jiaqiang Lin, Zixuan Fu, Zhipeng Li   +7 more
wiley   +1 more source

Synthesis of New Aza-Heterocyclic Based on 2-Pyridone

Chemistry Proceedings
In this work, we present new methods of synthesis of different molecules including a 2-pyridone nucleus. First, we prepared a series of 1H-free 2-pyridones and N-alkyl 2-pyridones from ethyl cyanoacetate, aromatic aldehydes, various acetophenone ...
Ikram Baba-Ahmed, Zahira Kibou, Julio A. Seijas, Noureddine Choukchou-Braham, M. Pilar Vázquez-Tato   +4 more
doaj   +1 more source

Regioselective reactions of 3,4-pyridynes enabled by the aryne distortion model. [PDF]

, 2013
The pyridine heterocycle continues to play a vital role in the development of human medicines. More than 100 currently marketed drugs contain this privileged unit, which remains highly sought after synthetically. We report an efficient means to access di-
Garg, Neil K, Goetz, Adam E
core  

SAM-dependent enzyme-catalysed pericyclic reactions in natural product biosynthesis. [PDF]

, 2017
Pericyclic reactions-which proceed in a concerted fashion through a cyclic transition state-are among the most powerful synthetic transformations used to make multiple regioselective and stereoselective carbon-carbon bonds.
Chen, Mengbin, Hai, Yang, Houk, KN, Liu, Fang, Ohashi, Masao, Sato, Michio, Tang, Man-Cheng, Tang, Yi, Watanabe, Kenji, Yang, Zhongyue   +9 more
core   +1 more source

Metabolic Profiling of the EmDia Cohort by LC‐MS Reveals Empagliflozin‐Intake Associated Regulation of 1,5‐anhydroglucitol and Urate

PROTEOMICS, Volume 26, Issue 1, Page 44-56, January 2026.
ABSTRACT The EmDia trial, designed to study the effects of the sodium glucose cotransporter‐2 (SGLT2) inhibitor empagliflozin on cardiovascular comorbidities in type 2 diabetes mellitus (T2DM) patients, has been investigated for short‐term metabolic alterations by a limited set of clinical assays. To expand on this data, we report on the development of
Fabian Schmitt, Vincent ten Cate, Zlatka Fischer, Mathias Hagen, Barbara A. Steigenberger, Stefan Tenzer, Philipp S. Wild, Thierry Schmidlin   +7 more
wiley   +1 more source

A Straightforward Synthesis of Functionalized cis-Perhydroisoquinolin-1-ones

Molecules, 2019
Base-catalyzed annulation reactions of 5,6-dihydro-2(1H)-pyridones with Nazarov-type reagents are reported. The effect of the solvent polarity and the concentration of the reagents is studied.
Federica Arioli, Maria Pérez, Celeste Are, Elies Molins, Joan Bosch, Mercedes Amat   +5 more
doaj   +1 more source