Results 111 to 120 of about 319,341 (367)
GOT1 Inhibition Induces Extracellular Matrix Remodeling in Pancreatic Cancer
Advanced Science, EarlyView.Using tumor tissue engineering, we recreated pancreatic cancer and found that inhibiting glutamic‐oxaloacetic transaminase 1 (GOT1) induces extracellular matrix remodeling and secretome rewiring, as well as promotes cell death. ABSTRACT Pancreatic cancer cells rely on glutamine to sustain their survival in the stiff and poorly vascularized tumor ...
Rodrigo Curvello +10 more
wiley +1 more source
Novel One-Pot Synthesis of Pyrazolopyranopyrimidinones Using Newly Produced γ-Alumina Nanoparticles as Powerful Catalyst [PDF]
Iranian Journal of Chemistry & Chemical Engineering, 2018 g-Alumina nanoparticles (g-Al2O3 NPs) were prepared via a new and simple synthetic route and characterized by field emission scanning electron microscopy, X-ray diffraction, and Fourier transform infrared spectroscopy.
Sajad Kiani +4 more
doaj
Acta Crystallographica Section E: Crystallographic Communications, 2019 In 1-(2-iodobenzoyl)-4-(pyrimidin-2-yl)piperazine, C15H15IN4O, the central piperazine ring adopts an almost perfect chair conformation with the pyrimidine substituent in an equatorial site.
Ninganayaka Mahesha +4 more
doaj +1 more source
Functional and genetic evidence that nucleoside transport is highly conserved in Leishmania species: Implications for pyrimidine-based chemotherapy [PDF]
, 2017 Leishmania pyrimidine salvage is replete with opportunities for therapeutic intervention with enzyme inhibitors or antimetabolites. Their uptake into cells depends upon specific transporters; therefore it is essential to establish whether various ...
Ali, Juma A.M. +7 more
core +2 more sources
Abiotic synthesis of purine and pyrimidine ribonucleosides in aqueous microdroplets
Proceedings of the National Academy of Sciences of the United States of America, 2017 Significance Discovery of an improved prebiotic method for the synthesis of ribonucleosides provides support to theories that posit a central role for RNA in the origin of life. It has been assumed that ribonucleosides arose through an abiotic process in
Inho Nam, H. Nam, R. Zare
semanticscholar +1 more source
Advanced Science, EarlyView.Solution‐processible pure green multi‐resonance thermally activated delayed fluorescence (MR‐TADF) emitters are developed through a strategic acceptor‐bridging engineering approach that integrates MR‐building blocks with pyrimidine‐derived frameworks.
Xuming Zhuang +8 more
wiley +1 more source
, 2018 Orotic acid is an intermediate found in the pathway for pyrimidine synthesis. The mitochondrial enzyme dihydroorotate dehydrogenase (DHODH) catalyzes the production of orotic acid by the conversion of the compound dihydroorotate to orotic acid.
Fonteh, Aliah L
core +1 more source
Low-energy electron scattering by pyrazine [PDF]
, 2007 We report cross sections for low-energy elastic electron collisions with the diazabenzene molecule pyrazine, obtained from first-principles calculations.
McKoy, Vincent, Winstead, Carl
core +1 more source
Untersuchungen zum Ursprung der Substratspezifität von Enzymen der Amidohydrolase‐Superfamilie
Angewandte Chemie, EarlyView.Umfassende Analysen zweier Enzymklassen aus der Amidohydrolase‐Superfamilie (AHS) ergaben, dass die Katalyse über eine 1,4‐ bzw. 1,6‐nukleophile konjugierte Addition abläuft und diese Eigenschaft die Substratspezifität bestimmt. Obwohl alle Substrate und Produkte vollständig achiral sind, führt dieser mechanistische Unterschied zu einer invertierten ...
Lukas Drexler +3 more
wiley +1 more source
Three Dimensional Quantitative Structure-Activity Relationships of Sulfonamides Binding Monoclonal Antibody by Comparative Molecular Field Analysis [PDF]
, 2008 The three-dimensional quantitative structure-activity relationship (3D-QSAR) model of sulfonamide analogs binding a monoclonal antibody (MabSMR) produced against sulfamerazine, was carried out by comparative molecular field analysis (CoMFA).
Congming Wu +8 more
core +1 more source